{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:43:08Z","timestamp":1790120588911,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-04-00130"],"award-info":[{"award-number":["20-04-00130"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbrc.2021.12.051","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T02:01:11Z","timestamp":1639706471000},"page":"29-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ"],"prefix":"10.1016","volume":"588","author":[{"given":"Galina V.","family":"Kopylova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9554-5756","authenticated-orcid":false,"given":"Valentina Y.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia M.","family":"Kochurova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Matyushenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey Y.","family":"Bershitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil V.","family":"Shchepkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.12.051_bib1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/europace\/euw161","article-title":"EHRA\/HRS\/APHRS\/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication","volume":"18","author":"Goette","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.bbrc.2021.12.051_bib2","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1038\/s41598-021-84133-9","article-title":"Disproportionate left atrial myopathy in heart failure with preserved ejection fraction among participants of the PROMIS-HFpEF study","volume":"11","author":"Patel","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2021.12.051_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.yjmcc.2017.11.020","article-title":"Progressive impairment of atrial myocyte function during left ventricular hypertrophy and heart failure","volume":"114","author":"Pluteanu","year":"2018","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/diagnostics11030449","article-title":"Latest insights into mechanisms behind atrial cardiomyopathy: it is not always about ventricular function","volume":"11","author":"Dmour","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.bbrc.2021.12.051_bib5","article-title":"Characterization, pathogenesis, and clinical implications of inflammation-related atrial myopathy as an important cause of atrial fibrillation","volume":"9","author":"Packer","year":"2020","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.bbrc.2021.12.051_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jchf.2019.03.005","article-title":"Heart failure and atrial fibrillation, like fire and fury","volume":"7","author":"Carlisle","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.bbrc.2021.12.051_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12968-017-0420-0","article-title":"Left atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy","volume":"19","author":"Farhad","year":"2017","journal-title":"J.\u00a0Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.bbrc.2021.12.051_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12947-020-00233-y","article-title":"Contribution of sarcomere gene mutations to left atrial function in patients with hypertrophic cardiomyopathy","volume":"19","author":"Chung","year":"2021","journal-title":"Cardiovasc. Ultrasound"},{"key":"10.1016\/j.bbrc.2021.12.051_bib9","first-page":"413","article-title":"Characterization of atrial histology in a patient with hypertrophic cardiomyopathy: Possible evidence of a primary atrial myopathy","volume":"7","author":"Keane","year":"2021","journal-title":"Heart Rhythm Case Rep"},{"key":"10.1016\/j.bbrc.2021.12.051_bib10","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cardiores.2003.09.011","article-title":"Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction","volume":"60","author":"Yamashita","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2021.12.051_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2017.06.043","article-title":"The isoforms of \u03b1-actin and myosin affect the Ca2+ regulation of the actin-myosin interaction in the heart","volume":"490","author":"Shchepkin","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.12.051_bib12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1021\/acs.biochem.6b00994","article-title":"Structural and functional effects of cardiomyopathy-causing mutations in the troponin T-binding region of cardiac tropomyosin","volume":"56","author":"Matyushenko","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2021.12.051_bib13","doi-asserted-by":"crossref","first-page":"10461","DOI":"10.1016\/S0021-9258(17)34082-6","article-title":"Functional \u03b1-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl group","volume":"269","author":"Monteiro","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.12.051_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0076-6879(82)85009-X","article-title":"Preparation of myosin and its subfragments from rabbit skeletal muscle","volume":"85 Pt B","author":"Margossian","year":"1982","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.bbrc.2021.12.051_bib15","first-page":"H1048","article-title":"Electrophoretic separation and quantitation of cardiac myosin heavy chain isoforms in eight mammalian species","volume":"274","author":"Reiser","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0076-6879(82)85020-9","article-title":"Purification of muscle actin","volume":"85 Pt B","author":"Pardee","year":"1982","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0076-6879(82)85024-6","article-title":"Preparation of troponin and its subunits","volume":"85 Pt B","author":"Potter","year":"1982","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib18","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1529\/biophysj.106.081117","article-title":"Automatic detection of single fluorophores in live cells","volume":"92","author":"Mashanov","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2021.12.051_bib19","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1152\/ajpheart.00519.2015","article-title":"Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by \u03b1- and \u03b2-myosin heavy chain isoforms","volume":"309","author":"Chandra","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fphys.2016.00443","article-title":"Dilated cardiomyopathy mutation (R134W) in mouse cardiac troponin t induces greater contractile deficits against \u03b1-myosin heavy chain than against \u03b2-myosin heavy chain","volume":"7","author":"Gollapudi","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib21","doi-asserted-by":"crossref","first-page":"28498","DOI":"10.1074\/jbc.M412281200","article-title":"Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype","volume":"280","author":"Mirza","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.12.051_bib22","doi-asserted-by":"crossref","first-page":"13487","DOI":"10.1074\/jbc.M701071200","article-title":"The effect of mutations in \u03b1-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments","volume":"282","author":"Mirza","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.12.051_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/cvr\/cvt071","article-title":"Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca2\u207a sensitivity","volume":"99","author":"Memo","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2021.12.051_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10974-013-9343-z","article-title":"A\u00a0study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium","volume":"34","author":"Bai","year":"2013","journal-title":"J.