{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:12:16Z","timestamp":1760425936474,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bbrc.2020.09.073","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:51:48Z","timestamp":1601081508000},"page":"764-769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells"],"prefix":"10.1016","volume":"533","author":[{"given":"Debora","family":"Gentile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-1838","authenticated-orcid":false,"given":"Laura","family":"Berliocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-6523","authenticated-orcid":false,"given":"Rossella","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-6218","authenticated-orcid":false,"given":"Giacinto","family":"Bagetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-0697","authenticated-orcid":false,"given":"Maria Tiziana","family":"Corasaniti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.09.073_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/jn\/129.3.775S","article-title":"Prevention and therapy of cancer by dietary monoterpenes","volume":"129","author":"Crowell","year":"1999","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.bbrc.2020.09.073_bib2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/sj.bjp.0707237","article-title":"Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in\u00a0vitro","volume":"151","author":"Corasaniti","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.09.073_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.phrs.2006.11.010","article-title":"The essential oil of bergamot enhances the levels of amino acid neurotransmitters in the hippocampus of rat: implication of monoterpene hydrocarbons","volume":"55","author":"Morrone","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2020.09.073_bib4","doi-asserted-by":"crossref","first-page":"106766","DOI":"10.1016\/j.intimp.2020.106766","article-title":"Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: evidence for IL-1\u03b2, TNF-\u03b1, GAP, NGF and ERK involvement","volume":"86","author":"Ara\u00fajo-Filho","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2020.09.073_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1248\/bpb.b19-00495","article-title":"Neuroprotective effects of limonene (+) against A\u03b242-induced neurotoxicity in a Drosophila model of Alzheimer\u2019s disease","volume":"43","author":"Shin","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2020.09.073_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1158\/1940-6207.CAPR-12-0452","article-title":"Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer","volume":"6","author":"Miller","year":"2013","journal-title":"Canc. Prev. Res."},{"key":"10.1016\/j.bbrc.2020.09.073_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0113682","article-title":"Role of d-limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells","volume":"9","author":"Russo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2020.09.073_bib8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.phymed.2018.01.005","article-title":"Early LC3 lipidation induced by D-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells","volume":"40","author":"Berliocchi","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2020.09.073_bib9","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.2147\/OTT.S155716","article-title":"D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer","volume":"11","author":"Yu","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bbrc.2020.09.073_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2020.09.073_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2020.09.073_bib12","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.fct.2011.06.011","article-title":"The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients","volume":"49","author":"Adams","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2020.09.073_bib13","first-page":"111","article-title":"Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer, Cancer Chemother","volume":"42","author":"Vigushin","year":"1998","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbrc.2020.09.073_bib14","first-page":"25","volume":"vol. 125","author":"Kim","year":"2015"},{"key":"10.1016\/j.bbrc.2020.09.073_bib15","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1158\/1535-7163.MCT-18-1406","article-title":"Cell death induced by cationic amphiphilic drugs depends on lysosomal Ca2+ release and cyclic AMP","volume":"18","author":"Anand","year":"2019","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.bbrc.2020.09.073_bib16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","article-title":"The calpain system","volume":"83","author":"Goll","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2020.09.073_bib17","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.200601024","article-title":"Calpain is required for macroautophagy in mammalian cells","volume":"175","author":"Demarchi","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2020.09.073_bib18","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1038\/cddis.2011.29","article-title":"Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in\u00a0vivo","volume":"2","author":"Russo","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2020.09.073_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2006.12.009","article-title":"Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-\u03b2, and Bcl-2","volume":"25","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Mol. Cell."},{"key":"10.1016\/j.bbrc.2020.09.073_bib20","first-page":"914","article-title":"AMPK-independent induction of autophagy by cytosolic Ca2+ increase, Cell","volume":"22","author":"Grotemeier","year":"2010","journal-title":"Signals"},{"key":"10.1016\/j.bbrc.2020.09.073_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.fitote.2013.05.014","article-title":"Implication of limonene and linalyl acetate in cytotoxicity induced by bergamot essential oil in human neuroblastoma cells","volume":"89","author":"Russo","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bbrc.2020.09.073_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10456-012-9262-4","article-title":"Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation","volume":"15","author":"Il Kwak","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbrc.2020.09.073_bib23","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1073\/pnas.1818598116","article-title":"Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation","volume":"116","author":"Davis","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2020.09.073_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1365-2443.1999.00270.x","article-title":"Changes in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action","volume":"4","author":"Morishima","year":"1999","journal-title":"Gene Cell."},{"key":"10.1016\/j.bbrc.2020.09.073_bib25","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2020.09.073_bib26","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1091\/mbc.e04-03-0272","article-title":"The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeletonle","volume":"15","author":"Styers","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2020.09.073_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0209665","article-title":"The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy","volume":"14","author":"Biskou","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2020.09.073_bib28","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.yexcr.2007.03.040","article-title":"Novel functions of vimentin in cell adhesion, migration, and signaling","volume":"313","author":"Ivaska","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2020.09.073_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/cells7100147","article-title":"Vimentin diversity in health and disease","volume":"7","author":"Danielsson","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2020.09.073_bib30","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.autrev.2018.04.004","article-title":"Vimentin as antigenic target in autoimmunity: a comprehensive review","volume":"17","author":"Musaelyan","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bbrc.2020.09.073_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21134675","article-title":"Vimentin as a multifaceted player and potential therapeutic target in viral infections","volume":"21","author":"Ramos","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2020.09.073_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-016-0234-7","article-title":"Surface vimentin is critical for the cell entry of SARS-CoV","volume":"23","author":"Yu","year":"2016","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.bbrc.2020.09.073_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41584-020-0372-x","article-title":"Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology","volume":"16","author":"Schrezenmeier","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrc.2020.09.073_bib34","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc.2017.53","article-title":"Targeting autophagy in cancer","volume":"17","author":"Levy","year":"2017","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2020.09.073_bib35","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1126\/science.abb9332","article-title":"Rapid repurposing of drugs for COVID-19","volume":"368","author":"Kiplin Guy","year":"2020","journal-title":"Science (80-"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20318209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20318209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:06:51Z","timestamp":1757765211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20318209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0006291X20318209"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.09.073","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.09.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}