{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:55:54Z","timestamp":1768312554176,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"am","delay-in-days":334,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bbrc.2021.03.119","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:25:48Z","timestamp":1617150348000},"page":"7-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["PET imaging of 11C-labeled thiamine tetrahydrofurfuryl disulfide, vitamin B1 derivative: First-in-human study"],"prefix":"10.1016","volume":"555","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-5599","authenticated-orcid":false,"given":"Yasuyoshi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Mawatari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Aita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Nakaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Onoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Akamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-5841","authenticated-orcid":false,"given":"Hisashi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Senda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.03.119_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchromb.2004.11.004","article-title":"Determination of thiamine and its phosphate esters in rat tissues analyzed as thiochromes on a RP-amide C16 column","volume":"816","author":"Batifoulier","year":"2005","journal-title":"J.\u00a0Chromat. B-Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbrc.2021.03.119_bib2","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1471-4159.1975.tb03901.x","article-title":"Decreased metabolism in\u00a0vivo of glucose into amino acids of the brain of thiamine-deficient rats after treatment with pyrithiamine","volume":"24","author":"Gaitonde","year":"1975","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2021.03.119_bib3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1471-4159.1968.tb08961.x","article-title":"The effects of a thiamine antagonist, pyrithiamine, on levels of selected metabolic intermediates and on activities of thiamine-dependent enzymes in brain and liver","volume":"15","author":"Holowach","year":"1968","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2021.03.119_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/pgmj.73.855.27","article-title":"Wernicke-Korsakoff syndrome","volume":"73","author":"Zubaran","year":"1997","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.bbrc.2021.03.119_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1536\/ihj.46.751","article-title":"Histopathological changes of biopsied myocardium in Shoshin beriberi","volume":"46","author":"Kawano","year":"2005","journal-title":"Internatl. Heart J."},{"key":"10.1016\/j.bbrc.2021.03.119_bib6","first-page":"124","article-title":"Vitamin B1 nutritional status assessed by blood vitamin B1 values of middle-aged Japanese men and women","volume":"23","author":"Takeda","year":"2004","journal-title":"Trace Nutr. Res."},{"key":"10.1016\/j.bbrc.2021.03.119_bib7","doi-asserted-by":"crossref","first-page":"M16","DOI":"10.1093\/geronj\/46.1.M16","article-title":"Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency","volume":"46","author":"Smidt","year":"1991","journal-title":"J.\u00a0Gerontol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/07315724.1996.10718593","article-title":"Plasma and erythrocyte thiamin concentrations in geriatric outpatients","volume":"15","author":"Chen","year":"1996","journal-title":"J.\u00a0Am. Coll. Nutr."},{"key":"10.1016\/j.bbrc.2021.03.119_bib9","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/ajcn\/66.4.925","article-title":"The response to treatment of subclinical thiamine deficiency in the elderly","volume":"66","author":"Wilkinson","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2021.03.119_bib10","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1111\/j.1532-5415.2009.02542.x","article-title":"The role of low plasma thiamin levels in cognitively impaired elderly patients presenting with acute behavioral disturbances","volume":"57","author":"Vognar","year":"2009","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.bbrc.2021.03.119_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11011-008-9129-y","article-title":"Thiamine deficiency-related brain dysfunction in chronic liver failure","volume":"24","author":"Butterworth","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbrc.2021.03.119_bib12","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/archneur.55.9.1242","article-title":"Development of Wernicke-Korsakoff syndrome after long intervals following gastrectomy","volume":"55","author":"Shimomura","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib13","first-page":"114","article-title":"Thiamine and its fat-soluble derivatives as therapeutic agents","volume":"7","author":"Lonsdale","year":"1987","journal-title":"Int. Clin. Nutr. Rev."