{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:07:21Z","timestamp":1790968041356,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06576"],"award-info":[{"award-number":["16H06576"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04972"],"award-info":[{"award-number":["19H04972"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H05028"],"award-info":[{"award-number":["20H05028"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.bbrc.2021.07.072","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T23:44:57Z","timestamp":1627429497000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator"],"prefix":"10.1016","volume":"571","author":[{"given":"Masashi","family":"Muramatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-3825","authenticated-orcid":false,"given":"Takeshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hokuto","family":"Shimoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miko","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Miyamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-1379","authenticated-orcid":false,"given":"Takashi","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.07.072_bib1","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1161\/ATVBAHA.120.315003","article-title":"Loss of down syndrome critical region-1 mediated-hypercholesterolemia accelerates corneal opacity via pathological neovessel formation","volume":"40","author":"Muramatsu","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2021.07.072_bib2","doi-asserted-by":"crossref","first-page":"100697","DOI":"10.1016\/j.jbc.2021.100697","article-title":"Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background","author":"Muramatsu","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jb\/mvu006","article-title":"Calcineurin-NFAT activation and DSCR-1 auto-inhibitory loop: how is homoeostasis regulated?","volume":"155","author":"Minami","year":"2014","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib4","doi-asserted-by":"crossref","first-page":"50537","DOI":"10.1074\/jbc.M406454200","article-title":"Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis","volume":"279","author":"Minami","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib5","first-page":"2257","article-title":"The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice","volume":"119","author":"Minami","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2021.07.072_bib6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nature08062","article-title":"Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1","volume":"459","author":"Baek","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.07.072_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/cas.13395","article-title":"Study on the tumor-induced angiogenesis using mathematical models","volume":"109","author":"Suzuki","year":"2018","journal-title":"Canc. Sci."},{"key":"10.1016\/j.bbrc.2021.07.072_bib8","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbrc.2019.02.086","article-title":"Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification","volume":"511","author":"Ito","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.07.072_bib9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jtbi.2018.11.023","article-title":"Critical roles of IkappaBalpha and RelA phosphorylation in transitional oscillation in NF-kappaB signaling module","volume":"462","author":"Hatanaka","year":"2019","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.bbrc.2021.07.072_bib10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.1071914","article-title":"The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation","volume":"298","author":"Hoffmann","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2021.07.072_bib11","doi-asserted-by":"crossref","first-page":"20503","DOI":"10.1074\/jbc.M513112200","article-title":"Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium","volume":"281","author":"Minami","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib12","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.celrep.2017.02.006","article-title":"Extracellular acidic pH activates the sterol regulatory element-binding protein 2 to promote tumor progression","volume":"18","author":"Kondo","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2021.07.072_bib13","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1007\/s10439-006-9179-4","article-title":"NFAT and NFkappaB activation in T lymphocytes: a model of differential activation of gene expression","volume":"34","author":"Fisher","year":"2006","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bbrc.2021.07.072_bib14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/msb.2013.19","article-title":"The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns","volume":"9","author":"Noguchi","year":"2013","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbrc.2021.07.072_bib15","doi-asserted-by":"crossref","first-page":"H697","DOI":"10.1152\/ajpheart.00744.2014","article-title":"Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells","volume":"308","author":"Jafarnejad","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2021.07.072_bib16","doi-asserted-by":"crossref","first-page":"65429","DOI":"10.18632\/oncotarget.11748","article-title":"Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy","volume":"7","author":"Schadler","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2021.07.072_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-5793(95)00207-P","article-title":"Characterization of the calcium-binding sites of calcineurin B","volume":"362","author":"Kakalis","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2021.07.072_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nsmb.2192","article-title":"Signal-dependent dynamics of transcription factor translocation controls gene expression","volume":"19","author":"Hao","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2021.07.072_bib19","doi-asserted-by":"crossref","first-page":"29435","DOI":"10.1074\/jbc.M506205200","article-title":"Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin\/nuclear factor of activated T cells-dependent pathway","volume":"280","author":"Cano","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib20","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1074\/jbc.270.9.4650","article-title":"Binding of human factor VIIa to tissue factor induces cytosolic Ca2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor","volume":"270","author":"R\u00f8ttingen","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0092-8674(00)80571-1","article-title":"Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT","volume":"96","author":"Crabtree","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.07.072_bib22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","article-title":"NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21","volume":"441","author":"Arron","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.07.072_bib23","doi-asserted-by":"crossref","first-page":"10884","DOI":"10.1074\/jbc.271.18.10884","article-title":"Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity","volume":"271","author":"Loh","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/382370a0","article-title":"Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4","volume":"382","author":"Shibasaki","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.07.072_bib25","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1073\/pnas.92.24.11205","article-title":"Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells","volume":"92","author":"Shaw","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2021.07.072_bib26","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1101\/gad.11.7.824","article-title":"Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction","volume":"11","author":"Beals","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2021.07.072_bib27","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1074\/jbc.273.22.13367","article-title":"Regulation of the calmodulin-stimulated protein phosphatase, calcineurin","volume":"273","author":"Klee","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.07.072_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/18473","article-title":"NF-AT activation requires suppression of Crm1-dependent export by calcineurin","volume":"398","author":"Zhu","year":"1999","journal-title":"Nature"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21011098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21011098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:09:51Z","timestamp":1757765391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21011098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":28,"alternative-id":["S0006291X21011098"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.07.072","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.07.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}