\u00a0Muscle Res. Cell Motil."},{"key":"10.1016\/j.bbrc.2021.12.051_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10974-013-9358-5","article-title":"Alpha-tropomyosin mutations in inherited cardiomyopathies","volume":"34","author":"Redwood","year":"2013","journal-title":"J.\u00a0Muscle Res. Cell Motil."},{"key":"10.1016\/j.bbrc.2021.12.051_bib26","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1073\/pnas.90.13.6270","article-title":"A\u00a0familial hypertrophic cardiomyopathy locus maps to chromosome 15q2","volume":"90","author":"Thierfelder","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2021.12.051_bib27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10974-019-09560-8","article-title":"Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels","volume":"40","author":"Kopylova","year":"2019","journal-title":"J.\u00a0Muscle Res. Cell Motil."},{"key":"10.1016\/j.bbrc.2021.12.051_bib28","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1006\/jmcc.2000.1182","article-title":"Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha-tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in\u00a0vitro motility assay","volume":"32","author":"Bing","year":"2000","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1006\/bbrc.1997.7045","article-title":"Effects of two hypertrophic cardiomyopathy mutations in \u03b1-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility","volume":"236","author":"Bing","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.12.051_bib30","doi-asserted-by":"crossref","first-page":"34343","DOI":"10.1074\/jbc.M505014200","article-title":"Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in \u03b1-tropomyosin","volume":"280","author":"Chang","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2021.12.051_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1152\/ajpheart.01341.2006","article-title":"Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis","volume":"293","author":"Jagatheesan","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib32","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1152\/ajpheart.00658.2017","article-title":"Increased thin filament activation enhances alternans in human chronic atrial fibrillation","volume":"315","author":"Zile","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pbiomolbio.2011.06.001","article-title":"Contribution of mechanical factors to arrhythmogenesis in calcium overloaded cardiomyocytes: model predictions and experiments","volume":"107","author":"Katsnelson","year":"2011","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib34","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s11538-007-9285-y","article-title":"Mathematical modeling of mechanically modulated rhythm disturbances in homogeneous and heterogeneous myocardium with attenuated activity of na+ -k+ pump","volume":"70","author":"Sulman","year":"2008","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/01.CIR.0000080896.52003.DF","article-title":"Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy","volume":"108","author":"Van Driest","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2021.12.051_bib36","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","article-title":"Regulation of contraction in striated muscle","volume":"80","author":"Gordon","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2021.12.051_bib37","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1016\/S0006-3495(00)76849-4","article-title":"Different myofilament nearest-neighbor interactions have distinctive effects on contractile behavior","volume":"78","author":"Razumova","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2021.12.051_bib38","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0022-2836(02)00855-0","article-title":"Activation of striated muscle: nearest-neighbor regulatory-unit and cross-bridge influence on myofilament kinetics","volume":"322","author":"Robinson","year":"2002","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bbrc.2021.12.051_bib39","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1016\/j.bpj.2010.09.003","article-title":"The role of thin filament cooperativity in cardiac length-dependent calcium activation","volume":"99","author":"Farman","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2021.12.051_bib40","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1038\/s41598-020-62452-7","article-title":"Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges","volume":"10","author":"Kalda","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2021.12.051_bib41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10974-017-9472-x","article-title":"Cooperativity of myosin interaction with thin filaments is enhanced by stabilizing substitutions in tropomyosin","volume":"38","author":"Shchepkin","year":"2017","journal-title":"J.\u00a0Muscle Res. Cell Motil."},{"key":"10.1016\/j.bbrc.2021.12.051_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2020.11.103","article-title":"Effects of myopathy-causing mutations R91P and R245G in the TPM3 gene on structural and functional properties of slow skeletal muscle tropomyosin","volume":"534","author":"Gonchar","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.12.051_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10517-019-04462-8","article-title":"Effect of interchain disulfide crosslinking in the tropomyosin molecule on actin-myosin interaction in the atrial myocardium","volume":"167","author":"Shchepkin","year":"2019","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.bbrc.2021.12.051_bib44","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.3390\/ijms22136941","article-title":"Electrophysiological and structural remodeling of the atria in a mouse model of troponin-i mutation linked hypertrophic cardiomyopathy: implications for atrial fibrillation","volume":"22","author":"Lim","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21016867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:41:52Z","timestamp":1762094512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21016867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":44,"alternative-id":["S0006291X21016867"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.051","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}