{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:37:20Z","timestamp":1787693840113,"version":"build-2784847793"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900417"],"award-info":[{"award-number":["81900417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000442"],"award-info":[{"award-number":["82000442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bbrc.2021.10.013","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T08:01:12Z","timestamp":1633939272000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis"],"prefix":"10.1016","volume":"581","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8208-9325","authenticated-orcid":false,"given":"Yunzhang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.10.013_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.matbio.2018.03.021","article-title":"Idiopathic pulmonary fibrosis: epithelial-mesenchymal interactions and emerging therapeutic targets","volume":"71\u201372","author":"Hewlett","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrc.2021.10.013_bib2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1164\/ajrccm.157.4.9707039","article-title":"Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification","volume":"157","author":"Katzenstein","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2021.10.013_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072269","article-title":"Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis","volume":"21","author":"Parimon","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2021.10.013_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF02034932","article-title":"Mechanisms of bleomycin-induced lung damage","volume":"65","author":"Hay","year":"1991","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrc.2021.10.013_bib5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2021.10.013_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/01902148.2014.979516","article-title":"The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis","volume":"41","author":"Williamson","year":"2015","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.bbrc.2021.10.013_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/cr.2010.182","article-title":"NF-\u03baB signaling pathways regulated by CARMA family of scaffold proteins","volume":"21","author":"Blonska","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2021.10.013_bib8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4049\/jimmunol.1402983","article-title":"CARMA3 is critical for the initiation of allergic airway inflammation","volume":"195","author":"Causton","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2021.10.013_bib9","doi-asserted-by":"crossref","first-page":"25880","DOI":"10.1074\/jbc.C110.109421","article-title":"The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis","volume":"285","author":"McAllister-Lucas","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.10.013_bib10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1165\/rcmb.2017-0181OC","article-title":"CARMA3 mediates allergic lung inflammation in response to Alternaria alternata","volume":"59","author":"Causton","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2021.10.013_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.yexmp.2015.10.004","article-title":"CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-\u043aB and suppressing the P38 MAPK signaling pathway","volume":"100","author":"Xia","year":"2016","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbrc.2021.10.013_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13277-013-1018-2","article-title":"CARMA3 is overexpressed in human glioma and promotes cell invasion through MMP9 regulation in A172 cell line","volume":"35","author":"Feng","year":"2014","journal-title":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"key":"10.1016\/j.bbrc.2021.10.013_bib13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/dvdy.24541","article-title":"Epithelial-mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease","volume":"247","author":"Jolly","year":"2018","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.bbrc.2021.10.013_bib14","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa1402584","article-title":"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis","volume":"370","author":"Richeldi","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2021.10.013_bib15","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A\u00a0phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"King","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2021.10.013_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.rmed.2018.12.015","article-title":"Inflammation and immunity in IPF pathogenesis and treatment","volume":"147","author":"Heukels","year":"2019","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbrc.2021.10.013_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1073\/pnas.0601947103","article-title":"CARMA3\/Bcl10\/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells","volume":"104","author":"McAllister-Lucas","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.10.013_bib18","doi-asserted-by":"crossref","first-page":"105802","DOI":"10.1016\/j.biocel.2020.105802","article-title":"The extracellular matrix and mechanotransduction in pulmonary fibrosis","volume":"126","author":"Deng","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2021.10.013_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","article-title":"Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy","volume":"134","author":"Selman","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2021.10.013_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40360-018-0204-7","article-title":"Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition","volume":"19","author":"Kyung","year":"2018","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.bbrc.2021.10.013_bib21","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.onc.1209808","article-title":"NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2","volume":"26","author":"Chua","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2021.10.013_bib22","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41419-020-03178-2","article-title":"Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-\u03baB\/NLRP3-mediated epithelial-mesenchymal transition and inflammation","volume":"11","author":"Peng","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21014133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21014133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:11:43Z","timestamp":1757765503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21014133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":22,"alternative-id":["S0006291X21014133"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.10.013","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}