{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:32:23Z","timestamp":1791635543229,"version":"4.3.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bbrc.2021.03.167","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T03:05:33Z","timestamp":1618283133000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Gut microbial short-chain fatty acids-mediated olfactory receptor 78 stimulation promotes anorexigenic gut hormone peptide YY secretion in mice"],"prefix":"10.1016","volume":"557","author":[{"given":"Akari","family":"Nishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-1787","authenticated-orcid":false,"given":"Junki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-145X","authenticated-orcid":false,"given":"Ikuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.03.167_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2021.03.167_bib2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nchembio.1535","article-title":"Gut microbiota-generated metabolites in animal health and disease","volume":"10","author":"Lee","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrmicro1817","article-title":"Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis","volume":"6","author":"Flint","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","article-title":"Short-chain fatty acids in control of body weight and insulin sensitivity","volume":"11","author":"Canfora","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2021.03.167_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ni0111-5","article-title":"Diet, gut microbiota and immune responses","volume":"12","author":"Maslowski","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota\u2013gut\u2013brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s42255-018-0017-4","article-title":"Microbial regulation of organismal energy homeostasis","volume":"1","author":"Cani","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbrc.2021.03.167_bib9","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Correa","year":"2016","journal-title":"Clin. Transl. Immunology"},{"key":"10.1016\/j.bbrc.2021.03.167_bib10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.03.167_bib11","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.03.167_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2021.03.167_bib13","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.2337\/db14-1938","article-title":"GPR43 potentiates beta-cell function in obesity","volume":"64","author":"McNelis","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2021.03.167_bib14","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/mi.2016.114","article-title":"Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43","volume":"10","author":"Wu","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib15","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.1016088108","article-title":"Short-chain fatty acids and ketones directly regulate sympathetic nervous system via GPR41","volume":"108","author":"Kimura","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.167_bib16","doi-asserted-by":"crossref","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41","volume":"105","author":"Samuel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.167_bib17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2021.03.167_bib18","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1073\/pnas.1215927110","article-title":"Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation","volume":"110","author":"Pluznick","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.167_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00441-015-2165-0","article-title":"Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon","volume":"361","author":"Fleischer","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrc.2021.03.167_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw8429","article-title":"Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice","volume":"367","author":"Kimura","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2021.03.167_bib21","doi-asserted-by":"crossref","first-page":"23813","DOI":"10.1073\/pnas.1912573116","article-title":"Ketone body receptor GPR43 regulates lipid metabolism under ketogenic condition","volume":"116","author":"Miyamoto","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.03.167_bib22","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1038\/s41467-019-11978-0","article-title":"Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids","volume":"10","author":"Miyamoto","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.03.167_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuron.2008.11.010","article-title":"Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse","volume":"61","author":"Bozza","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2021.03.167_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41598-017-18259-0","article-title":"SCFAs strongly stimulate PYY production in human enteroendocrine cells","volume":"8","author":"Larraufie","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2021.03.167_bib25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/j.2040-4603.2018.tb00038.x","article-title":"Role of short chain fatty acid receptors in intestinal physiology and pathophysiology","volume":"8","author":"Priyadarshini","year":"2018","journal-title":"Comp. Physiol."},{"key":"10.1016\/j.bbrc.2021.03.167_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fphys.2014.00420","article-title":"Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac\/PLC-\u03b5 pathway and modulated by endogenous H2S","volume":"5","author":"Bala","year":"2014","journal-title":"Front. Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21005805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21005805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:04:12Z","timestamp":1757765052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21005805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":26,"alternative-id":["S0006291X21005805"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.167","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbial short-chain fatty acids-mediated olfactory receptor 78 stimulation promotes anorexigenic gut hormone peptide YY secretion in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}