{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:20:13Z","timestamp":1791429613424,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM118277"],"award-info":[{"award-number":["R01 GM118277"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07357"],"award-info":[{"award-number":["19K07357"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bbrc.2022.02.028","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T09:20:08Z","timestamp":1644744008000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Isoflurane attenuates sepsis-associated lung injury"],"prefix":"10.1016","volume":"599","author":[{"given":"Sophia","family":"Koutsogiannaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narihito","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.02.028_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Sepsis Campaign Guidelines Committee including the Pediatric, Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbrc.2022.02.028_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1871529X15666150108114810","article-title":"Sepsis pathophysiology and anesthetic consideration","volume":"15","author":"Yuki","year":"2015","journal-title":"Cardiovasc. Haematol. Disord. - Drug Targets"},{"key":"10.1016\/j.bbrc.2022.02.028_bib3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.200805-722OC","article-title":"Has mortality from acute respiratory distress syndrome decreased over time?: a systematic review","volume":"179","author":"Phua","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbrc.2022.02.028_bib4","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/CCM.0b013e31819fefdf","article-title":"Recent trends in acute lung injury mortality: 1996-2005","volume":"37","author":"Erickson","year":"2009","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbrc.2022.02.028_bib5","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1097\/CCM.0b013e3181aee5dd","article-title":"Management of acute lung injury and acute respiratory distress syndrome in children","volume":"37","author":"Randolph","year":"2009","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbrc.2022.02.028_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.prrv.2007.03.001","article-title":"Pediatric acute lung injury","volume":"8","author":"Dahlem","year":"2007","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.bbrc.2022.02.028_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00134-004-2157-0","article-title":"Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units","volume":"30","author":"Finfer","year":"2004","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbrc.2022.02.028_bib8","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","article-title":"International study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"Vincent","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2022.02.028_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/2047-783X-15-12-525","article-title":"Treatment of complicated intra-abdominal infections in the era of multi-drug resistant bacteria","volume":"15","author":"Herzog","year":"2010","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.bbrc.2022.02.028_bib10","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0140-6736(12)61148-9","article-title":"European surgical outcomes study group for the trials groups of the European Society of intensive care, A. The European Society of, mortality after surgery in Europe: a 7 day cohort study","volume":"380","author":"Pearse","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2022.02.028_bib11","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.jss.2011.12.037","article-title":"Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation","volume":"178","author":"Bedirli","year":"2012","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.bbrc.2022.02.028_bib12","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2147\/IJN.S41625","article-title":"Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice","volume":"6","author":"Xiong","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2022.02.028_bib13","first-page":"148","article-title":"Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen","volume":"13","author":"Jung","year":"2016","journal-title":"J.\u00a0Immunot."},{"key":"10.1016\/j.bbrc.2022.02.028_bib14","first-page":"402","article-title":"From the cover: prolonged exposure to volatile anesthetic isoflurane Worsens the outcome of polymicrobial abdominal sepsis","volume":"156","author":"Koutsogiannaki","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbrc.2022.02.028_bib15","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1096\/fj.08-113324","article-title":"The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity","volume":"22","author":"Yuki","year":"2008","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2022.02.028_bib16","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1096\/fj.12-212746","article-title":"Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1","volume":"26","author":"Yuki","year":"2012","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2022.02.028_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbrc.2021.04.045","article-title":"Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung","volume":"557","author":"Yuki","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.02.028_bib18","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in\u00a0vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.02.028_bib19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1182\/blood.V99.1.336","article-title":"Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1","volume":"99","author":"Dunne","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2022.02.028_bib20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/SHK.0000000000000250","article-title":"The role of macrophage 1 antigen in polymicrobial sepsis","volume":"42","author":"Liu","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.bbrc.2022.02.028_bib21","doi-asserted-by":"crossref","first-page":"14528","DOI":"10.1096\/fj.201901570R","article-title":"Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system","volume":"33","author":"Okuno","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2022.02.028_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1189\/jlb.0703340","article-title":"Mouse bone marrow contains large numbers of functionally competent neutrophils","volume":"75","author":"Boxio","year":"2004","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2022.02.028_bib23","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.devcel.2013.06.008","article-title":"The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway","volume":"26","author":"Kamakura","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2022.02.028_bib24","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/42506","article-title":"A\u00a0G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis","volume":"387","author":"Yokomizo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.02.028_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117888","article-title":"Biochemical characterization of three BLT receptors in zebrafish","volume":"10","author":"Okuno","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.02.028_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nchembio.2547","article-title":"Na(+)-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1","volume":"14","author":"Hori","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2022.02.028_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216163","article-title":"Volatile anesthetics affect macrophage phagocytosis","volume":"14","author":"Zha","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.02.028_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1465-9921-7-125","article-title":"Role of TNFalpha in pulmonary pathophysiology","volume":"7","author":"Mukhopadhyay","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrc.2022.02.028_bib29","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jmii.2019.07.009","article-title":"Anti-IFN-gamma therapy alleviates acute lung injury induced by severe influenza A (H1N1) pdm09 infection in mice","volume":"54","author":"Liu","year":"2021","journal-title":"J.\u00a0Microbiol. Immunol. Infect."},{"key":"10.1016\/j.bbrc.2022.02.028_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1165\/rcmb.2012-0525OC","article-title":"Pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis","volume":"50","author":"Monteiro","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2022.02.028_bib31","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0005-2760(89)90264-6","article-title":"On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE","volume":"1004","author":"Serhan","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2022.02.028_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001879","article-title":"Anesthetics impact the resolution of inflammation","volume":"3","author":"Chiang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.02.028_bib33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1186\/s13075-014-0496-y","article-title":"Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis","volume":"16","author":"Dixit","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2022.02.028_bib34","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1096\/fj.201500117","article-title":"Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)","volume":"30","author":"Ichiki","year":"2016","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2022.02.028_bib35","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006049","article-title":"Signaling in innate immunity and inflammation","volume":"4","author":"Newton","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bbrc.2022.02.028_bib36","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0026-895X(24)12189-X","article-title":"G\u00a0protein-coupled receptors as direct targets of inhaled anesthetics","volume":"61","author":"Ishizawa","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.02.028_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF00455325","article-title":"15-hydroxyeicosatetraenoic acid (15-HETE) specifically inhibits the LTB4-induced skin response","volume":"281","author":"Ternowitz","year":"1989","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.bbrc.2022.02.028_bib38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22002170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22002170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:15:54Z","timestamp":1757765754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22002170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":38,"alternative-id":["S0006291X22002170"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.02.028","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoflurane attenuates sepsis-associated lung injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}