},{"key":"10.1016\/j.bbrc.2021.03.119_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00965632","article-title":"The turnover of thiamine and its phosphate esters in rat organs","volume":"1","author":"Sen","year":"1976","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2021.03.119_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.nutres.2009.10.007","article-title":"Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats","volume":"29","author":"Nozaki","year":"2009","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bbrc.2021.03.119_bib16","first-page":"227","article-title":"Beriberi cardiomyopathy","volume":"46","author":"Djoenaidi","year":"1992","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2021.03.119_bib17","doi-asserted-by":"crossref","first-page":"31925","DOI":"10.1074\/jbc.274.45.31925","article-title":"Cloning of the human thiamine transporter, a member of the folate transporter family","volume":"274","author":"Dutta","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.03.119_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0005-2736(02)00341-3","article-title":"Expression and promoter analysis of SLC19A2 in the human intestine","volume":"1561","author":"Reidling","year":"2002","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"10.1016\/j.bbrc.2021.03.119_bib19","first-page":"G491","article-title":"Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine","volume":"286","author":"Said","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib20","first-page":"G1127","article-title":"Adaptive regulation of intestinal thiamin uptake: molecular mechanism using wild-type and transgenic mice carrying hTHTR-1 and-2 promoters","volume":"288","author":"Reidling","year":"2005","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib21","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1021\/acs.joc.5b00685","article-title":"Synthesis of 11C-labeled Thiamine and fursultiamine for in\u00a0vivo molecular imaging of vitamin B1 and its prodrug using Positron Emission Tomography","volume":"80","author":"Doi","year":"2015","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.bbrc.2021.03.119_bib22","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s11307-018-1186-y","article-title":"PET imaging analysis of vitamin B1 kinetics with [11C]thiamine and its derivative [11C]thiamine tetrahydrofurfuryl disulfide in rats","volume":"20","author":"Nozaki","year":"2018","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib23","first-page":"RA199","article-title":"Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent (Review)","volume":"10","author":"Lonsdale","year":"2004","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.bbrc.2021.03.119_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013616","article-title":"Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells","volume":"5","author":"Gangolf","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2021.03.119_bib25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0197-0186(94)00123-C","article-title":"Thiamine homeostasis in neuroblastoma-cells","volume":"26","author":"Bettendorff","year":"1995","journal-title":"Neurochem. Neurochem. Int.."},{"key":"10.1016\/j.bbrc.2021.03.119_bib26","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2021.03.119_bib27","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.lfs.2004.04.016","article-title":"Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus","volume":"75","author":"Bajotto","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2021.03.119_bib28","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00125-004-1582-5","article-title":"High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats","volume":"47","author":"Babaei-Jadidi","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2021.03.119_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00592-008-0042-y","article-title":"Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications","volume":"45","author":"Beltramo","year":"2008","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2174\/157339905774574383","article-title":"The potential role of Thiamine (vitamin B1) in diabetic complications","volume":"1","author":"Thornalley","year":"2005","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.bbrc.2021.03.119_bib31","first-page":"144","article-title":"Clinical and experimental studies on the excessive administration of thiamine","volume":"33","author":"Fukutomi","year":"1966","journal-title":"Vitamines"},{"key":"10.1016\/j.bbrc.2021.03.119_bib32","first-page":"1396","article-title":"Klinische Erfahrungen mit einem neuen Thiamin-Derivat bei Rheumatischen Erkrankungen","volume":"59","author":"Yano","year":"1964","journal-title":"Med. Klin."},{"key":"10.1016\/j.bbrc.2021.03.119_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2967\/jnumed.110.081539","article-title":"PET imaging of the gastrointestinal absorption of orally administered drugs in conscious and anesthetized rats","volume":"52","author":"Yamashita","year":"2011","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.bbrc.2021.03.119_bib34","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1021\/mp300469m","article-title":"Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron Emission Tomography imaging after oral administration of nonabsorbable marker, [18F]Deoxyfluoropoly(ethylene glycol)","volume":"10","author":"Takashima","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.03.119_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/clpt.2011.267","article-title":"Imaging of gastrointestinal absorption and biodistribution of an orally administered probe using Positron Emission Tomography in humans","volume":"91","author":"Shingaki","year":"2012","journal-title":"Clin. Pharmacol. Ther."}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2021.04.039","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21005179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21005179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:03:33Z","timestamp":1757765013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21005179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":35,"alternative-id":["S0006291X21005179"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.119","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.bbrc.2021.04.039","asserted-by":"object"}]},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PET imaging of 11C-labeled thiamine tetrahydrofurfuryl disulfide, vitamin B1 derivative: First-in-human study","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.119","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}