{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:46:45Z","timestamp":1788684405906,"version":"build-2803163510"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013227","name":"Hoshi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbrc.2020.11.030","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T22:46:57Z","timestamp":1605739617000},"page":"624-631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch"],"prefix":"10.1016","volume":"534","author":[{"given":"Takao","family":"Setsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yozo","family":"Ishiuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ochiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tezuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kuzumaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.11.030_bib1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.318.5848.188","article-title":"Grasping for clues to the biology of itch","volume":"318","author":"Miller","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.11.030_bib2","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMcp1208814","article-title":"Clinical practice. Chronic pruritus","volume":"368","author":"Yosipovitch","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2020.11.030_bib3","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/exd.14029","article-title":"Addiction and the itch-scratch cycle. What do they have in common?","volume":"28","author":"Ishiuji","year":"2019","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2020.11.030_bib4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1152\/jn.00374.2013","article-title":"The cerebral representation of scratching-induced pleasantness","volume":"111","author":"Mochizuki","year":"2014","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.bbrc.2020.11.030_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neulet.2017.08.046","article-title":"Itch induces conditioned place aversion in mice","volume":"658","author":"Mu","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2020.11.030_bib6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2020.11.030_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00011-017-1048-0","article-title":"Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling","volume":"66","author":"Sakai","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2020.11.030_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-2999(91)90774-K","article-title":"Pertussis toxin abolishes mu- and delta-opioid agonist-induced place preference","volume":"205","author":"Suzuki","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.11.030_bib9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","article-title":"Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine","volume":"26","author":"Narita","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2020.11.030_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918756406","article-title":"Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer","volume":"14","author":"Watanabe","year":"2018","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbrc.2020.11.030_bib11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2013.03.025","article-title":"Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations","volume":"78","author":"Guenthner","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2020.11.030_bib12","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/brain\/awz084","article-title":"Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson\u2019s disease","volume":"142","author":"Kuzumaki","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.bbrc.2020.11.030_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082389","article-title":"Brain\u2019s reward circuits mediate itch relief. a functional MRI study of active scratching","volume":"8","author":"Papoiu","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.11.030_bib14","doi-asserted-by":"crossref","first-page":"9856","DOI":"10.1523\/JNEUROSCI.1483-18.2018","article-title":"Dynamics and functional role of dopaminergic neurons in the ventral tegmental area during itch processing","volume":"38","author":"Yuan","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2020.11.030_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/bjd.16921","article-title":"Impact of acute stress on itch sensation and scratching behaviour in patients with atopic dermatitis and healthy controls","volume":"180","author":"Mochizuki","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bbrc.2020.11.030_bib16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/sj.npp.1301435","article-title":"Psychological stress can trigger atopic dermatitis in NC\/Nga mice: an inhibitory effect of corticotropin-releasing factor","volume":"33","author":"Amano","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbrc.2020.11.030_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41593-019-0342-2","article-title":"Rapid, biphasic CRF neuronal responses encode positive and negative valence","volume":"22","author":"Kim","year":"2019","journal-title":"Nat. Neurosci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20320672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20320672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:08:29Z","timestamp":1757765309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20320672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":17,"alternative-id":["S0006291X20320672"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.11.030","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}