{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:04:12Z","timestamp":1777349052946,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"am","delay-in-days":327,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbrc.2021.11.045","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T10:49:55Z","timestamp":1637232595000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effect of topical application of lipopolysaccharide on contact hypersensitivity"],"prefix":"10.1016","volume":"586","author":[{"given":"Manami","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Kohchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Inagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hara-Chikuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.11.045_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","article-title":"Innate immunity to intracellular LPS","volume":"20","author":"Rathinam","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tim.2020.09.008","article-title":"Border control: regulating LPS biogenesis","volume":"29","author":"Guest","year":"2021","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.bjp.0701649","article-title":"Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung","volume":"123","author":"Goncalves de Moraes","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib4","first-page":"1388","article-title":"A\u00a0mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide","volume":"6","author":"Williams","year":"2013","journal-title":"Disease Models & Mechanisms"},{"key":"10.1016\/j.bbrc.2021.11.045_bib5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrlander","year":"2002","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2021.11.045_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.11.045_bib7","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.4103\/1673-5374.308067","article-title":"Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia","volume":"16","author":"Mizobuchi","year":"2021","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.bbrc.2021.11.045_bib8","first-page":"4501","article-title":"Immunopotentiator from Pantoea agglomerans prevents atopic dermatitis induced by dermatophagoides farinae extract in NC\/Nga mouse","volume":"35","author":"Wakame","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2021.11.045_bib9","first-page":"109","article-title":"The effect of lipopolysaccharide-containing moisturizing cream on skin Care in patients with mild atopic dermatitis","volume":"33","author":"Nakai","year":"2019","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.bbrc.2021.11.045_bib10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/jid.2012.284","article-title":"Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis","volume":"133","author":"Honda","year":"2013","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jaci.2014.03.009","article-title":"Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response","volume":"134","author":"Dhingra","year":"2014","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/intimm\/dxz005","article-title":"Antigen presentation and adaptive immune responses in skin","volume":"31","author":"Honda","year":"2019","journal-title":"Int. Immunol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The immunological anatomy of the skin","volume":"19","author":"Kabashima","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib15","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1084\/jem.20091527","article-title":"External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers","volume":"206","author":"Kubo","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2021.11.045_bib16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.immuni.2012.07.019","article-title":"Two distinct types of Langerhans cells populate the skin during steady state and inflammation","volume":"37","author":"Sere","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2021.11.045_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1096\/fj.11-186627","article-title":"Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells","volume":"26","author":"Hara-Chikuma","year":"2012","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.bbrc.2021.11.045_bib18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/1523-1747.ep12326625","article-title":"Phenotypic and functional heterogeneity among murine epidermal-derived dendritic cell clones","volume":"105","author":"Xu","year":"1995","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00418-009-0674-1","article-title":"Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells","volume":"133","author":"Kamekura","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-5699(97)01186-9","article-title":"Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity","volume":"19","author":"Grabbe","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/j.bbrc.2021.11.045_bib21","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1084\/jem.20112398","article-title":"Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake","volume":"209","author":"Hara-Chikuma","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2021.11.045_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65412","article-title":"Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population","volume":"10","author":"Sheng","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.bbrc.2021.11.045_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2567.2006.02335.x","article-title":"Drinking a lot is good for dendritic cells","volume":"117","author":"Norbury","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2021.11.045_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.0022-202X.2003.22116.x","article-title":"Differential expression and function of Toll-like receptors in Langerhans cells: comparison with splenic dendritic cells","volume":"122","author":"Mitsui","year":"2004","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib25","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.4049\/jimmunol.177.11.7959","article-title":"Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria","volume":"177","author":"Flacher","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.yadr.2008.09.004","article-title":"Toll-like receptors in skin","volume":"24","author":"Miller","year":"2008","journal-title":"Adv. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1468-3083.2011.04049.x","article-title":"Toll-like receptors and skin","volume":"25","author":"Ermertcan","year":"2011","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol. : JEADV"},{"key":"10.1016\/j.bbrc.2021.11.045_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2567.2005.02122.x","article-title":"Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes","volume":"114","author":"Kollisch","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2021.11.045_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.jid.5700530","article-title":"Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9","volume":"127","author":"Lebre","year":"2007","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/jid.2012.267","article-title":"Toll-like receptor 4 has an essential role in early skin wound healing","volume":"133","author":"Chen","year":"2013","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.045_bib31","series-title":"Nutrition for Healthy Skin: Strategies for Clinical and Cosmetic Practice","first-page":"35","article-title":"Skin barrier function","author":"Elias","year":"2011"},{"key":"10.1016\/j.bbrc.2021.11.045_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fgene.2018.00247","article-title":"Biomarkers of cellular senescence and skin aging","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbrc.2021.11.045_bib33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nri3683","article-title":"The origins and functions of dendritic cells and macrophages in the skin","volume":"14","author":"Malissen","year":"2014","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21015564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21015564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:13:09Z","timestamp":1757765589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21015564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"alternative-id":["S0006291X21015564"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.11.045","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of topical application of lipopolysaccharide on contact hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.11.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}