{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:15:42Z","timestamp":1778346942635,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbrc.2020.07.046","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T01:29:43Z","timestamp":1597454983000},"page":"490-496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chloride intracellular channel 4 is dysregulated in endometrium of women with infertility and alters receptivity"],"prefix":"10.1016","volume":"531","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-0049","authenticated-orcid":false,"given":"Cheuk Kwan","family":"Ling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2323","authenticated-orcid":false,"given":"Leilani L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-7963","authenticated-orcid":false,"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4324-4772","authenticated-orcid":false,"given":"Evdokia","family":"Dimitriadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.07.046_bib1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/humupd\/dml004","article-title":"Endometrial receptivity markers, the journey to successful embryo implantation","volume":"12","author":"Achache","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.bbrc.2020.07.046_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/14789450.2018.1464915","article-title":"Does the dysregulation of matrix metalloproteinases contribute to recurrent implantation failure?","volume":"15","author":"Benkhalifa","year":"2018","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.bbrc.2020.07.046_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12967-016-1052-0","article-title":"Integrins beta1 and beta3 are biomarkers of uterine condition for embryo transfer","volume":"14","author":"Chen","year":"2016","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.bbrc.2020.07.046_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/genes11040376","article-title":"Mother and embryo cross-communication","volume":"11","author":"Idelevich","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.bbrc.2020.07.046_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/rep.1.01076","article-title":"TGF-beta superfamily expression and actions in the endometrium and placenta","volume":"132","author":"Jones","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.bbrc.2020.07.046_bib6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2353\/ajpath.2009.080625","article-title":"Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway","volume":"174","author":"Ulmasov","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib7","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1242\/jcs.189795","article-title":"Emerging biological roles of Cl- intracellular channel proteins","volume":"129","author":"Argenzio","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2020.07.046_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fphys.2020.00096","article-title":"Intracellular chloride channels: novel biomarkers in diseases","volume":"11","author":"Gururaja Rao","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ncb1885","article-title":"TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3","volume":"11","author":"Shukla","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molmet.2015.01.003","article-title":"Clic4, a novel protein that sensitizes beta-cells to apoptosis","volume":"4","author":"Patel","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bbrc.2020.07.046_bib11","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/carcin\/bgs115","article-title":"CLIC4 is a tumor suppressor for cutaneous squamous cell cancer","volume":"33","author":"Suh","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2020.07.046_bib12","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/onc.2013.18","article-title":"CLIC4 regulates TGF-beta-dependent myofibroblast differentiation to produce a cancer stroma","volume":"33","author":"Shukla","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2020.07.046_bib13","first-page":"5189","article-title":"CLIC4 regulates cell adhesion and beta1 integrin trafficking","volume":"127","author":"Argenzio","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2020.07.046_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12958-020-00624-w","article-title":"Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity","volume":"18","author":"Zhou","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/molehr\/8.7.636","article-title":"Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells","volume":"8","author":"Dimitriadis","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bbrc.2020.07.046_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1095\/biolreprod.109.077800","article-title":"Models for study of human embryo implantation: choice of cell lines?","volume":"82","author":"Hannan","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbrc.2020.07.046_bib17","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.febslet.2010.03.013","article-title":"Two decades with dimorphic chloride intracellular channels (CLICs)","volume":"584","author":"Singh","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2020.07.046_bib18","first-page":"541","article-title":"CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer","volume":"22","author":"Yao","year":"2009","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2020.07.046_bib19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib20","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.241117","article-title":"CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division","volume":"133","author":"Peterman","year":"2020","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2020.07.046_bib21","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1071\/RD14240","article-title":"Actin crosslinking protein filamin A during early pregnancy in the rat uterus","volume":"28","author":"Madawala","year":"2016","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.bbrc.2020.07.046_bib22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jri.2015.02.002","article-title":"The role of apoptosis in human embryo implantation","volume":"108","author":"Boeddeker","year":"2015","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2020.07.046_bib24","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.febslet.2010.05.061","article-title":"Mcl-1; the molecular regulation of protein function","volume":"584","author":"Thomas","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2020.07.046_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0140-6736(94)91051-0","article-title":"Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle","volume":"344","author":"Otsuki","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2020.07.046_bib26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/19336918.2017.1393591","article-title":"Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion","volume":"12","author":"Young","year":"2018","journal-title":"Cell Adhes. Migrat."},{"key":"10.1016\/j.bbrc.2020.07.046_bib27","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1242\/jcs.138214","article-title":"STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition","volume":"127","author":"Renjini","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2020.07.046_bib28","doi-asserted-by":"crossref","first-page":"9231057","DOI":"10.1155\/2016\/9231057","article-title":"Functions of the tumor suppressors p53 and Rb in actin cytoskeleton remodeling","volume":"2016","author":"Ebata","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2020.07.046_bib29","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1158\/0008-5472.CAN-11-4199","article-title":"Integrin alpha5beta1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma","volume":"72","author":"Janouskova","year":"2012","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2020.07.046_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11010-011-0882-6","article-title":"Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin","volume":"357","author":"Qiu","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2020.07.046_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/bdrc.21122","article-title":"Molecular mechanisms of membrane interaction at implantation","volume":"108","author":"Davidson","year":"2016","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.bbrc.2020.07.046_bib32","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbrc.2012.06.160","article-title":"Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression","volume":"424","author":"Shirane","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.07.046_bib33","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1038\/s41598-017-04577-w","article-title":"KRAS activation and over-expression of SIRT1\/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance","volume":"7","author":"Yoo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.07.046_bib34","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/nm.2498","article-title":"Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure","volume":"17","author":"Salker","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2020.07.046_bib35","doi-asserted-by":"crossref","first-page":"17705","DOI":"10.1038\/s41598-018-35792-8","article-title":"CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion","volume":"8","author":"Papoff","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.07.046_bib36","doi-asserted-by":"crossref","first-page":"41573","DOI":"10.1074\/jbc.R300026200","article-title":"Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane","volume":"278","author":"Donaldson","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.07.046_bib37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/jb\/mvg181","article-title":"Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion","volume":"134","author":"Sabe","year":"2003","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.bbrc.2020.07.046_bib38","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1210\/en.2016-1629","article-title":"BMP7 induces uterine receptivity and blastocyst attachment","volume":"158","author":"Monsivais","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2020.07.046_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/molehr\/gaz011","article-title":"Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in\u00a0vitro model","volume":"25","author":"Berneau","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bbrc.2020.07.046_bib40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.theriogenology.2020.02.002","article-title":"Matrix metalloproteinases improves trophoblast invasion and pregnancy potential in mice","volume":"151","author":"Zhang","year":"2020","journal-title":"Theriogenology"},{"key":"10.1016\/j.bbrc.2020.07.046_bib41","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1071\/RD18314","article-title":"Role of epithelial-mesenchymal transition regulated by twist basic helix-loop-helix transcription factor 2 (Twist2) in embryo implantation in mice","volume":"31","author":"Gou","year":"2019","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.bbrc.2020.07.046_bib42","first-page":"247","article-title":"Cell adhesion molecules in human embryo implantation","volume":"64","author":"Fukuda","year":"2012","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.bbrc.2020.07.046_bib43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1055\/s-0034-1376356","article-title":"Autoimmune activation toward embryo implantation is rare in immune-privileged human endometrium","volume":"32","author":"Haller-Kikkatalo","year":"2014","journal-title":"Semin. Reprod. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20314364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20314364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:55:27Z","timestamp":1757764527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20314364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0006291X20314364"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.07.046","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chloride intracellular channel 4 is dysregulated in endometrium of women with infertility and alters receptivity","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.07.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}