{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:05:36Z","timestamp":1790481936426,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007492","name":"Baylor University","doi-asserted-by":"publisher","award":["kq2023"],"award-info":[{"award-number":["kq2023"]}],"id":[{"id":"10.13039\/100007492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbrc.2021.11.083","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T10:43:21Z","timestamp":1637750601000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52\/PERLECAN"],"prefix":"10.1016","volume":"586","author":[{"given":"Zhongqiang","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianzijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wilsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-3646","authenticated-orcid":false,"given":"Myeongwoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.11.083_bib1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1083\/jcb.201109041","article-title":"The evolution of metazoan extracellular matrix","volume":"196","author":"Hynes","year":"2012","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2021.11.083_bib2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.cellbio.12.1.697","article-title":"RGD and other recognition sequences for integrins","volume":"12","author":"Ruoslahti","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"Pt 3","key":"10.1016\/j.bbrc.2021.11.083_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj3020625","article-title":"The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices","volume":"302","author":"Iozzo","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2021.11.083_bib4","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.147.5.1109","article-title":"Perlecan maintains the integrity of cartilage and some basement membranes","volume":"147","author":"Costell","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2021.11.083_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R","article-title":"Form and function: the laminin family of heterotrimers","volume":"218","author":"Colognato","year":"2000","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.bbrc.2021.11.083_bib6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.119.4.945","article-title":"Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan","volume":"119","author":"Hayashi","year":"1992","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2021.11.083_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0945-053X(94)90183-X","article-title":"Perlecan: a gem of a proteoglycan","volume":"14","author":"Iozzo","year":"1994","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrc.2021.11.083_bib8","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1091\/mbc.10.10.3205","article-title":"Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan\/UNC-52 in Caenorhabditis elegans","volume":"10","author":"Mullen","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2021.11.083_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/bst0290171","article-title":"UNC-52\/perlecan isoform diversity and function in Caenorhabditis elegans","volume":"29","author":"Rogalski","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrc.2021.11.083_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/genetics\/139.1.159","article-title":"Mutations in the unc-52 gene responsible for body wall muscle defects in adult Caenorhabditis elegans are located in alternatively spliced exons","volume":"139","author":"Rogalski","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2021.11.083_bib11","first-page":"2020","article-title":"Two alleles of unc-52 locus disrupting potential cell-binding motif of UNC-52","author":"Wilsey","year":"2020","journal-title":"MicroPubl Biol"},{"key":"10.1016\/j.bbrc.2021.11.083_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1534\/genetics.115.179382","article-title":"High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-Cas9 Ribonucleoprotein Complexes","volume":"201","author":"Paix","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2021.11.083_bib13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1534\/genetics.114.169730","article-title":"Efficient marker-free recovery of custom genetic modifications with CRISPR\/Cas9 in Caenorhabditis elegans","volume":"198","author":"Arribere","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2021.11.083_bib14","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/s41596-020-0321-9","article-title":"Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform","volume":"15","author":"Koopman","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2021.11.083_bib15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1083\/jcb.124.4.475","article-title":"Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations","volume":"124","author":"Williams","year":"1994","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.bbrc.2021.11.083_bib16","series-title":"Genetic Suppression","first-page":"1","author":"Hodgkin","year":"2005"},{"key":"10.1016\/j.bbrc.2021.11.083_bib17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1534\/genetics.115.182162","article-title":"CRISPR-based methods for Caenorhabditis elegans genome engineering","volume":"202","author":"Dickinson","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2021.11.083_bib18","series-title":"Isolation and Functional Analysis of Caenorhabditis elegans Integrin Bpat-3","author":"Gettner","year":"1994"},{"key":"10.1016\/j.bbrc.2021.11.083_bib19","doi-asserted-by":"crossref","first-page":"36404","DOI":"10.1074\/jbc.M105795200","article-title":"Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads","volume":"276","author":"Lee","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.11.083_bib20","series-title":"Localization and Function of UNC-52\/Perlecan Isoforms in the Nematode Caenorhabditis elegans, Genetics","first-page":"166","author":"Mullen","year":"1998"},{"key":"10.1016\/j.bbrc.2021.11.083_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.devcel.2009.06.006","article-title":"Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans","volume":"17","author":"Hagedorn","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2021.11.083_bib22","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1242\/jcs.00705","article-title":"Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans","volume":"116","author":"Cram","year":"2003","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2021.11.083_bib23","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1083\/jcb.101.4.1532","article-title":"Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization","volume":"101","author":"Francis","year":"1985","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.bbrc.2021.11.083_bib24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cm.21410","article-title":"High-resolution imaging of muscle attachment structures in Caenorhabditis elegans","volume":"74","author":"Qadota","year":"2017","journal-title":"Cytoskeleton (Hoboken)"},{"key":"10.1016\/j.bbrc.2021.11.083_bib25","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1242\/dev.125.9.1679","article-title":"The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila","volume":"125","author":"Bunch","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2021.11.083_bib26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/349707a0","article-title":"Embryonic lethality caused by mutations in basement membrane collagen of C.\u00a0elegans","volume":"349","author":"Guo","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.11.083_bib27","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1083\/jcb.129.4.1127","article-title":"Characterization of bpat-3 heterodimers, a family of essential integrin receptors in C.\u00a0elegans","volume":"129","author":"Gettner","year":"1995","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.bbrc.2021.11.083_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1083\/jcb.144.1.45","article-title":"A\u00a0conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans","volume":"144","author":"Hobert","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2021.11.083_bib29","first-page":"1","article-title":"Sarcomere assembly in C. elegans muscle","author":"Moerman","year":"2006","journal-title":"WormBook"},{"key":"10.1016\/j.bbrc.2021.11.083_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1083\/jcb.200703021","article-title":"The RGD motif in fibronectin is essential for development but dispensable for fibril assembly","volume":"178","author":"Takahashi","year":"2007","journal-title":"J.\u00a0Cell Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:13:36Z","timestamp":1757765616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21016089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"alternative-id":["S0006291X21016089"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.11.083","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52\/PERLECAN","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.11.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}