{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:19:51Z","timestamp":1774045191225,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19dm0107128h0004"],"award-info":[{"award-number":["19dm0107128h0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbrc.2020.12.036","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T15:05:43Z","timestamp":1608131143000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["A potential defense mechanism against amyloid deposition in cerebellum"],"prefix":"10.1016","volume":"535","author":[{"given":"Alam","family":"Shahnur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-6891","authenticated-orcid":false,"given":"Nobuto","family":"Kakuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuuna","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Moniruzzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-9251","authenticated-orcid":false,"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi C.","family":"Saido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8433-4846","authenticated-orcid":false,"given":"Satoru","family":"Funamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.12.036_bib1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer\u2019s disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2020.12.036_bib2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/357500a0","article-title":"Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments","volume":"357","author":"Haass","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.12.036_bib3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0896-6273(95)90323-2","article-title":"Generation of amyloid beta protein from its precursor is sequence specific","volume":"14","author":"Citron","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2020.12.036_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.semcdb.2020.04.002","article-title":"Successive cleavage of \u03b2-amyloid precursor protein by \u03b3-secretase","volume":"105","author":"Funamoto","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2020.12.036_bib5","doi-asserted-by":"crossref","first-page":"1255555","DOI":"10.1126\/science.1255555","article-title":"Alzheimer\u2019s and Parkinson\u2019s diseases: the prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein","volume":"349","author":"Goedert","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.12.036_bib6","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1523\/JNEUROSCI.5825-09.2010","article-title":"A\u00a0mouse model of amyloid \u03b2 oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in\u00a0vivo","volume":"30","author":"Tomiyama","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2020.12.036_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neulet.2011.07.045","article-title":"Profiles of SUMO and ubiquitin conjugation in an Alzheimer\u2019s disease model","volume":"502","author":"McMillan","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2020.12.036_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"N.\u00a0Mihira et\u00a0all., Single App knock-in mouse models of Alzheimer\u2019s disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2020.12.036_bib9","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.ajpath.2020.02.009","article-title":"\u03b3-Secretase activity is associated with braak senile plaque stages","volume":"190","author":"Kakuda","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2020.12.036_bib10","doi-asserted-by":"crossref","first-page":"14776","DOI":"10.1074\/jbc.M513453200","article-title":"Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase","volume":"281","author":"Kakuda","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.12.036_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuroscience.2011.04.035","article-title":"Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse","volume":"186","author":"Takeda","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2020.12.036_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fnagi.2016.00160","article-title":"Mechanisms of A\u03b2 clearance and degradation by glial cells","volume":"8","author":"Ries","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2020.12.036_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ajpath.2010.11.012","article-title":"Neprilysin-2 is an important \u03b2-amyloid degrading enzyme","volume":"178","author":"Hafez","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2020.12.036_bib14","doi-asserted-by":"crossref","first-page":"6220","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.12.036_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.12.036_bib16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41586-019-1419-5","article-title":"Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid","volume":"572","author":"Ahn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.12.036_bib17","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.3389\/fimmu.2019.03043","article-title":"Lymph flow induces the postnatal formation of mature and functional meningeal lymphatic vessels","volume":"10","author":"Balint","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2020.12.036_bib18","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A\u00a0dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.12.036_bib19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.1983.sp014731","article-title":"Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit","volume":"339","author":"Bradbury","year":"1983","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2020.12.036_bib20","first-page":"88","article-title":"Determination of volumetric cerebrospinal fluid absorption into extracranial lymphatics in sheep","volume":"274","author":"Boulton","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2020.12.036_bib21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.1980.sp013129","article-title":"The role of the lymphatic system in drainage of cerebrospinal fluid and aqueous humour","volume":"299","author":"Bradbury","year":"1980","journal-title":"J.\u00a0Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20322130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20322130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:38:59Z","timestamp":1762094339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20322130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":21,"alternative-id":["S0006291X20322130"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.036","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A potential defense mechanism against amyloid deposition in cerebellum","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}