{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:14:22Z","timestamp":1792466062091,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K22978"],"award-info":[{"award-number":["20K22978"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19127954"],"award-info":[{"award-number":["JP19127954"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bbrc.2021.03.049","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T17:02:21Z","timestamp":1616173341000},"page":"120-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1"],"prefix":"10.1016","volume":"552","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-5550","authenticated-orcid":false,"given":"Aya","family":"Nakae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-7572","authenticated-orcid":false,"given":"Michiko","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal G.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.03.049_bib1","series-title":"U.S. Cancer Statistics Data Visualizations Tool, Based on November 2018 Submission Data (1999\u20132016)","year":"2019"},{"key":"10.1016\/j.bbrc.2021.03.049_bib2","doi-asserted-by":"crossref","first-page":"e1066","DOI":"10.1200\/JOP.18.00793","article-title":"Optimizing the Care of malignant bowel obstruction in patients with advanced gynecologic cancer","volume":"15","author":"Lee","year":"2019","journal-title":"J\u00a0Oncol Pract"},{"key":"10.1016\/j.bbrc.2021.03.049_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrclinonc.2013.5","article-title":"Latest research and treatment of advanced-stage epithelial ovarian cancer","volume":"10","author":"Coleman","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1158\/1078-0432.CCR-13-2287","article-title":"Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas","volume":"20","author":"Pennington","year":"2014","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.bbrc.2021.03.049_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ygyno.2007.01.038","article-title":"What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?","volume":"105","author":"Han","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2021.03.049_bib7","doi-asserted-by":"crossref","first-page":"E7301","DOI":"10.1073\/pnas.1705441114","article-title":"In\u00a0vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer","volume":"114","author":"Kodama","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.049_bib8","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.cell.2015.02.038","article-title":"Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis","volume":"160","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.03.049_bib9","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1128\/JVI.02776-15","article-title":"Hepatocyte factor JMJD5 regulates hepatitis B virus replication through interaction with HBx","volume":"90","author":"Kouwaki","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib10","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1021\/acs.jproteome.5b00932","article-title":"Parallel accumulation-serial fragmentation (PASEF): multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device","volume":"14","author":"Meier","year":"2015","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.bbrc.2021.03.049_bib11","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1074\/mcp.TIR118.000900","article-title":"Online parallel accumulation-serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer","volume":"17","author":"Meier","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbrc.2021.03.049_bib12","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/pmic.200900437","article-title":"Scaffold: a bioinformatic tool for validating MS\/MS-based proteomic studies","volume":"10","author":"Searle","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.bbrc.2021.03.049_bib13","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1158\/0008-5472.CAN-05-3694","article-title":"Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas","volume":"66","author":"Hendrix","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2021.03.049_bib14","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1158\/1078-0432.CCR-08-0196","article-title":"Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome","volume":"14","author":"Tothill","year":"2008","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.bbrc.2021.03.049_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/path.2547","article-title":"A\u00a0prognostic gene expression index in ovarian cancer - validation across different independent data sets","volume":"218","author":"Denkert","year":"2009","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1476-5586(04)80047-2","article-title":"ONCOMINE: a cancer microarray database and integrated data-mining platform","volume":"6","author":"Rhodes","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbrc.2021.03.049_bib17","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ygyno.2020.01.006","article-title":"Predictive biomarkers of platinum and taxane resistance using the transcriptomic data of 1816 ovarian cancer patients","volume":"156","author":"Fekete","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib18","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s41467-019-09437-x","article-title":"USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7","volume":"10","author":"Sapmaz","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.03.049_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112352","article-title":"Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments","volume":"9","author":"Ha","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2021.03.049_bib20","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1073\/pnas.91.6.2156","article-title":"Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization","volume":"91","author":"Kallioniemi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.049_bib21","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.cell.2005.11.007","article-title":"A\u00a0genomic and functional inventory of deubiquitinating enzymes","volume":"123","author":"Nijman","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.03.049_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrd.2017.152","article-title":"Deubiquitylating enzymes and drug discovery: emerging opportunities","volume":"17","author":"Harrigan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2021.03.049_bib23","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1038\/onc.2011.443","article-title":"Deubiquitinases in cancer: new functions and therapeutic options","volume":"31","author":"Fraile","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2021.03.049_bib24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrc991","article-title":"Inhibiting the p53-MDM2 interaction: an important target for cancer therapy","volume":"3","author":"Ch\u00e8ne","year":"2003","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2021.03.049_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13045-017-0500-5","article-title":"MDM2\/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer","volume":"10","author":"Tisato","year":"2017","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib26","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1016\/j.celrep.2019.05.104","article-title":"Increased cholesterol biosynthesis is a key characteristic of breast cancer stem cells influencing patient outcome","volume":"27","author":"Ehmsen","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2021.03.049_bib27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc3151","article-title":"Targeting protein prenylation for cancer therapy","volume":"11","author":"Berndt","year":"2011","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2021.03.049_bib28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nri1839","article-title":"Statin therapy and autoimmune disease: from protein prenylation to immunomodulation","volume":"6","author":"Greenwood","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib29","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00262-016-1884-8","article-title":"The administration of drugs inhibiting cholesterol\/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice","volume":"65","author":"Lanterna","year":"2016","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbrc.2021.03.049_bib30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ygyno.2008.06.007","article-title":"Impact of statin therapy on survival in epithelial ovarian cancer","volume":"111","author":"Elmore","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib31","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ygyno.2014.04.007","article-title":"Effect of statin on risk of gynecologic cancers: a meta-analysis of observational studies and randomized controlled trials","volume":"133","author":"Liu","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2021.03.049_bib32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1001\/jama.2020.0150","article-title":"Association between genetically proxied inhibition of HMG-CoA reductase and epithelial ovarian cancer","volume":"323","author":"Yarmolinsky","year":"2020","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.bbrc.2021.03.049_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.clinbiochem.2007.03.016","article-title":"Mevalonate pathway: a review of clinical and therapeutical implications","volume":"40","author":"Buhaescu","year":"2007","journal-title":"Clin. Biochem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21004319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21004319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:04:02Z","timestamp":1757765042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21004319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":33,"alternative-id":["S0006291X21004319"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.049","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}