{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:11Z","timestamp":1786985051887,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K20424"],"award-info":[{"award-number":["JP16K20424"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03144"],"award-info":[{"award-number":["JP21H03144"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.bbrc.2021.09.067","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T12:56:29Z","timestamp":1633006589000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Tumor necrosis factor alpha regulates myogenesis to inhibit differentiation and promote proliferation in satellite cells"],"prefix":"10.1016","volume":"580","author":[{"given":"Tomohiko","family":"Shirakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thira","family":"Rojasawasthien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-4327","authenticated-orcid":false,"given":"Shoichiro","family":"Kokabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.09.067_bib1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Argiles","year":"2014","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2021.09.067_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib5","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.bbrc.2021.09.067_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phanu.2013.07.002","article-title":"Molecular targets of cancer cachexia: opportunities for pharmanutritional approaches","volume":"2","author":"Sharma","year":"2014","journal-title":"PharmaNutrition"},{"key":"10.1016\/j.bbrc.2021.09.067_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246275","article-title":"NF-kappaB signaling regulates physiological and pathological chondrogenesis","volume":"20","author":"Jimi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2021.09.067_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.tem.2016.03.002","article-title":"Cytokine signaling in skeletal muscle wasting","volume":"27","author":"Zhou","year":"2016","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib9","doi-asserted-by":"crossref","first-page":"C320","DOI":"10.1152\/ajpcell.1999.277.2.C320","article-title":"Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury","volume":"277","author":"Thaloor","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib10","doi-asserted-by":"crossref","first-page":"C1179","DOI":"10.1152\/ajpcell.00062.2005","article-title":"Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscle","volume":"289","author":"Chen","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0092-8674(79)90317-9","article-title":"Multiple new phenotypes induced in 10T1\/2 and 3T3 cells treated with 5-azacytidine","volume":"17","author":"Taylor","year":"1979","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.09.067_bib12","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1128\/MCB.19.8.5785","article-title":"NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1","volume":"19","author":"Guttridge","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib13","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1126\/science.289.5488.2363","article-title":"NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia","volume":"289","author":"Guttridge","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2021.09.067_bib14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1096\/fj.00-0463","article-title":"Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB","volume":"15","author":"Langen","year":"2001","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2021.09.067_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ydbio.2009.10.005","article-title":"Muscle satellite cells are a functionally heterogeneous population in both somite-derived and branchiomeric muscles","volume":"337","author":"Ono","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbrc.2013.07.054","article-title":"TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells","volume":"438","author":"Kokabu","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.09.067_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbrc.2015.02.123","article-title":"Promotion of insulin-induced glucose uptake in C2C12 myotubes by osteocalcin","volume":"459","author":"Tsuka","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.09.067_bib18","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1074\/jbc.M116.774570","article-title":"The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor","volume":"292","author":"Kokabu","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.09.067_bib19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2144\/96216bm10","article-title":"Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression","volume":"21","author":"Goldman","year":"1996","journal-title":"Biotechniques"},{"key":"10.1016\/j.bbrc.2021.09.067_bib20","first-page":"2345","article-title":"Oral administration of geranylgeraniol rescues denervation-induced muscle atrophy via suppression of atrogin-1","volume":"34","author":"Miyawaki","year":"2020","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.bbrc.2021.09.067_bib21","first-page":"883","article-title":"Vignacyanidin polyphenols isolated from vigna angularis bean promote osteoblast differentiation","volume":"35","author":"Rojasawasthien","year":"2021","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.bbrc.2021.09.067_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbrc.2021.09.067_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103089","article-title":"Daily oral administration of protease-treated royal jelly protects against denervation-induced skeletal muscle atrophy","volume":"12","author":"Shirakawa","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2021.09.067_bib24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bbrc.2015.10.142","article-title":"Muscle regulatory factors regulate T1R3 taste receptor expression","volume":"468","author":"Kokabu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.09.067_bib25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/2211-5463.12347","article-title":"BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling","volume":"8","author":"Kokabu","year":"2018","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbrc.2021.09.067_bib26","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1111\/febs.12372","article-title":"Lying low but ready for action: the quiescent muscle satellite cell","volume":"280","author":"Montarras","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2021.09.067_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.09.067_bib28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1083\/jcb.200707179","article-title":"IKK\/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis","volume":"180","author":"Bakkar","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1096\/fj.03-0251com","article-title":"Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization","volume":"18","author":"Langen","year":"2004","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2021.09.067_bib30","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1128\/MCB.15.7.3823","article-title":"MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation","volume":"15","author":"Guo","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib31","doi-asserted-by":"crossref","first-page":"23224","DOI":"10.1074\/jbc.M801379200","article-title":"Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor","volume":"283","author":"Alter","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.09.067_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/523158e","article-title":"Cytokine anniversary: TNF trailblazers five centuries apart","volume":"523","author":"Libert","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.09.067_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13539-012-0074-6","article-title":"Molecular and cellular mechanisms of skeletal muscle atrophy: an update","volume":"3","author":"Fanzani","year":"2012","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.bbrc.2021.09.067_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12032-015-0497-y","article-title":"The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia","volume":"32","author":"Bilir","year":"2015","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bbrc.2021.09.067_bib35","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1210\/jc.2013-1502","article-title":"Two weeks of reduced activity decreases leg lean mass and induces \"anabolic resistance\" of myofibrillar protein synthesis in healthy elderly","volume":"98","author":"Breen","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2021.09.067_bib36","first-page":"5052","article-title":"TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?","volume":"24","author":"Remels","year":"2010","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2021.09.067_bib37","doi-asserted-by":"crossref","first-page":"17437","DOI":"10.1074\/jbc.274.25.17437","article-title":"Insulin-like growth factor-II, phosphatidylinositol 3-kinase, nuclear factor-kappaB and inducible nitric-oxide synthase define a common myogenic signaling pathway","volume":"274","author":"Kaliman","year":"1999","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21013668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21013668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:11:09Z","timestamp":1757765469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21013668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":37,"alternative-id":["S0006291X21013668"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.09.067","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor necrosis factor alpha regulates myogenesis to inhibit differentiation and promote proliferation in satellite cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.09.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}