{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:18:33Z","timestamp":1789600713052,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.bbrc.2021.05.010","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T02:28:31Z","timestamp":1621304911000},"page":"65-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Baicalein inhibits RLS3-induced ferroptosis in melanocytes"],"prefix":"10.1016","volume":"561","author":[{"given":"Meng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-2127","authenticated-orcid":false,"given":"Yeqiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.05.010_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archderm.1977.01640010049006","article-title":"Prevalence of vitiligo. Epidemiological survey on the isle of bornholm, Denmark","volume":"113","author":"Howitz","year":"1977","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib2","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1365-4632.2011.05377.x","article-title":"A\u00a0review of the worldwide prevalence of vitiligo in children\/adolescents and adults","volume":"51","author":"Kr\u00fcger","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib3","doi-asserted-by":"crossref","first-page":"15011","DOI":"10.1038\/nrdp.2015.11","article-title":"Vitiligo","volume":"1","author":"Picardo","year":"2015","journal-title":"Nature reviews. Disease primers"},{"key":"10.1016\/j.bbrc.2021.05.010_bib4","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Revised classification\/nomenclature of vitiligo and related issues: the vitiligo global issues consensus conference","volume":"25","author":"Ezzedine","year":"2012","journal-title":"Pigment cell & melanoma research"},{"key":"10.1016\/j.bbrc.2021.05.010_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: a review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology (Basel, Switzerland)"},{"key":"10.1016\/j.bbrc.2021.05.010_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.05.010_bib7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.05.010_bib8","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.7150\/thno.32867","article-title":"Ferroptosis promotes photodynamic therapy: supramolecular photosensitizer-inducer nanodrug for enhanced cancer treatment","volume":"9","author":"Zhu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2021.05.010_bib9","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A\u00a0GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.05.010_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1600-0749.2007.00406.x","article-title":"Association of catalase T\/C exon 9 and glutathione peroxidase codon 200 polymorphisms in relation to their activities and oxidative stress with vitiligo susceptibility in Gujarat population","volume":"20","author":"Em","year":"2007","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.bbrc.2021.05.010_bib11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2016.03.052","article-title":"Identification of baicalein as a ferroptosis inhibitor by natural product library screening","volume":"473","author":"Xie","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.05.010_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3389\/fphar.2019.00638","article-title":"Baicalein exerts neuroprotective effects in FeCl(3)-induced posttraumatic epileptic seizures via suppressing ferroptosis","volume":"10","author":"Li","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bcp.2017.06.112","article-title":"Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death","volume":"140","author":"Probst","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2021.05.010_bib15","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3389\/fphar.2018.01371","article-title":"RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer","volume":"9","author":"Sui","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bbrc.2021.05.010_bib17","first-page":"1138","volume":"41","author":"Chen","year":"2021","journal-title":"Mechanisms of melanocyte death in vitiligo"},{"key":"10.1016\/j.bbrc.2021.05.010_bib18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2021.05.010_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1365-4632.2009.03998.x","article-title":"Antioxidant enzymes and lipid peroxidation at the tissue level in patients with stable and active vitiligo","volume":"48","author":"Dammak","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3389\/fphar.2017.00992","article-title":"The role of ferroptosis in cancer development and treatment response","volume":"8","author":"Lu","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fnins.2018.00466","article-title":"Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration","volume":"12","author":"Abdalkader","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2021.05.010_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/cns.13069","article-title":"Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice","volume":"25","author":"Xie","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbrc.2021.05.010_bib23","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.2174\/1389450119666180605112235","article-title":"Pathological roles of iron in cardiovascular disease","volume":"19","author":"Kobayashi","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbrc.2021.05.010_bib24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.05.010_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007811","article-title":"CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo","volume":"6","author":"Rashighi","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2021.05.010_bib26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/1873-3468.13631","article-title":"Inactivation of the glutathione peroxidase GPx4 by the ferroptosis-inducing molecule RSL3 requires the adaptor protein 14-3-3\u03b5","volume":"594","author":"Vu\u010dkovi\u0107","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2021.05.010_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2021.05.010_bib28","volume":"vol. 10","author":"Li","year":"2019"},{"key":"10.1016\/j.bbrc.2021.05.010_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1667\/RR15486.1","article-title":"Anti-Ferroptosis drug enhances total-body irradiation mitigation by drugs that block Apoptosis and necroptosis","volume":"193","author":"Thermozier","year":"2020","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbrc.2021.05.010_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ph12010026","article-title":"Curcumin and (-)- epigallocatechin-3-gallate protect murine MIN6 pancreatic beta-cells against iron toxicity and erastin-induced ferroptosis","volume":"12","author":"Kose","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbrc.2021.05.010_bib31","doi-asserted-by":"crossref","first-page":"9968","DOI":"10.1038\/s41598-017-07442-y","article-title":"Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2021.05.010_bib32","first-page":"3029810","article-title":"Glutathione peroxidase level in patients with vitiligo: a meta-analysis","author":"Xiao","year":"2016","journal-title":"BioMed research international 2016"},{"key":"10.1016\/j.bbrc.2021.05.010_bib33","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1158\/1535-7163.MCT-08-1030","article-title":"Two types of human malignant melanoma cell lines revealed by expression patterns of mitochondrial and survival-apoptosis genes: implications for malignant melanoma therapy","volume":"8","author":"Su","year":"2009","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.bbrc.2021.05.010_bib34","doi-asserted-by":"crossref","first-page":"116795","DOI":"10.1016\/j.lfs.2019.116795","article-title":"The neuroprotective effects of carvacrol on ischemia\/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation","volume":"235","author":"Guan","year":"2019","journal-title":"Life Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21007798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21007798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:06:01Z","timestamp":1757765161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21007798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":34,"alternative-id":["S0006291X21007798"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.05.010","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalein inhibits RLS3-induced ferroptosis in melanocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}