{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:00:38Z","timestamp":1760623238096,"version":"3.44.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007179","name":"Advanced Centre for Treatment, Research and Education in Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Government of India Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR8351\/MED\/30\/995\/2013"],"award-info":[{"award-number":["BT\/PR8351\/MED\/30\/995\/2013"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbrc.2021.11.071","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T15:03:58Z","timestamp":1637334238000},"page":"14-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice"],"prefix":"10.1016","volume":"586","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-980X","authenticated-orcid":false,"given":"Rahul","family":"Raghavan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navami","family":"Koyande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Beher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Chetlangia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukda","family":"Ramadwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shital","family":"Pawade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-0342","authenticated-orcid":false,"given":"Rahul","family":"Thorat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0645-0435","authenticated-orcid":false,"given":"Jolanda","family":"van Hengel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-6977","authenticated-orcid":false,"given":"Tetyana","family":"Sklyarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans","family":"van Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorab N.","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.11.071_bib1","series-title":"Colorectal Cancer - Diagnosis, Screening and Management","first-page":"57","article-title":"Acquired and intrinsic resistance to colorectal cancer treatment","author":"Briffa","year":"2018"},{"key":"10.1016\/j.bbrc.2021.11.071_bib2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/1098-2264(199611)17:3<194::AID-GCC2870170302>3.0.CO;2-E","article-title":"Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse","volume":"17","author":"Luongo","year":"1996","journal-title":"Gene Chromosome Cancer"},{"key":"10.1016\/j.bbrc.2021.11.071_bib3","first-page":"5947","article-title":"Loss of Apc+ in intestinal adenomas from Min mice","volume":"54","author":"Luongo","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2021.11.071_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.celrep.2012.07.003","article-title":"Luminal iron levels govern intestinal tumorigenesis after Apc loss in\u00a0vivo","volume":"2","author":"Radulescu","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2021.11.071_bib5","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00432-019-02883-6","article-title":"The application of Apc(Min\/+) mouse model in colorectal tumor researches","volume":"145","author":"Ren","year":"2019","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1083\/jcb.200303036","article-title":"Defining desmosomal plakophilin-3 interactions","volume":"161","author":"Bonne","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib7","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1242\/jcs.112.14.2265","article-title":"Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells","volume":"112","author":"Bonne","year":"1999","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2021.11.071_bib8","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00018-010-0531-3","article-title":"E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly","volume":"68","author":"Gosavi","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2021.11.071_bib9","first-page":"291","article-title":"Plakophilin 3 - a novel cell type specific desmosomal plaque protein","volume":"64","author":"Schmidt","year":"1999","journal-title":"Differ.Res. Biol. Divers."},{"key":"10.1016\/j.bbrc.2021.11.071_bib10","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/sj.jid.5701189","article-title":"Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation","volume":"128","author":"Sklyarova","year":"2008","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib11","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1002\/eji.201445440","article-title":"Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice","volume":"45","author":"Sklyarova","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib12","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.febslet.2007.03.026","article-title":"The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression","volume":"581","author":"Aigner","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2021.11.071_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-1596-6-1","article-title":"Expression of plakophilins (PKP1, PKP2, and PKP3) in gastric cancers","volume":"6","author":"Demirag","year":"2011","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib14","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1007\/s12032-011-0071-1","article-title":"Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers","volume":"29","author":"Demirag","year":"2012","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0046-8177(03)00174-6","article-title":"Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters","volume":"34","author":"Papagerakis","year":"2003","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.bbrc.2021.11.071_bib16","doi-asserted-by":"crossref","first-page":"240 e241","DOI":"10.1016\/j.urology.2011.08.049","article-title":"Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer","volume":"79","author":"Takahashi","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.bbrc.2021.11.071_bib17","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/ijc.23797","article-title":"Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis","volume":"123","author":"Kundu","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2021.11.071_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.yexcr.2018.05.026","article-title":"Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation","volume":"369","author":"Basu","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2021.11.071_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123979","article-title":"MMP7 is required to mediate cell invasion and tumor formation upon plakophilin3 loss","volume":"10","author":"Basu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2021.11.071_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038561","article-title":"Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis","volume":"7","author":"Khapare","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2021.11.071_bib21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/ijc.33711","article-title":"Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer","volume":"149","author":"Chaudhary","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2021.11.071_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021975","article-title":"Lentiviral mediated transgenesis by in\u00a0vivo manipulation of spermatogonial stem cells","volume":"6","author":"Sehgal","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2021.11.071_bib23","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2021.11.071_bib24","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.biopha.2014.10.019","article-title":"Colon cancer: cancer stem cells markers, drug resistance and treatment","volume":"68","author":"Kozovska","year":"2014","journal-title":"Biomed. Pharmacother."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21015886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21015886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:12:09Z","timestamp":1757765529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21015886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":24,"alternative-id":["S0006291X21015886"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.11.071","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.11.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}