{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:45:24Z","timestamp":1790772324131,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.bbrc.2021.01.086","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T15:46:27Z","timestamp":1612626387000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1\/PGC-1\u03b1 pathway"],"prefix":"10.1016","volume":"546","author":[{"given":"Jiayu","family":"Diao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghua","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiling","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2021.01.086_bib1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cardfail.2014.02.007","article-title":"The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota","volume":"20","author":"Dandamudi","year":"2014","journal-title":"J.\u00a0Card. Fail."},{"issue":"24","key":"10.1016\/j.bbrc.2021.01.086_bib2","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1001\/jama.2017.7596","article-title":"Prevalence of ethnic pattern of diabetes and prediabetes in China in 2013","volume":"317","author":"Wang","year":"2017","journal-title":"J.\u00a0Am. Med. Assoc."},{"issue":"7","key":"10.1016\/j.bbrc.2021.01.086_bib3","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3390\/cells8070680","article-title":"Mitochondria\u2002in health and disease","volume":"8","author":"Annesley","year":"2019","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.bbrc.2021.01.086_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1253\/jcj.63.130","article-title":"Rapid progression of cardiomyopathy in mitochondrial diabetes","volume":"63","author":"Momiyama","year":"1999","journal-title":"Jpn. Circ. J."},{"issue":"7","key":"10.1016\/j.bbrc.2021.01.086_bib5","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/CIRCULATIONAHA.113.008476","article-title":"Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients","volume":"130","author":"Montaigne","year":"2014","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bbrc.2021.01.086_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13105-018-0648-7","article-title":"Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats","volume":"75","author":"Diao","year":"2019","journal-title":"J.\u00a0Physiol. Biochem."},{"issue":"9\u201310","key":"10.1016\/j.bbrc.2021.01.086_bib7","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1242\/dmm.001941","article-title":"Rodent models of diabetic cardiomyopathy","volume":"2","author":"Bugger","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbrc.2021.01.086_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of\u2002SIRT1\u2002in aging: roles in mitochondrial function and biogenesis","volume":"155","author":"Yuan","year":"2016","journal-title":"Mech. Ageing Dev."},{"issue":"9","key":"10.1016\/j.bbrc.2021.01.086_bib9","doi-asserted-by":"crossref","first-page":"e858","DOI":"10.3390\/antiox9090858","article-title":"SIRT1\/SIRT3 modulates redox homeostasis during ischemia\/reperfusion in the aging\u2002heart","volume":"9","author":"Zhang","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrc.2021.01.086_bib10","doi-asserted-by":"crossref","first-page":"101538","DOI":"10.1016\/j.redox.2020.101538","article-title":"SIRT1\u2002agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during\u2002ischemia\u2002and\u2002reperfusion","volume":"34","author":"Han","year":"2020","journal-title":"Redox. Biol."},{"issue":"21","key":"10.1016\/j.bbrc.2021.01.086_bib11","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1242\/jcs.113662","article-title":"PGC1\u03b1 and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders","volume":"125","author":"Austin","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2021.01.086_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14348\/molcells.2016.2318","article-title":"Sirt1 and the mitochondria","volume":"39","author":"Tang","year":"2016","journal-title":"Mol. Cell."},{"issue":"4","key":"10.1016\/j.bbrc.2021.01.086_bib13","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bmc.2010.01.019","article-title":"Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to\u2002mitochondria","volume":"18","author":"Roser","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2021.01.086_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12013-018-0857-2","article-title":"Superoxide formation in cardiac\u2002mitochondria\u2002and effect of Phenolic antioxidants","volume":"77","author":"Dudylina","year":"2019","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bbrc.2021.01.086_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/diseases4010014","article-title":"Effect of dietary bioactive compounds on mitochondrial and metabolic flexibility","volume":"4","author":"Serrano","year":"2016","journal-title":"Diseases"},{"issue":"8","key":"10.1016\/j.bbrc.2021.01.086_bib16","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3390\/nu11081886","article-title":"Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria","volume":"11","author":"Dilberger","year":"2019","journal-title":"Nutrients"},{"issue":"29","key":"10.1016\/j.bbrc.2021.01.086_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/0973-1296.93316","article-title":"Comparative study of rosmarinic acid content in some plants of Labiatae family","volume":"8","author":"Shekarchi","year":"2012","journal-title":"Phcog. Mag."},{"issue":"6","key":"10.1016\/j.bbrc.2021.01.086_bib18","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1142\/S0192415X15500640","article-title":"Rosmarinic Acid attenuates sodium taurocholate-induced acute pancreatitis in rats by inhibiting nuclear factor-\u03baB activation","volume":"43","author":"Fan","year":"2015","journal-title":"Am. J. Chin. Med."