{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:29:40Z","timestamp":1782599380871,"version":"3.54.5"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":334,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20bm0304001h0008"],"award-info":[{"award-number":["20bm0304001h0008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19bm0304001h0007"],"award-info":[{"award-number":["19bm0304001h0007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18bm03041h0006"],"award-info":[{"award-number":["18bm03041h0006"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21bm0304001h0009"],"award-info":[{"award-number":["21bm0304001h0009"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H02688"],"award-info":[{"award-number":["16H02688"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02897"],"award-info":[{"award-number":["21H02897"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H01050"],"award-info":[{"award-number":["19H01050"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K07934"],"award-info":[{"award-number":["18K07934"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bbrc.2021.12.111","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T10:22:24Z","timestamp":1641032544000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice"],"prefix":"10.1016","volume":"592","author":[{"given":"Hiroki","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Nibe-Shirakihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Aonuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-1643","authenticated-orcid":false,"given":"Satoko","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Otsubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagaishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-8707","authenticated-orcid":false,"given":"Kiichiro","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeomi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-1258","authenticated-orcid":false,"given":"Averil","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Uo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-9177","authenticated-orcid":false,"given":"Shigeru","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2021.12.111_bib1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn's disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2021.12.111_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MIB.0000000000000989","article-title":"Zinc deficiency is associated with poor clinical outcomes in patients with inflammatory bowel disease","volume":"23","author":"Siva","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bbrc.2021.12.111_bib3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/ajcn\/56.5.933","article-title":"Selenium status in patients with Crohn's disease","volume":"56","author":"Rannem","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2021.12.111_bib4","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1021\/acs.jafc.9b02391","article-title":"Effect of long-term intake of dietary titanium dioxide nanoparticles on intestine inflammation in mice","volume":"67","author":"Mu","year":"2019","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2021.12.111_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fct.2016.04.014","article-title":"Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model","volume":"93","author":"Urrutia-Ortega","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib6","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1136\/gutjnl-2015-310297","article-title":"Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome","volume":"66","author":"Ruiz","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2021.12.111_bib7","doi-asserted-by":"crossref","first-page":"10672","DOI":"10.1038\/srep10672","article-title":"Detection of trace metallic elements in oral lichenoid contact lesions using SR-XRF, PIXE, and XAFS","volume":"5","author":"Sugiyama","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2021.12.111_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10534-014-9796-6","article-title":"Estimation of trace metal elements in oral mucosa specimens by using SR-XRF, PIXE, and XAFS","volume":"28","author":"Sugiyama","year":"2015","journal-title":"Biometals"},{"key":"10.1016\/j.bbrc.2021.12.111_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s00774-018-0975-3","article-title":"Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw (MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis","volume":"37","author":"Komiya","year":"2019","journal-title":"J.\u00a0Bone Miner. Metabol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4012\/dmj.26.268","article-title":"X-ray absorption fine structure (XAFS) analysis of titanium-implanted soft tissue","volume":"26","author":"Uo","year":"2007","journal-title":"Dent. Mater. J."},{"key":"10.1016\/j.bbrc.2021.12.111_bib11","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ni.2135","article-title":"Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis","volume":"12","author":"Hammer","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00535-004-1492-9","article-title":"MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis","volume":"40","author":"Araki","year":"2005","journal-title":"J.\u00a0Gastroenterol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib13","first-page":"4557","article-title":"A\u00a0guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib14","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1038\/s41467-020-18892-w","article-title":"Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration","volume":"11","author":"Yamaguchi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.12.111_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbrc.2021.01.023","article-title":"Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1\/p62","volume":"542","author":"Aonuma","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2021.12.111_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chom.2015.12.010","article-title":"Autophagy genes enhance murine gammaherpesvirus 68 reactivation from latency by preventing virus-induced systemic inflammation","volume":"19","author":"Park","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2021.12.111_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.taap.2016.08.029","article-title":"Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure","volume":"309","author":"Jessop","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib18","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni.3172","article-title":"The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis","volume":"16","author":"Onizawa","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib19","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1080\/15548627.2015.1055439","article-title":"TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy","volume":"11","author":"Matsuzawa","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2021.12.111_bib20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/mi.2017.104","article-title":"IFN-\u03b3-dependent epigenetic regulation instructs colitogenic monocyte\/macrophage lineage differentiation in\u00a0vivo","volume":"11","author":"Nakanishi","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbrc.2021.12.111_bib21","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1038\/ncomms6779","article-title":"Autophagy enhances NF\u03baB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity","volume":"6","author":"Kanayama","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2021.12.111_bib22","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1038\/s41467-019-09667-z","article-title":"Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis","volume":"10","author":"Slowicka","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21017629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X21017629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:29:36Z","timestamp":1777379376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X21017629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":22,"alternative-id":["S0006291X21017629"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.111","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2021.12.111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}