{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:56:30Z","timestamp":1782950190889,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["GINOP-2.3.4-15-2016-00004"],"award-info":[{"award-number":["GINOP-2.3.4-15-2016-00004"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Magyarorsz\u00e1g Korm\u00e1nya","doi-asserted-by":"publisher","award":["EFOP-3.6.1-16-2016-00011"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00011"]}],"id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Magyarorsz\u00e1g Korm\u00e1nya","doi-asserted-by":"publisher","award":["GINOP-2.2.1-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.2.1-15-2016-00005"]}],"id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Magyarorsz\u00e1g Korm\u00e1nya","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00058"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00058"]}],"id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbrc.2020.07.086","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T02:52:19Z","timestamp":1597891939000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A \u201cketo-enol\u201d plaque buster mechanism to diminish Alzheimer\u2019s \u03b2-Amyloid burden"],"prefix":"10.1016","volume":"532","author":[{"given":"Ol\u00e1h","family":"Zolt\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pecze","family":"L\u00e1szl\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kocsis","family":"\u00c9va","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viskolcz","family":"B\u00e9la","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.07.086_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17020206","article-title":"Genetic and transcriptomic profiles of inflammation in neurodegenerative diseases: alzheimer, Parkinson, creutzfeldt-jakob and tauopathies","volume":"17","author":"Lopez Gonzalez","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib2","first-page":"53","article-title":"Cyclic amplification of protein misfolding and aggregation","volume":"299","author":"Saa","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","article-title":"A\u00a0critical appraisal of amyloid-beta-targeting therapies for Alzheimer disease","volume":"15","author":"Panza","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41582-018-0107-7","article-title":"Dementia with Lewy bodies - from scientific knowledge to clinical insights","volume":"15","author":"Arnaoutoglou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib5","doi-asserted-by":"crossref","first-page":"17342","DOI":"10.1073\/pnas.0506723102","article-title":"3D structure of Alzheimer\u2019s amyloid-beta(1-42) fibrils","volume":"102","author":"Luhrs","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2020.07.086_bib6","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1097\/MPA.0b013e3181788e18","article-title":"Higher islet amyloid load in men than in women with type 2 diabetes mellitus","volume":"37","author":"Zhao","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2020.07.086_bib7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nrd4749","article-title":"The Alzheimer disease market","volume":"14","author":"Qian","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2020.07.086_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2710.2003.00463.x","article-title":"Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer\u2019s disease: a double blind, randomized and placebo-controlled trial","volume":"28","author":"Akhondzadeh","year":"2003","journal-title":"J.\u00a0Clin. Pharm. Therapeut."},{"key":"10.1016\/j.bbrc.2020.07.086_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrd4593","article-title":"Targeting protein aggregation for the treatment of degenerative diseases","volume":"14","author":"Eisele","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2020.07.086_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1001\/archneur.62.5.779","article-title":"Alzheimer disease and mortality: a 15-year epidemiological study","volume":"62","author":"Ganguli","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1567205053585882","article-title":"A\u00a0potential role of the curry spice curcumin in Alzheimer\u2019s disease","volume":"2","author":"Ringman","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbrc.2020.07.086_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1124\/jpet.108.137455","article-title":"Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer\u2019s disease","volume":"326","author":"Begum","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.bbrc.2020.07.086_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-0-387-46401-5_8","article-title":"Neuroprotective effects of curcumin","volume":"595","author":"Cole","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral curcumin for Alzheimer\u2019s disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.bbrc.2020.07.086_bib15","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in\u00a0vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1212\/WNL.57.6.985","article-title":"Incidence of Alzheimer\u2019s disease in a rural community in India: the Indo-US study","volume":"57","author":"Chandra","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2020.07.086_bib17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1212\/WNL.51.4.1000","article-title":"Prevalence of Alzheimer\u2019s disease and other dementias in rural India: the Indo-US study","volume":"51","author":"Chandra","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2020.07.086_bib18","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1586\/14737175.2015.1044981","article-title":"Clinical development of curcumin in neurodegenerative disease","volume":"15","author":"Hu","year":"2015","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbrc.2020.07.086_bib20","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1074\/jbc.M112.393751","article-title":"Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice","volume":"288","author":"Ma","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib21","doi-asserted-by":"crossref","first-page":"28472","DOI":"10.1074\/jbc.M110.133520","article-title":"Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein","volume":"285","author":"Zhang","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib22","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.L110.133520","article-title":"Curcumin and Alzheimer disease: this marriage is not to be performed","volume":"286","author":"Mancuso","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease","volume":"28","author":"Baum","year":"2008","journal-title":"J.