{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:47:59Z","timestamp":1792597679642,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012566","name":"Health System Independent Innovation Science Foundation of Shanghai Putuo District","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbrc.2020.11.061","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T08:52:15Z","timestamp":1606467135000},"page":"450-456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes"],"prefix":"10.1016","volume":"534","author":[{"given":"Lina","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixuan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-8542","authenticated-orcid":false,"given":"Ji","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiebo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunman","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.11.061_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","article-title":"CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease","volume":"14","author":"Anders","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11892-016-0735-5","article-title":"Podocytes: the weakest link in diabetic kidney disease?","volume":"16","author":"Lin","year":"2016","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.bbrc.2020.11.061_bib3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jfma.2018.02.007","article-title":"Update of pathophysiology and management of diabetic kidney disease","volume":"117","author":"Lin","year":"2018","journal-title":"J.\u00a0Formos. Med. Assoc."},{"key":"10.1016\/j.bbrc.2020.11.061_bib4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","article-title":"A\u00a0glimpse of various pathogenetic mechanisms of diabetic nephropathy","volume":"6","author":"Kanwar","year":"2011","journal-title":"Annual Review of Pathology"},{"key":"10.1016\/j.bbrc.2020.11.061_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2017.12.040","article-title":"Diabetic nephropathy: is there a role for oxidative stress?","author":"Sagoo","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.11.061_bib6","first-page":"3797802","article-title":"Role of nuclear factor erythroid 2-related factor 2 in diabetic nephropathy","volume":"2017","author":"Cui","year":"2017","journal-title":"J\u00a0Diabetes Res"},{"key":"10.1016\/j.bbrc.2020.11.061_bib7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ki.2012.439","article-title":"Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease","volume":"83","author":"Ruiz","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2020.11.061_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000324694","article-title":"Attenuation of glomerular injury in diabetic mice with tert-butylhydroquinone through nuclear factor erythroid 2-related factor 2-dependent antioxidant gene activation","volume":"33","author":"Li","year":"2011","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib9","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.2337\/db11-0807","article-title":"Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy","volume":"60","author":"Zheng","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2020.11.061_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.11.061_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(98)00127-6","article-title":"Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein","volume":"424","author":"Shiraki-Iida","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2020.11.061_bib12","doi-asserted-by":"crossref","DOI":"10.1515\/BC.2008.028","article-title":"Klotho as a regulator of oxidative stress and senescence","volume":"389","author":"Kuro-o","year":"2008","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.11.061_bib13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbadis.2017.09.029","article-title":"Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-kappaB-mediated inflammation both in\u00a0vitro and in\u00a0vivo","volume":"1864","author":"Guo","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbrc.2020.11.061_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","article-title":"The Klotho proteins in health and disease","volume":"15","author":"Kuro","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/ckj\/sfz125","article-title":"Klotho, the elusive kidney-derived anti-ageing factor","volume":"13","author":"Sanchez-Nino","year":"2020","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.bbrc.2020.11.061_bib16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ki.2011.423","article-title":"Decreased renal alpha-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion","volume":"81","author":"Asai","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2020.11.061_bib17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s10157-015-1202-3","article-title":"Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice","volume":"20","author":"Kadoya","year":"2016","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13190","article-title":"Klotho protein supplementation reduces blood pressure and renal hypertrophy in db\/db mice, a model of type 2 diabetes","volume":"225","author":"Takenaka","year":"2019","journal-title":"Acta Physiol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib19","doi-asserted-by":"crossref","first-page":"F791","DOI":"10.1152\/ajprenal.00462.2017","article-title":"Klotho plays a protective role against glomerular hypertrophy in a cell cycle-dependent manner in diabetic nephropathy","volume":"315","author":"Oh","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib20","doi-asserted-by":"crossref","first-page":"110490","DOI":"10.1016\/j.mce.2019.110490","article-title":"Klotho inhibits PKCalpha\/p66SHC-mediated podocyte injury in diabetic nephropathy","volume":"494","author":"Jiang","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/jcmm.12996","article-title":"The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells","volume":"21","author":"Maltese","year":"2017","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2020.11.061_bib22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/excr.1997.3739","article-title":"Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines","volume":"236","author":"Mundel","year":"1997","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2020.11.061_bib23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphar.2016.00500","article-title":"Astragaloside IV attenuates podocyte apoptosis mediated by endoplasmic reticulum stress through upregulating sarco\/endoplasmic reticulum Ca(2+)-ATPase 2 expression in diabetic nephropathy","volume":"7","author":"Guo","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib24","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/HYPERTENSIONAHA.109.134320","article-title":"Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage","volume":"54","author":"Wang","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2020.11.061_bib25","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/ndt\/gfi165","article-title":"Klotho reduces apoptosis in experimental ischaemic acute renal failure","volume":"20","author":"Sugiura","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2020.11.061_bib26","first-page":"513853","article-title":"Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats","volume":"2010","author":"Cheng","year":"2010","journal-title":"J.\u00a0Biomed. Biotechnol."},{"key":"10.1016\/j.bbrc.2020.11.061_bib27","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/db10-1262","article-title":"Klotho depletion contributes to increased inflammation in kidney of the db\/db mouse model of diabetes via RelA (serine)536 phosphorylation","volume":"60","author":"Zhao","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2020.11.061_bib28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/15384101.2019.1580495","article-title":"Klotho attenuates diabetic nephropathy in db\/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells","volume":"18","author":"Wang","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbrc.2020.11.061_bib29","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1055\/s-0044-101601","article-title":"Klotho restraining egr1\/TLR4\/mTOR Axis to reducing the expression of fibrosis and inflammatory cytokines in high glucose cultured rat mesangial cells","volume":"127","author":"Wu","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bbrc.2020.11.061_bib30","first-page":"7504798","article-title":"Research progress on the pathological mechanisms of podocytes in diabetic nephropathy","volume":"2020","author":"Zhang","year":"2020","journal-title":"J\u00a0Diabetes Res"},{"key":"10.1016\/j.bbrc.2020.11.061_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.365","article-title":"Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K\/AKT pathway during tacrolimus-induced oxidative stress","volume":"8","author":"Lim","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2020.11.061_bib32","doi-asserted-by":"crossref","first-page":"24700","DOI":"10.1074\/jbc.M114.567321","article-title":"The neuroprotective effect of Klotho is mediated via regulation of members of the redox system","volume":"289","author":"Chen","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.11.061_bib33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.18632\/aging.100194","article-title":"The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging","volume":"2","author":"Hsieh","year":"2010","journal-title":"Aging"},{"key":"10.1016\/j.bbrc.2020.11.061_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1152\/japplphysiol.00792.2015","article-title":"alphaKlotho deficiency in acute kidney injury contributes to lung damage","volume":"120","author":"Ravikumar","year":"1985","journal-title":"J.\u00a0Appl. Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20321069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20321069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:02:23Z","timestamp":1757764943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20321069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":34,"alternative-id":["S0006291X20321069"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.11.061","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.11.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}