{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:23:42Z","timestamp":1759991022159,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K09023","16H05293","21K07922"],"award-info":[{"award-number":["15K09023","16H05293","21K07922"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbrc.2021.12.011","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T01:41:22Z","timestamp":1638754882000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Gender-specific development of experimental autoimmune cholangitis induced by double-stranded RNA"],"prefix":"10.1016","volume":"588","author":[{"given":"Shunin","family":"Someya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1127-2218","authenticated-orcid":false,"given":"Kazuyoshi","family":"Kon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-6712","authenticated-orcid":false,"given":"Shunhei","family":"Yamashina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-8686","authenticated-orcid":false,"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-0840","authenticated-orcid":false,"given":"Kenichi","family":"Ikejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.12.011_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","author":"European Association for the Study of the Liver","year":"2017","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary biliary cholangitis: 2018 practice guidance from the American association for the study of liver diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib3","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1053\/j.gastro.2015.08.031","article-title":"Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis","volume":"149","author":"Beuers","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib4","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1053\/gast.2000.20197","article-title":"Epidemiology and natural history of primary biliary cirrhosis in a US community","volume":"119","author":"Kim","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2188\/jea.17.210","article-title":"Comparison of the clinical features of Japanese patients with primary biliary cirrhosis in 1999 and 2004: utilization of clinical data when patients applied to receive public financial aid","volume":"17","author":"Sakauchi","year":"2007","journal-title":"J.\u00a0Epidemiol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.autrev.2014.01.041","article-title":"The diagnosis of primary biliary cirrhosis","volume":"13","author":"Bowlus","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bbrc.2021.12.011_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver--from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2174\/187152812803589976","article-title":"Innate immunity in the pathogenesis of cholangiopathy: a recent update","volume":"11","author":"Harada","year":"2012","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.bbrc.2021.12.011_bib10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A\u00a0family of human receptors structurally related to Drosophila Toll","volume":"95","author":"Rock","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.12.011_bib11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2021.12.011_bib12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1073\/pnas.022637199","article-title":"mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties","volume":"99","author":"Kang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.12.011_bib13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib14","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1073\/pnas.58.3.1004","article-title":"Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes","volume":"58","author":"Field","year":"1967","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.12.011_bib15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1478-3231.2005.01043.x","article-title":"Early development of primary biliary cirrhosis in female C57BL\/6 mice because of poly I:C administration","volume":"25","author":"Okada","year":"2005","journal-title":"Liver Int."},{"key":"10.1016\/j.bbrc.2021.12.011_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2249.2002.01881.x","article-title":"A\u00a0novel autoimmune pancreatitis model in MRL mice treated with polyinosinic:polycytidylic acid","volume":"129","author":"Qu","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-0625.2010.01208.x","article-title":"Double-stranded RNA induces melanocyte death via activation of Toll-like receptor 3","volume":"20","author":"Yu","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/hep.510310119","article-title":"Estrogen is involved in early alcohol-induced liver injury in a rat enteral feeding model","volume":"31","author":"Yin","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ygcen.2011.11.014","article-title":"Methods for long-term 17beta-estradiol administration to mice","volume":"175","author":"Ingberg","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1152\/physiolgenomics.00062.2005","article-title":"Serum alkaline phosphatase activity is regulated by a chromosomal region containing the alkaline phosphatase 2 gene (Akp2) in C57BL\/6J and DBA\/2J mice","volume":"23","author":"Foreman","year":"2005","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.bbrc.2021.12.011_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1034\/j.1600-0528.2002.017402.x","article-title":"Primary biliary cirrhosis: an orchestrated immune response against epithelial cells","volume":"174","author":"Gershwin","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2021.12.011_bib22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbi.2007.10.005","article-title":"Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats","volume":"22","author":"Hannah","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbrc.2021.12.011_bib23","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1002\/hep.1840360706","article-title":"Natural history of chronic hepatitis C","volume":"36","author":"Seeff","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/hep.510290351","article-title":"Sex and hepatic fibrosis","volume":"29","author":"Bissell","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib25","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1136\/gut.2005.078147","article-title":"Higher clearance of hepatitis C virus infection in females compared with males","volume":"55","author":"Bakr","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2021.12.011_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00705-015-2703-9","article-title":"Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection: a Japanese cross-sectional study","volume":"161","author":"Ikezaki","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.bbrc.2021.12.011_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archinte.158.2.177","article-title":"Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection","volume":"158","author":"Hayashi","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbrc.2021.12.011_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s12072-012-9349-4","article-title":"Response to peginterferon-alpha 2b and ribavirin in Japanese patients with chronic hepatitis C genotype 1","volume":"7","author":"Miyauchi","year":"2013","journal-title":"Hepatol Int"},{"key":"10.1016\/j.bbrc.2021.12.011_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.whi.2015.02.008","article-title":"Effect of gender on the response to hepatitis C treatment in an inner-city population","volume":"25","author":"Simoes","year":"2015","journal-title":"Wom. Health Issues"},{"key":"10.1016\/j.bbrc.2021.12.011_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ccr.2013.11.011","article-title":"Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma","volume":"25","author":"Hou","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2021.12.011_bib31","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/hep.31459","article-title":"Intestinal virome in patients with alcoholic hepatitis","volume":"72","author":"Jiang","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib32","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1053\/j.gastro.2020.07.005","article-title":"Intestinal virome signature associated with severity of nonalcoholic fatty liver disease","volume":"159","author":"Lang","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2021.12.011_bib33","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/cvr\/cvaa284","article-title":"Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities","volume":"116","author":"Bienvenu","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2021.12.011_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.15585\/mmwr.mm7008e3","article-title":"First month of COVID-19 vaccine safety monitoring - United States, december 14, 2020-january 13, 2021","volume":"70","author":"Gee","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:13:15Z","timestamp":1757765595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21016466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":34,"alternative-id":["S0006291X21016466"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.011","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gender-specific development of experimental autoimmune cholangitis induced by double-stranded RNA","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}