},{"issue":"1\u20132","key":"10.1016\/j.bbrc.2021.01.086_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.lfs.2014.07.010","article-title":"Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells","volume":"113","author":"Ghaffari","year":"2014","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.bbrc.2021.01.086_bib20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.bbrc.2016.07.024","article-title":"Rosmarinic Acid suppressed high glucose-induced apoptosis in H9c2 cells by ameliorating the mitochondrial function and activating STAT3","volume":"477","author":"Diao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.bbrc.2021.01.086_bib21","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/jcb.25869","article-title":"Rosmarinic acid mediates mitochondrial biogenesis in insulin resistant skeletal muscle through activation of AMPK","volume":"118","author":"Jayanthy","year":"2017","journal-title":"J.\u00a0Cell. Biochem."},{"issue":"6","key":"10.1016\/j.bbrc.2021.01.086_bib22","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1210\/endo.136.6.7750472","article-title":"Stimulation of glucose uptake and increased plasma membrane content of glucose transporters in L6 skeletal muscle cells by the sulfonylureas gliclazide and glyburide","volume":"136","author":"Tsiani","year":"1995","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bbrc.2021.01.086_bib23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1667\/RR14590.1","article-title":"Synthesis and characterization of a\u2002rosmarinic\u2002acid\u2002derivative that targets mitochondria and protects against radiation-induced damage in\u00a0vitro","volume":"188","author":"Zhang","year":"2017","journal-title":"Radiat. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2021.01.086_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pharmthera.2014.01.003","article-title":"Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways","volume":"142","author":"Huynh","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"25","key":"10.1016\/j.bbrc.2021.01.086_bib25","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1021\/acs.jafc.9b02045","article-title":"Lonicera caerulea berry polyphenols activate SIRT1, enhancing inhibition of raw264.7 macrophage foam cell formation and promoting cholesterol efflux","volume":"67","author":"Liu","year":"2019","journal-title":"Agric. Food. Chem."},{"issue":"5","key":"10.1016\/j.bbrc.2021.01.086_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","article-title":"SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function","volume":"15","author":"Price","year":"2012","journal-title":"Cell Metabol."},{"issue":"20","key":"10.1016\/j.bbrc.2021.01.086_bib27","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1111\/jcmm.15782","article-title":"Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis via\u2002SIRT1\/p53 signalling","volume":"24","author":"Zhang","year":"2020","journal-title":"J.\u00a0Cell Mol. Med."},{"issue":"10","key":"10.1016\/j.bbrc.2021.01.086_bib28","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s41419-020-03012-9","article-title":"SIRT1\u2002deacetylates\u2002mitochondrial\u2002trifunctional enzyme \u03b1 subunit to inhibit ubiquitylation and decrease insulin resistance","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.bbrc.2021.01.086_bib29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3390\/ijms20020452","article-title":"Isodon rugosus (Wall. ex Benth.) Codd in\u00a0vitro cultures: establishment, phytochemical characterization and in\u00a0vitro antioxidant and anti-aging activities","volume":"20","author":"Abbasi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bbrc.2021.01.086_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2007.03.006","article-title":"The\u2002GLUT4\u2002glucose transporter","volume":"5","author":"Huang","year":"2007","journal-title":"Cell. Metab"},{"issue":"5","key":"10.1016\/j.bbrc.2021.01.086_bib31","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1152\/ajpendo.00560.2009","article-title":"Abnormal in\u00a0vivo myocardial energy substrate uptake in diet-induced type 2\u2002diabetic\u2002cardiomyopathy\u2002in rats","volume":"298","author":"M\u00e9nard","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"16","key":"10.1016\/j.bbrc.2021.01.086_bib32","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jacc.2009.04.074","article-title":"Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging","volume":"54","author":"Rijzewijk","year":"2009","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.bbrc.2021.01.086_bib33","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/oby.2011.208","article-title":"Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans,","volume":"20","author":"Peterson","year":"2012","journal-title":"Obesity (Silver Spring)"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21001510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21001510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:00:53Z","timestamp":1757764853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21001510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":33,"alternative-id":["S0006291X21001510"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.01.086","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1\/PGC-1\u03b1 pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.01.086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}