{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:48:48Z","timestamp":1788544128677,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20191324"],"award-info":[{"award-number":["BK20191324"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbrc.2021.12.017","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T19:03:47Z","timestamp":1638903827000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Obesity induced Ext1 reduction mediates the occurrence of NAFLD"],"prefix":"10.1016","volume":"589","author":[{"given":"Mengxiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.12.017_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s13238-017-0436-0","article-title":"New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"9","author":"Zhang","year":"2018","journal-title":"Protein & cell"},{"key":"10.1016\/j.bbrc.2021.12.017_bib2","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.017_bib3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrgastro.2016.3","article-title":"Management of NAFLD: a stage-based approach","volume":"13","author":"Rinella","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.017_bib4","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2021.12.017_bib5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.gtc.2016.07.003","article-title":"Nonalcoholic fatty liver disease: pathophysiology and management","volume":"45","author":"Carr","year":"2016","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.bbrc.2021.12.017_bib6","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.017_bib7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2021.12.017_bib8","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1136\/gutjnl-2017-313778","article-title":"Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase\/hydrogen sulfide pathway","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2021.12.017_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030494","article-title":"Lonicera caerulea extract attenuates non-alcoholic fatty liver disease in free fatty acid-induced HepG2 hepatocytes and in high fat diet-fed mice","volume":"11","author":"Park","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2021.12.017_bib10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1172\/JCI76738","article-title":"Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease","volume":"125","author":"Jiang","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2021.12.017_bib11","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/hep.31568","article-title":"Activating adenosine monophosphate-activated protein kinase mediates fibroblast growth factor 1 protection from nonalcoholic fatty liver disease in mice","volume":"73","author":"Lin","year":"2021","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2021.12.017_bib12","first-page":"3236","article-title":"Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice","volume":"119","author":"Stanford","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2021.12.017_bib13","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2021.12.017_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00125-014-3451-1","article-title":"GLUT2, glucose sensing and glucose homeostasis","volume":"58","author":"Thorens","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2021.12.017_bib15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.017_bib16","doi-asserted-by":"crossref","first-page":"e1179","DOI":"10.1038\/cddis.2014.162","article-title":"Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD","volume":"5","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2021.12.017_bib17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1172\/JCI13737","article-title":"The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins","volume":"108","author":"Duncan","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2021.12.017_bib18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.matbio.2018.05.010","article-title":"The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis","volume":"71\u201372","author":"Gordts","year":"2018","journal-title":"Matrix Biol. Int. J.Soc.Matrix Biol"},{"key":"10.1016\/j.bbrc.2021.12.017_bib19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1194\/jlr.M053504","article-title":"Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans","volume":"56","author":"Mooij","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2021.12.017_bib20","article-title":"Hepatocyte TMEM16A deletion retards NAFLD progression by ameliorating hepatic glucose metabolic disorder","volume":"7","author":"Guo","year":"2020","journal-title":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.bbrc.2021.12.017_bib21","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2021.12.017_bib22","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1172\/JCI65538","article-title":"Hepatic glucose sensing is required to preserve \u03b2 cell glucose competence","volume":"123","author":"Seyer","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2021.12.017_bib23","doi-asserted-by":"crossref","first-page":"10455","DOI":"10.1074\/jbc.M117.786525","article-title":"Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice","volume":"292","author":"Irimia","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.12.017_bib24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fgene.2014.00242","article-title":"Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases","volume":"5","author":"Guo","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbrc.2021.12.017_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2147\/HMER.S98120","article-title":"Autophagy: a new target for nonalcoholic fatty liver disease therapy","volume":"8","author":"Mao","year":"2016","journal-title":"Hepatic Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:12:57Z","timestamp":1757765577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21016521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":25,"alternative-id":["S0006291X21016521"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.017","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity induced Ext1 reduction mediates the occurrence of NAFLD","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}