{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:30:40Z","timestamp":1773721840206,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-105-2320-B-039-054"],"award-info":[{"award-number":["MOST-105-2320-B-039-054"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-107-2320-B-006-067"],"award-info":[{"award-number":["MOST-107-2320-B-006-067"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX105-10420BI"],"award-info":[{"award-number":["NHRI-EX105-10420BI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX106-10420BI"],"award-info":[{"award-number":["NHRI-EX106-10420BI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bbrc.2020.05.084","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T08:44:00Z","timestamp":1593074640000},"page":"487-493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages"],"prefix":"10.1016","volume":"530","author":[{"given":"Jen-Pin","family":"Chuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Yu","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenq-Chang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chei","family":"Maa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-6578","authenticated-orcid":false,"given":"Tzeng-Horng","family":"Leu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.05.084_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/ard.2004.024091","article-title":"Gout epidemiology: results from the UK general practice Research database, 1990-1999","volume":"64","author":"Mikuls","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2020.05.084_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.maturitas.2014.05.001","article-title":"Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities","volume":"78","author":"Robinson","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.bbrc.2020.05.084_bib3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.immuni.2008.09.013","article-title":"Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells","volume":"29","author":"Ng","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2020.05.084_bib4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/08820139.2016.1153651","article-title":"Cytokine profile in gout: inflammation driven by IL-6 and IL-18?","volume":"45","author":"Cavalcanti","year":"2016","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.bbrc.2020.05.084_bib5","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.4049\/jimmunol.138.10.3213","article-title":"Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1","volume":"138","author":"Di Giovine","year":"1987","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2020.05.084_bib6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular identification of a danger signal that alerts the immune system to dying cells","volume":"425","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.084_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.084_bib8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.molmed.2017.06.005","article-title":"Molecular pathophysiology of gout","volume":"23","author":"Desai","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2020.05.084_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1373520","article-title":"Molecular cloning of the interleukin-1 beta converting enzyme","volume":"256","author":"Cerretti","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.05.084_bib10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A\u00a0novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.084_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(00)81334-3","article-title":"Human ICE\/CED-3 protease nomenclature","volume":"87","author":"Alnemri","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2020.05.084_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2020.05.084_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.20172222","article-title":"Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity","volume":"215","author":"Boucher","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.05.084_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1182\/blood.V91.2.577","article-title":"Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells","volume":"91","author":"Schumann","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2020.05.084_bib15","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1038\/s41467-019-09753-2","article-title":"Caspase-1 initiates apoptosis in the absence of gasdermin D","volume":"10","author":"Tsuchiya","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2020.05.084_bib16","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/j.1460-2075.1993.tb06058.x","article-title":"Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals","volume":"12","author":"Fazioli","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2020.05.084_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0167-4889(99)00069-5","article-title":"Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src","volume":"1450","author":"Maa","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2020.05.084_bib18","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1074\/jbc.M309884200","article-title":"Participation of p97Eps8 in Src-mediated transformation","volume":"279","author":"Leu","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.05.084_bib19","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1038\/onc.2010.144","article-title":"The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation","volume":"29","author":"Liu","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2020.05.084_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/45822","article-title":"EPS8 and E3B1 transduce signals from Ras to Rac","volume":"401","author":"Scita","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.084_bib21","doi-asserted-by":"crossref","first-page":"19399","DOI":"10.1074\/jbc.M610280200","article-title":"Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase","volume":"282","author":"Maa","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.05.084_bib22","doi-asserted-by":"crossref","first-page":"18806","DOI":"10.1074\/jbc.M112.340935","article-title":"Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages","volume":"287","author":"Chen","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.05.084_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.0105-2896.2009.00851.x","article-title":"Monosodium urate crystals in inflammation and immunity","volume":"233","author":"Shi","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2020.05.084_bib24","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1002\/art.21238","article-title":"Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation","volume":"52","author":"Liu-Bryan","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2020.05.084_bib25","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/1529-0131(200008)43:8<1779::AID-ANR14>3.0.CO;2-2","article-title":"Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages. Implications for the control of joint inflammation in gout","volume":"43","author":"Yagnik","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2020.05.084_bib26","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.4049\/jimmunol.180.11.7147","article-title":"P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage","volume":"180","author":"Pelegrin","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2020.05.084_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1006\/bbrc.1998.9464","article-title":"Vanadate-dependent FAK activation is accomplished by the sustained FAK Tyr-576\/577 phosphorylation","volume":"251","author":"Maa","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.05.084_bib28","doi-asserted-by":"crossref","first-page":"34533","DOI":"10.1038\/srep34533","article-title":"Monosodium urate crystal-induced pro-interleukin-1beta production is post-transcriptionally regulated via the p38 signaling pathway in human monocytes","volume":"6","author":"Chung","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.05.084_bib29","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1084\/jem.20050640","article-title":"Blocking IL-1 in systemic inflammation","volume":"201","author":"Dinarello","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.05.084_bib30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.20050473","article-title":"Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade","volume":"201","author":"Pascual","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.05.084_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2020.05.084_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2020.05.084_bib33","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/jcs.114.6.1061","article-title":"Phagocytosis and the actin cytoskeleton","volume":"114","author":"May","year":"2001","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2020.05.084_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrm2818","article-title":"Emerging role for the cytoskeleton as an organizer and regulator of translation","volume":"11","author":"Kim","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20310032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20310032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:54:16Z","timestamp":1757764456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20310032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0006291X20310032"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.084","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}