{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:13:37Z","timestamp":1783091617022,"version":"3.54.6"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100603"],"award-info":[{"award-number":["82100603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bbrc.2022.01.060","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T09:20:04Z","timestamp":1642324804000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine"],"prefix":"10.1016","volume":"594","author":[{"given":"Chunxia","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maohua","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-0062","authenticated-orcid":false,"given":"Luyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-5856","authenticated-orcid":false,"given":"Zuojiong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.01.060_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03602532.2017.1293683","article-title":"Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters","volume":"49","author":"Cobbina","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bbrc.2022.01.060_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3109\/00498258709043962","article-title":"The metabolism of 14C-labelled trimethylamine and its N-oxide in man","volume":"17","author":"Al-Waiz","year":"1987","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bbrc.2022.01.060_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.celrep.2017.06.053","article-title":"The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue","volume":"20","author":"Schugar","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2022.01.060_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2012.12.011","article-title":"Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation","volume":"17","author":"Bennett","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00008571-200402000-00006","article-title":"Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters","volume":"14","author":"Hernandez","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.bbrc.2022.01.060_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1389200003339135","article-title":"Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism","volume":"1","author":"Cashman","year":"2000","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pharmthera.2005.01.001","article-title":"Mammalian flavin-containing monooxygenases: structure\/function, genetic polymorphisms and role in drug metabolism","volume":"106","author":"Krueger","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2022.01.060_bib8","series-title":"Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases","author":"Thoudam","year":"2016"},{"key":"10.1016\/j.bbrc.2022.01.060_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.201110131","article-title":"The impact of the unfolded protein response on human disease","volume":"197","author":"Wang","year":"2012","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2022.01.060_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic reticulum stress in liver disease","volume":"54","author":"Malhi","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0006-2952(98)00218-4","article-title":"Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3","volume":"56","author":"Lang","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2022.01.060_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900257","article-title":"Trimethylamine N-oxide aggravates liver steatosis through modulation of bile acid metabolism and inhibition of farnesoid X receptor signaling in nonalcoholic fatty liver disease","volume":"63","author":"Tan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbrc.2022.01.060_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbrc.2016.11.017","article-title":"Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome","volume":"481","author":"Sun","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.01.060_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1194\/jlr.M051680","article-title":"Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis","volume":"56","author":"Shih","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.bbrc.2022.01.060_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bcp.2014.04.007","article-title":"The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance","volume":"90","author":"Veeravalli","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib18","doi-asserted-by":"crossref","first-page":"107401","DOI":"10.1016\/j.pharmthera.2019.107401","article-title":"The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease","volume":"203","author":"Song","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2022.01.060_bib19","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2022.01.060_bib20","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4161\/auto.26448","article-title":"HSPA8\/HSC70 chaperone protein: structure, function, and chemical targeting","volume":"9","author":"Stricher","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2022.01.060_bib21","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cmet.2019.08.021","article-title":"Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction","volume":"30","author":"Chen","year":"2019","journal-title":"Cell Metabol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22000808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22000808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:14:00Z","timestamp":1757765640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22000808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":21,"alternative-id":["S0006291X22000808"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.01.060","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.01.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}