{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:53:59Z","timestamp":1758048839366,"version":"3.44.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bbrc.2021.01.009","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T01:46:00Z","timestamp":1611020760000},"page":"78-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Optimization of adenoviral gene transfer in human pluripotent stem cells"],"prefix":"10.1016","volume":"541","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-9845","authenticated-orcid":false,"given":"Kaoru","family":"Mitsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9529-7323","authenticated-orcid":false,"given":"Kanako","family":"Ide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichiro","family":"Kosai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.01.009_bib1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/mt.sj.6300125","article-title":"Human embryonic stem cells and gene therapy","volume":"15","author":"Strulovici","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2021.01.009_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.stem.2019.06.010","article-title":"Defining human pluripotency","volume":"25","author":"Yilmaz","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2021.01.009_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2021.01.009_bib4","series-title":"Interface Oral Health Science 2016","first-page":"121","article-title":"Gene delivery and expression systems in induced pluripotent stem cells","author":"Zhang","year":"2017"},{"key":"10.1016\/j.bbrc.2021.01.009_bib5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/stem.2725","article-title":"Novel construction of lentiviral vectors for eliminating tumorigenic cells from pluripotent stem cells","volume":"36","author":"Ide","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbrc.2021.01.009_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/hum.2013.2527","article-title":"Adenovirus: the first effective in\u00a0vivo gene delivery vector","volume":"25","author":"Crystal","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbrc.2021.01.009_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ymthe.2006.05.010","article-title":"Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting","volume":"14","author":"Takahashi","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2021.01.009_bib8","doi-asserted-by":"crossref","first-page":"15026","DOI":"10.1038\/mtm.2015.26","article-title":"Conditionally replicating adenovirus prevents pluripotent stem cell-derived teratoma by specifically eliminating undifferentiated cells","volume":"2","author":"Mitsui","year":"2015","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.bbrc.2021.01.009_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/jhep.2003.50018","article-title":"An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice","volume":"37","author":"Terazaki","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.01.009_bib10","first-page":"77","article-title":"Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma","volume":"27","author":"Yuge","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2021.01.009_bib11","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/sj.gt.3301453","article-title":"A\u00a0simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob","volume":"8","author":"Mizuguchi","year":"2001","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbrc.2021.01.009_bib12","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1093\/humrep\/17.9.2380","article-title":"Adenovirus gene transfer vector toxicity to mouse embryos: implications for human IVF","volume":"17","author":"Gordon","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.bbrc.2021.01.009_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/rmv.494","article-title":"Adenovirus: from foe to friend","volume":"16","author":"Goncalves","year":"2006","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.bbrc.2021.01.009_bib14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/scd.2015.0301","article-title":"High-efficient transfection of human embryonic stem cells by single-cell plating and starvation","volume":"25","author":"Liu","year":"2016","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.bbrc.2021.01.009_bib15","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1261\/rna.2350710","article-title":"High-efficiency siRNA-based gene knockdown in human embryonic stem cells","volume":"16","author":"Ma","year":"2010","journal-title":"RNA"},{"key":"10.1016\/j.bbrc.2021.01.009_bib16","doi-asserted-by":"crossref","first-page":"13781","DOI":"10.1073\/pnas.0806976105","article-title":"Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors","volume":"105","author":"Suzuki","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21000425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21000425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:59:17Z","timestamp":1757764757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21000425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":16,"alternative-id":["S0006291X21000425"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.01.009","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of adenoviral gene transfer in human pluripotent stem cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}