{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:24:27Z","timestamp":1784867067271,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773709"],"award-info":[{"award-number":["81773709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bbrc.2022.01.113","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T17:37:17Z","timestamp":1643737037000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice"],"prefix":"10.1016","volume":"598","author":[{"given":"Xiaoqian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.01.113_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.schres.2011.04.007","article-title":"Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder","volume":"129","author":"Abdolmaleky","year":"2011","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbrc.2022.01.113_bib2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-020-3008-z","article-title":"A\u00a0non-hallucinogenic psychedelic analogue with therapeutic potential","volume":"589","author":"Cameron","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.01.113_bib3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/272278a0","article-title":"Effects of lisuride and LSD on cerebral monoamine systems and hallucinosis","volume":"272","author":"Pieri","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.01.113_bib4","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/npp.2009.29","article-title":"5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice","volume":"34","author":"Halberstadt","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbrc.2022.01.113_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1124\/mol.58.5.877","article-title":"Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5","volume":"58","author":"Shapiro","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.01.113_bib6","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.neuropharm.2007.03.013","article-title":"Role of G(q) protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane","volume":"52","author":"Garcia","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2022.01.113_bib7","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.cell.2020.08.024","article-title":"Structure of a hallucinogen-activated Gq-coupled 5-HT(2A) serotonin receptor","volume":"182","author":"Kim","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2022.01.113_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.bbrc.2020.08.022","article-title":"Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT(2A) receptor","volume":"531","author":"Banerjee","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.01.113_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.106.104463","article-title":"Functional selectivity and classical concepts of quantitative pharmacology","volume":"320","author":"Urban","year":"2007","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.bbrc.2022.01.113_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0091-3057(02)00845-6","article-title":"Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice","volume":"73","author":"K\u0142odzinska","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbrc.2022.01.113_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00011-016-1011-5","article-title":"G\u00a0protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis","volume":"66","author":"Shu","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2022.01.113_bib12","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1080\/14767058.2018.1542682","article-title":"The phosphodiesterase-4 inhibitor Rolipram promotes cognitive function recovery in prenatal Escherichia coli infected offspring","volume":"33","author":"Zhu","year":"2020","journal-title":"J.\u00a0Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.bbrc.2022.01.113_bib13","first-page":"3682936","article-title":"5-HT2A receptor binding in the frontal cortex of Parkinson's disease patients and alpha-synuclein overexpressing mice: a postmortem study","author":"Rasmussen","year":"2016","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.bbrc.2022.01.113_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.sbi.2020.04.008","article-title":"Structural features of activated GPCR signaling complexes","volume":"63","author":"Wang","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbrc.2022.01.113_bib15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.euroneuro.2020.06.012","article-title":"Can G(i1) biased 5-HT(2A) inverse agonists improve the treatment of psychosis?","volume":"37","author":"Juki\u0107","year":"2020","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.bbrc.2022.01.113_bib16","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.celrep.2018.05.022","article-title":"Psychedelics promote structural and functional neural plasticity","volume":"23","author":"Ly","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2022.01.113_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cellsig.2004.09.009","article-title":"cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases","volume":"17","author":"Feliciello","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2022.01.113_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.neuro.21.1.127","article-title":"CREB and memory","volume":"21","author":"Silva","year":"1998","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2022.01.113_bib19","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s11064-020-03153-5","article-title":"The chronic treatment with 5-HT(2A) receptor agonists affects the behavior and the BDNF system in mice","volume":"45","author":"Tsybko","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2022.01.113_bib20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuron.2007.01.008","article-title":"Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior","volume":"53","author":"Gonz\u00e1lez-Maeso","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2022.01.113_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-81552-6","article-title":"Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT(2A) receptor activation","volume":"11","author":"Contreras","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.01.113_bib22","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.neuropharm.2012.01.010","article-title":"Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades","volume":"62","author":"Delille","year":"2012","journal-title":"Neuropharmacology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22001516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22001516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:14:35Z","timestamp":1757765675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22001516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":22,"alternative-id":["S0006291X22001516"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.01.113","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.01.113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}