{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:13:47Z","timestamp":1793308427024,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bbrc.2021.03.163","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T13:22:41Z","timestamp":1617888161000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Mechanosensitive Piezo1 channel activation promotes ventilator-induced lung injury via disruption of endothelial junctions in ARDS rats"],"prefix":"10.1016","volume":"556","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-0360","authenticated-orcid":false,"given":"Lulu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.03.163_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ccc.2018.03.004","article-title":"Determinants and prevention of ventilator-induced lung injury","volume":"34","author":"Vasques","year":"2018","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.bbrc.2021.03.163_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/atm.ATM_63_20","article-title":"Ventilator dyssynchrony - detection, pathophysiology, and clinical relevance: a Narrative review","volume":"15","author":"Sottile","year":"2020","journal-title":"Ann. Thorac. Med."},{"key":"10.1016\/j.bbrc.2021.03.163_bib3","first-page":"890","article-title":"[New advances in molecular mechanisms of ventilator induced lung injury]","volume":"32","author":"Jiang","year":"2020","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.bbrc.2021.03.163_bib4","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1056\/NEJMra1208707","article-title":"Ventilator-induced lung injury","volume":"369","author":"Slutsky","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2021.03.163_bib5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/physrev.00035.2003","article-title":"Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis","volume":"84","author":"Bazzoni","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2021.03.163_bib6","doi-asserted-by":"crossref","first-page":"L452","DOI":"10.1152\/ajplung.00231.2016","article-title":"Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets","volume":"312","author":"Wang","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.bbrc.2021.03.163_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1165\/rcmb.2018-0418ED","article-title":"Piezo1 in the lung: at last!","volume":"60","author":"Bhattacharya","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2021.03.163_bib8","doi-asserted-by":"crossref","first-page":"F303","DOI":"10.1152\/ajprenal.00214.2019","article-title":"Expression and distribution of PIEZO1 in the mouse urinary tract","volume":"317","author":"Dalghi","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2021.03.163_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/bs.ctm.2016.11.003","article-title":"Mechanosensitive Piezo channels in the gastrointestinal tract","volume":"79","author":"Alcaino","year":"2017","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.bbrc.2021.03.163_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuron.2019.01.050","article-title":"The mechanosensitive ion channel Piezo inhibits axon regeneration","volume":"102","author":"Song","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2021.03.163_bib11","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.tips.2019.10.002","article-title":"Piezo ion channels in cardiovascular mechanobiology","volume":"40","author":"Douguet","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2021.03.163_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature13701","article-title":"Piezo1 integration of vascular architecture with physiological force","volume":"515","author":"Li","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.03.163_bib13","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1084\/jem.20180483","article-title":"Piezo1 and Gq\/G11 promote endothelial inflammation depending on flow pattern and integrin activation","volume":"215","author":"Albarran-Juarez","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2021.03.163_bib14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"Acute Lung Injury in Animals Study, an official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2021.03.163_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/17476348.2018.1457954","article-title":"Ventilator-induced lung injury during controlled ventilation in patients with acute respiratory distress syndrome: less is probably better","volume":"12","author":"Cruz","year":"2018","journal-title":"Expet Rev. Respir. Med."},{"key":"10.1016\/j.bbrc.2021.03.163_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","article-title":"Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity","volume":"573","author":"Solis","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.03.163_bib17","doi-asserted-by":"crossref","first-page":"16876","DOI":"10.1038\/s41598-019-51518-w","article-title":"Piezo1 channel activation mimics high glucose as a stimulator of insulin release","volume":"9","author":"Deivasikamani","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2021.03.163_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","article-title":"Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.03.163_bib19","first-page":"2545","article-title":"Endothelial adherens junctions at a glance","volume":"126","author":"Dejana","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2021.03.163_bib20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/ATVBAHA.119.313545","article-title":"Interference with ESAM (endothelial cell-selective adhesion molecule) plus vascular endothelial-cadherin causes immediate lethality and lung-specific blood coagulation","volume":"40","author":"Duong","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2021.03.163_bib21","doi-asserted-by":"crossref","first-page":"12980","DOI":"10.1073\/pnas.1902165116","article-title":"Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions","volume":"116","author":"Friedrich","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.163_bib22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1091\/mbc.e16-06-0459","article-title":"p120-catenin regulates VE-cadherin endocytosis and degradation induced by the Kaposi sarcoma-associated ubiquitin ligase K5","volume":"28","author":"Nanes","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2021.03.163_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1091\/mbc.e16-09-0658","article-title":"The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis","volume":"28","author":"Su","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2021.03.163_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-4939-8988-1_12","article-title":"Identification of calpain-activated protein functions","volume":"1915","author":"Del Carmen Lafita-Navarro","year":"2019","journal-title":"Methods Mol. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21005763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21005763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:04:17Z","timestamp":1757765057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21005763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":24,"alternative-id":["S0006291X21005763"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.163","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanosensitive Piezo1 channel activation promotes ventilator-induced lung injury via disruption of endothelial junctions in ARDS rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}