{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:27:14Z","timestamp":1777562834050,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230009"],"award-info":[{"award-number":["81230009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871097"],"award-info":[{"award-number":["81871097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200491"],"award-info":[{"award-number":["81200491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571371"],"award-info":[{"award-number":["81571371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730066"],"award-info":[{"award-number":["81730066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20151554"],"award-info":[{"award-number":["BK20151554"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bbrc.2020.06.140","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T16:50:22Z","timestamp":1596473422000},"page":"1165-1172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bmi-1 determines the stemness of renal stem or progenitor cells"],"prefix":"10.1016","volume":"529","author":[{"given":"Jiawen","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2019ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-1695","authenticated-orcid":false,"given":"Haiyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-0007","authenticated-orcid":false,"given":"Hengzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengshun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-3210","authenticated-orcid":false,"given":"Jianliang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.06.140_bib1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2016.11.105","article-title":"Bmi-1 plays a critical role in the protection from acute tubular necrosis by mobilizing renal stem\/progenitor cells","volume":"482","author":"Lv","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.06.140_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2183\/pjab.93.001","article-title":"Low-protein diet for the prevention of renal failure","volume":"93","author":"Watanabe","year":"2017","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.bbrc.2020.06.140_bib3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/acel.12236","article-title":"Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance","volume":"13","author":"Jin","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2020.06.140_bib4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1385\/COMP:31:4:262","article-title":"Clinical acute renal failure: diagnosis and management","volume":"31","author":"Mitra","year":"2005","journal-title":"Compr. Ther."},{"key":"10.1016\/j.bbrc.2020.06.140_bib5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0002-9440(10)62276-6","article-title":"Isolation of renal progenitor cells from adult human kidney","volume":"166","author":"Bussolati","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2020.06.140_bib6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ki.2008.327","article-title":"Stem cells for kidney repair: useful tool for acute renal failure?","volume":"74","author":"Yokoo","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2020.06.140_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.kint.2017.02.036","article-title":"Molecular mechanisms of renal aging","volume":"92","author":"Schmitt","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2020.06.140_bib8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1172\/JCI20921","article-title":"The renal papilla is a niche for adult kidney stem cells","volume":"114","author":"Oliver","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2020.06.140_bib9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s12276-019-0371-7","article-title":"TGF-beta1\/IL-11\/MEK\/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency","volume":"52","author":"Chen","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2020.06.140_bib10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature08040","article-title":"Bmi1 regulates mitochondrial function and the DNA damage response pathway","volume":"459","author":"Liu","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.06.140_bib11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1359\/jbmr.090812","article-title":"Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice","volume":"25","author":"Zhang","year":"2010","journal-title":"J.\u00a0Bone Miner. Res. : Off. J. Am. Soc. Bone Min. Res."},{"key":"10.1016\/j.bbrc.2020.06.140_bib12","doi-asserted-by":"crossref","first-page":"13975","DOI":"10.1038\/srep13975","article-title":"Anti-aging effect of transplanted amniotic membrane mesenchymal stem cells in a premature aging model of bmi-1 deficiency","volume":"5","author":"Xie","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.06.140_bib13","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1210\/endo.142.2.7976","article-title":"Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition","volume":"142","author":"Miao","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2020.06.140_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/bmt.2008.260","article-title":"Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration","volume":"43","author":"Zhang","year":"2009","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.bbrc.2020.06.140_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"116","author":"Mullen","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2020.06.140_bib16","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1681\/ASN.2006010089","article-title":"Isolation and characterization of multipotent progenitor cells from the Bowman\u2019s capsule of adult human kidneys","volume":"17","author":"Sagrinati","year":"2006","journal-title":"J.\u00a0Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.bbrc.2020.06.140_bib17","article-title":"Bmi-1 absence causes premature brain degeneration","volume":"7","author":"Cao","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.06.140_bib18","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1172\/JCI23015","article-title":"Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney","volume":"115","author":"Lin","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2020.06.140_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24676","article-title":"IL-11 is a crucial determinant of cardiovascular fibrosis","volume":"552","author":"Schafer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.06.140_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/157488809787169129","article-title":"Contribution of stem cells to kidney repair","volume":"4","author":"Bussolati","year":"2009","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2020.06.140_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.gendis.2015.04.001","article-title":"Bmi-1: at the crossroads of physiological and pathological biology","volume":"2","author":"Bhattacharya","year":"2015","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbrc.2020.06.140_bib22","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1634\/stemcells.2007-0322","article-title":"Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes","volume":"26","author":"Metsuyanim","year":"2008","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2020.06.140_bib23","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1038\/s41598-017-06868-8","article-title":"P16 (INK4a) deletion ameliorated renal tubulointerstitial injury in a stress-induced premature senescence model of bmi-1 deficiency","volume":"7","author":"Jin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.06.140_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.06.140_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/sdi.12745","article-title":"Oxidative stress in hemodialysis: causative mechanisms, clinical implications, and possible therapeutic interventions","volume":"32","author":"Liakopoulos","year":"2019","journal-title":"Semin. Dial."},{"key":"10.1016\/j.bbrc.2020.06.140_bib26","doi-asserted-by":"crossref","first-page":"9109473","DOI":"10.1155\/2019\/9109473","article-title":"Antioxidant supplementation in renal replacement therapy patients: is there evidence?","volume":"2019","author":"Liakopoulos","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.bbrc.2020.06.140_bib27","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/ndt\/gfp659","article-title":"N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins","volume":"25","author":"Kim","year":"2010","journal-title":"Nephrol. Dial. Transplant. : Off. Publ.Eur. Dialysis Transplant Assoc. Eur. Renal Assoc."},{"key":"10.1016\/j.bbrc.2020.06.140_bib28","first-page":"3850","article-title":"P16(INK4a) played a critical role in exacerbating acute tubular necrosis in acute kidney injury","volume":"11","author":"Gu","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbrc.2020.06.140_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.jid.5700949","article-title":"Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis","volume":"128","author":"Lee","year":"2008","journal-title":"J.\u00a0Invest. Dermatol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20313589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20313589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:37:37Z","timestamp":1777401457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20313589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0006291X20313589"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.06.140","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bmi-1 determines the stemness of renal stem or progenitor cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.06.140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}