{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:16:40Z","timestamp":1788628600694,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016072","name":"Postdoctoral Scientific Research Development Fund of Heilongjiang Province","doi-asserted-by":"publisher","award":["LBH-Q18087"],"award-info":[{"award-number":["LBH-Q18087"]}],"id":[{"id":"10.13039\/100016072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbrc.2020.12.059","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T07:01:35Z","timestamp":1609138895000},"page":"7-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Exogenous hydrogen sulfide inhibits neutrophils extracellular traps formation via the HMGB1\/TLR4\/p-38 MAPK\/ROS axis in hyperhomocysteinemia rats"],"prefix":"10.1016","volume":"537","author":[{"given":"Xueying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.12.059_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12013-010-9079-y","article-title":"Homocysteine to hydrogen sulfide or hypertension","volume":"57","author":"Sen","year":"2010","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2020.12.059_bib2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nm0496-386","article-title":"Homocysteine and vascular disease","volume":"2","author":"McCully","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2020.12.059_bib3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.yexcr.2018.07.007","article-title":"Exogenous hydrogen sul\ufb01de protects from endothelial cell damage, platelet activation, and neutrophils extracellular traps formation in hyperhomocysteinemia rat","volume":"370","author":"Zhao","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2020.12.059_bib4","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1172\/JCI81660","article-title":"Platelet-derived HMGB1 is a critical mediator of thrombosis","volume":"125","author":"Vogel","year":"2015","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2020.12.059_bib5","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1111\/jth.12710","article-title":"Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps","volume":"12","author":"Maugeri","year":"2014","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.bbrc.2020.12.059_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2020.12.059_bib7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.yjmcc.2011.12.009","article-title":"Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress","volume":"52","author":"Wang","year":"2012","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib8","doi-asserted-by":"crossref","first-page":"9647809","DOI":"10.1155\/2018\/9647809","article-title":"Hydrogen sulfide alleviates lipopolysaccharide induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS\/MAPK and TLR4\/NF-\u03baB signaling pathways","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2020.12.059_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.12.059_bib10","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1161\/ATVBAHA.112.300627","article-title":"Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in\u00a0vitro and in\u00a0vivo","volume":"32","author":"Pircher","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2006.12.011","article-title":"Hydrogen sulfide inhibits human platelet aggregation","volume":"559","author":"Zagli","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/jth.13239","article-title":"Neutrophil elastase-de\ufb01cient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis","volume":"14","author":"Martinod","year":"2016","journal-title":"J.\u00a0Thromb. Haemostasis"},{"key":"10.1016\/j.bbrc.2020.12.059_bib13","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.1073\/pnas.1301059110","article-title":"Neutrophil histone modi\ufb01cation by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice","volume":"110","author":"Martinod","year":"2013","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2020.12.059_bib14","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/SHK.0b013e31816a6bb1","article-title":"Neutrophil-derived circulating free DNA (cF-DNA\/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis","volume":"30","author":"Margraf","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.bbrc.2020.12.059_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yexcr.2017.06.013","article-title":"Calcium sensing receptor initiating cystathionine-gamma-lyase\/hydrogen sul\ufb01de pathway to inhibit platelet activation in hyperhomocysteinemia rat","volume":"358","author":"Wang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2020.12.059_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.18388\/abp.2013_1983","article-title":"Neutrophil extracellular traps (nets) \u2013 formation and implications","volume":"60","author":"Zawrotniak","year":"2013","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cca.2015.03.027","article-title":"Gasomediators (\u00b7NO, CO, and H2S) and their role in hemostasis and thrombosis,","volume":"445","author":"Olas","year":"2015","journal-title":"Clin. Clim. Acta."},{"key":"10.1016\/j.bbrc.2020.12.059_bib18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.smim.2016.10.013","article-title":"Role of platelets in neutrophil extracellular trap (NET) production and tissue injury","volume":"28","author":"Kim","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib19","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1182\/blood-2016-04-710632","article-title":"Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice","volume":"128","author":"Stark","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2020.12.059_bib20","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1159\/000490818","article-title":"Emerging role of high mobility group box-1 in thrombosis-related diseases","volume":"47","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2020.12.059_bib21","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/s41598-018-20479-x","article-title":"Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA","volume":"8","author":"Dyer","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.12.059_bib22","doi-asserted-by":"crossref","first-page":"L342","DOI":"10.1152\/ajplung.00151.2012","article-title":"HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4","volume":"304","author":"Tadie","year":"2013","journal-title":"Physiol. Lung. Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-016-0447-7","article-title":"Indirubin inhibits LPS-induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways","volume":"40","author":"Lai","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2020.12.059_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.1101400","article-title":"Human PAD4 regulates histone arginine methylation levels via demethylimination","volume":"306","author":"Wang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.12.059_bib25","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.4049\/jimmunol.178.10.6573","article-title":"Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling","volume":"178","author":"Fan","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib26","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2020.12.059_bib27","doi-asserted-by":"crossref","first-page":"11952","DOI":"10.1038\/s41598-017-09731-y","article-title":"Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress","volume":"7","author":"Mohamed","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20322361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20322361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:38:54Z","timestamp":1762094334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20322361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":27,"alternative-id":["S0006291X20322361"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.059","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exogenous hydrogen sulfide inhibits neutrophils extracellular traps formation via the HMGB1\/TLR4\/p-38 MAPK\/ROS axis in hyperhomocysteinemia rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.12.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}