{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:03:00Z","timestamp":1791590580412,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009666","name":"Salt Science Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974074"],"award-info":[{"award-number":["81974074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900880"],"award-info":[{"award-number":["31900880"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172654"],"award-info":[{"award-number":["82172654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.bbrc.2022.01.069","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T20:27:57Z","timestamp":1642710477000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor"],"prefix":"10.1016","volume":"595","author":[{"given":"Longying","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-6348","authenticated-orcid":false,"given":"Xueke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hudie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.01.069_bib1","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.csbj.2021.04.029","article-title":"Farnesoid X receptor (FXR): structures and ligands","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.bbrc.2022.01.069_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/hep.30661","article-title":"Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis","volume":"70","author":"Ovadia","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2022.01.069_bib3","doi-asserted-by":"crossref","first-page":"G108","DOI":"10.1152\/ajpgi.00356.2017","article-title":"FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection","volume":"317","author":"Cao","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2022.01.069_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12929-018-0475-8","article-title":"Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases","volume":"25","author":"Chen","year":"2018","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.bbrc.2022.01.069_bib5","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bbadis.2017.08.016","article-title":"Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression","volume":"1864","author":"Erice","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbrc.2022.01.069_bib6","doi-asserted-by":"crossref","first-page":"14549","DOI":"10.1111\/jcmm.16083","article-title":"Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2\/STAT3 signalling via transactivation of SOCS3 gene","volume":"24","author":"Li","year":"2020","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2022.01.069_bib7","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/s41598-017-12629-4","article-title":"The FXR agonist, obeticholic acid, suppresses HCC proliferation & metastasis: role of IL-6\/STAT3 signalling pathway","volume":"7","author":"Attia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.01.069_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10713","article-title":"Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis","volume":"7","author":"Gomez-Ospina","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2022.01.069_bib9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s40265-016-0616-x","article-title":"Obeticholic acid: first global approval","volume":"76","author":"Markham","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.bbrc.2022.01.069_bib10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/hep.30509","article-title":"The nonsteroidal farnesoid X receptor agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with primary sclerosing cholangitis","volume":"70","author":"Trauner","year":"2019","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2022.01.069_bib11","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bbrc.2022.01.069_bib12","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1016\/j.bmcl.2008.06.073","article-title":"Conformationally constrained farnesoid X receptor (FXR) agonists: naphthoic acid-based analogs of GW 4064","volume":"18","author":"Akwabi-Ameyaw","year":"2008","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.bbrc.2022.01.069_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/biomedicines9010060","article-title":"The non-steroidal FXR agonist cilofexor improves portal hypertension and reduces hepatic fibrosis in a rat NASH model","volume":"9","author":"Schwabl","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2022.01.069_bib14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/hep.31205","article-title":"Cilofexor, a nonsteroidal FXR agonist, in patients with noncirrhotic NASH: a phase 2 randomized controlled trial","volume":"72","author":"Patel","year":"2020","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2022.01.069_bib15","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1172\/JCI64551","article-title":"The TGR5 receptor mediates bile acid-induced itch and analgesia","volume":"123","author":"Alemi","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2022.01.069_bib16","first-page":"8","article-title":"MRGPRX4 is a bile acid receptor for human cholestatic itch","author":"Yu","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.bbrc.2022.01.069_bib17","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.bbrc.2020.10.039","article-title":"Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor","volume":"534","author":"Jiang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.01.069_bib18","doi-asserted-by":"crossref","first-page":"19795","DOI":"10.1074\/jbc.RA119.010730","article-title":"Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements","volume":"294","author":"Jiang","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.01.069_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s41365-018-0398-9","article-title":"Upgrade of macromolecular crystallography beamline BL17U1 at SSRF","volume":"29","author":"Wang","year":"2018","journal-title":"Nucl. Sci. Tech."},{"key":"10.1016\/j.bbrc.2022.01.069_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2022.01.069_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ymeth.2011.07.005","article-title":"The Phenix software for automated determination of macromolecular structures","volume":"55","author":"Adams","year":"2011","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.bbrc.2022.01.069_bib22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/bmb.20987","article-title":"PyMOL mControl: manipulating molecular visualization with mobile devices","volume":"45","author":"Lam","year":"2017","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.bbrc.2022.01.069_bib23","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1093\/nar\/gkz077","article-title":"Structural basis for DNA recognition by FOXC2","volume":"47","author":"Chen","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2022.01.069_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-020-2569-1","article-title":"Structural basis of GPBAR activation and bile acid recognition","volume":"587","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.01.069_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-04126-6","article-title":"Structure, function and pharmacology of human itch GPCRs","author":"Cao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.01.069_bib26","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1097-2765(03)00112-6","article-title":"Structural basis for bile acid binding and activation of the nuclear receptor FXR","volume":"11","author":"Mi","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2022.01.069_bib27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13062-020-00267-2","article-title":"AMDock: a versatile graphical tool for assisting molecular docking with Autodock Vina and Autodock4","volume":"15","author":"Vald\u00e9s-Tresanco","year":"2020","journal-title":"Biol. Direct"},{"key":"10.1016\/j.bbrc.2022.01.069_bib28","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1053\/j.gastro.2014.08.042","article-title":"The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice","volume":"147","author":"Lieu","year":"2014","journal-title":"Gastroenterology"}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2022.02.036","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22000882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22000882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:04:14Z","timestamp":1777399454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22000882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":28,"alternative-id":["S0006291X22000882"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.01.069","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.01.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}