\u00a0Clin. Psychopharmacol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib24","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00170","article-title":"Evaluation of phytosomal curcumin as an anti-inflammatory agent for chronic glial activation in the GFAP-IL6 mouse model","volume":"14","author":"Ullah","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12868-018-0406-3","article-title":"Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"19","author":"Maiti","year":"2018","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201700005","article-title":"Mannich curcuminoids as potent anticancer agents","volume":"350","author":"Gyuris","year":"2017","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.bbrc.2020.07.086_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102105","article-title":"Achiral mannich-base curcumin analogs induce unfolded protein response and mitochondrial membrane depolarization in PANC-1 cells","volume":"18","author":"Szebeni","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149832","article-title":"The curcumin analog C-150, influencing NF-kappaB, UPR and akt\/notch pathways has potent anticancer activity in\u00a0vitro and in\u00a0vivo","volume":"11","author":"Hackler","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.07.086_bib30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1471-4159.2007.04613.x","article-title":"Curcumin labels amyloid pathology in\u00a0vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model","volume":"102","author":"Garcia-Alloza","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib31","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2174\/138161206777698792","article-title":"Inhibition of protein misfolding and aggregation by small rationally-designed peptides","volume":"12","author":"Estrada","year":"2006","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.bbrc.2020.07.086_bib32","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib33","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/protein\/4.8.903","article-title":"Electrostatic effects in proteins: comparison of dielectric and charge models","volume":"4","author":"Mehler","year":"1991","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.bbrc.2020.07.086_bib34","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib35","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1021\/jp2108736","article-title":"Interaction lowers hydrogen transfer barrier to keto-enol tautomerization of beta-cyclohexanedione: combined infrared spectroscopic and electronic structure calculation study","volume":"116","author":"Bandyopadhyay","year":"2012","journal-title":"J.\u00a0Phys. Chem."},{"key":"10.1016\/j.bbrc.2020.07.086_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0166-1280(00)00353-5","article-title":"Correlation of antifungal activity of selected \u00e1-substituted acetophenones with their keto\u2013enol tautomerization energy","volume":"504","author":"Rodr\u0131guez","year":"2000","journal-title":"J.\u00a0Mol. Struct.: THEOCHEM"},{"key":"10.1016\/j.bbrc.2020.07.086_bib37","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/carcin\/20.5.911","article-title":"Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes","volume":"20","author":"Dinkova-Kostova","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2020.07.086_bib38","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd.2018.109","article-title":"Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing","volume":"17","author":"Boland","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2020.07.086_bib39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.07.086_bib40","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.3390\/molecules18055389","article-title":"Curcumin and its carbocyclic analogs: structure-activity in relation to antioxidant and selected biological properties","volume":"18","author":"Bhullar","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2020.07.086_bib41","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1158\/1535-7163.MCT-11-0243","article-title":"Combining curcumin (diferuloylmethane) and heat shock protein inhibition for neurofibromatosis 2 treatment: analysis of response and resistance pathways","volume":"10","author":"Angelo","year":"2011","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.bbrc.2020.07.086_bib42","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.3892\/mmr.2015.3983","article-title":"Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90","volume":"12","author":"Lv","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2020.07.086_bib43","first-page":"388","article-title":"Effect of curcumin on the modulation of alphaA- and alphaB-crystallin and heat shock protein 70 in selenium-induced cataractogenesis in Wistar rat pups","volume":"17","author":"Manikandan","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbrc.2020.07.086_bib44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1615\/JEnvironPatholToxicolOncol.2014010913","article-title":"Curcumin augments the efficacy of antitumor drugs used in leukemia by modulation of heat shock proteins via HDAC6","volume":"33","author":"Sarkar","year":"2014","journal-title":"J.\u00a0Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2014.04.016","article-title":"Protective effect of curcumin against heavy metals-induced liver damage","volume":"69","author":"Garcia-Nino","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2020.07.086_bib46","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1196\/annals.1332.005","article-title":"NSAID and antioxidant prevention of Alzheimer\u2019s disease: lessons from in\u00a0vitro and animal models","volume":"1035","author":"Cole","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib47","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrd3505","article-title":"The amyloid cascade hypothesis for Alzheimer\u2019s disease: an appraisal for the development of therapeutics","volume":"10","author":"Karran","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2020.07.086_bib48","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1021\/cn500081s","article-title":"Discovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a neuroprotectant for Alzheimer\u2019s disease by hybridization of curcumin and melatonin","volume":"5","author":"Chojnacki","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib49","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1021\/acschemneuro.5b00082","article-title":"Curcumin\/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP\/PS1 mouse model","volume":"6","author":"Gerenu","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbrc.2020.07.086_bib50","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2210-11-4","article-title":"Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in\u00a0vivo","volume":"11","author":"Kudo","year":"2011","journal-title":"BMC Pharmacol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20314753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20314753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:34:18Z","timestamp":1776458058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20314753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0006291X20314753"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.07.086","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A \u201cketo-enol\u201d plaque buster mechanism to diminish Alzheimer\u2019s \u03b2-Amyloid burden","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.07.086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}