{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:55:56Z","timestamp":1758048956134,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002628","name":"Incheon National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bbrc.2022.02.042","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:20:40Z","timestamp":1644578440000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Metabolic profiling in the hypothalamus of aged mice"],"prefix":"10.1016","volume":"599","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-8513","authenticated-orcid":false,"given":"Ye Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byong Seo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuri","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-012X","authenticated-orcid":false,"given":"Thai Hien","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sewon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-5370","authenticated-orcid":false,"given":"Jae Kwang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Geun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.02.042_bib1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nrn2421","article-title":"Brain foods: the effects of nutrients on brain function","volume":"9","author":"G\u00f3mez-Pinilla","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3945\/an.117.016261","article-title":"Nutritional factors affecting adult neurogenesis and cognitive function","volume":"8","author":"Poulose","year":"2017","journal-title":"Adv. Nutrit. Int. Rev. J."},{"key":"10.1016\/j.bbrc.2022.02.042_bib3","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2174\/15672050113109990037","article-title":"Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia","volume":"10","author":"Akinyemi","year":"2013","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbrc.2022.02.042_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.02.042_bib5","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1007\/s12035-020-02023-z","article-title":"The role of neurovascular system in neurodegenerative diseases","volume":"57","author":"Ahmad","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2022.02.042_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuint.2019.01.025","article-title":"Local and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy","volume":"127","author":"Wesley","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbrc.2022.02.042_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fnagi.2017.00298","article-title":"Age drives distortion of brain metabolic, vascular and cognitive functions, and the gut microbiome","volume":"9","author":"Hoffman","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/dmm.026609","article-title":"Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity","volume":"10","author":"Timper","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbrc.2022.02.042_bib9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12020-015-0658-y","article-title":"Hypothalamic-autonomic control of energy homeostasis","volume":"50","author":"Seoane-Collazo","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.bbrc.2022.02.042_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2009.12.024","article-title":"Hypothalamic nutrient sensing in the control of energy homeostasis","volume":"209","author":"Blouet","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2022.02.042_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mad.2018.04.008","article-title":"Role of hypothalamus in aging and its underlying cellular mechanisms","volume":"177","author":"Kim","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2022.02.042_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fnmol.2018.00002","article-title":"Hypothalamic alterations in neurodegenerative diseases and their relation to abnormal energy metabolism","volume":"11","author":"Vercruysse","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib13","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.3390\/molecules25143170","article-title":"Characterization of fatty acid composition underlying hypothalamic inflammation in aged mice","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2022.02.042_bib14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e9langer","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2022.02.042_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2022.02.042_bib16","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3390\/ijms20040941","article-title":"Metabolic plasticity of astrocytes and aging of the brain","volume":"20","author":"Morita","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib17","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1007\/s00436-016-5112-4","article-title":"Determination of Ancylostoma caninum ova viability using metabolic profiling","volume":"115","author":"Gyawali","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bbrc.2022.02.042_bib18","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3390\/ijms22041587","article-title":"Adiponectin controls nutrient availability in hypothalamic astrocytes","volume":"22","author":"Song","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2021.04.043","article-title":"Enhanced lipid utilization is coupled to the sickness responses triggered by lipopolysaccharide","volume":"558","author":"Park","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.02.042_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aca.2009.11.042","article-title":"Chemometrics in metabolomics\u2014a review in human disease diagnosis","volume":"659","author":"Madsen","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bbrc.2022.02.042_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jbi.2014.12.001","article-title":"Comparative analysis of targeted metabolomics: dominance-based rough set approach versus orthogonal partial least square-discriminant analysis","volume":"53","author":"Blasco","year":"2015","journal-title":"J.\u00a0Biomed. Inf."},{"key":"10.1016\/j.bbrc.2022.02.042_bib22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jchromb.2016.08.042","article-title":"Plasma metabolic profiling analysis of cyclophosphamide-induced cardiotoxicity using metabolomics coupled with UPLC\/Q\u2fffTOF\u2fffMS and ROC curve","volume":"1033","author":"Yin","year":"2016","journal-title":"J.\u00a0Chromatogr. B"},{"key":"10.1016\/j.bbrc.2022.02.042_bib23","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1460-9568.2010.07126.x","article-title":"Age-related changes in metabolic profiles of rat hippocampus and cortices","volume":"31","author":"Paban","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib24","doi-asserted-by":"crossref","first-page":"12795","DOI":"10.1523\/JNEUROSCI.3520-09.2009","article-title":"Nutrition, brain aging, and neurodegeneration","volume":"29","author":"Joseph","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2022.02.042_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(00)00225-6","article-title":"Glutamatergic neurotransmission in aging: a critical perspective","volume":"122","author":"Segovia","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2022.02.042_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.mad.2011.04.012","article-title":"Study of DNA damage via the comet assay and base excision repair activities in rat brain neurons and astrocytes during aging","volume":"132","author":"Swain","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2022.02.042_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj2814","article-title":"Astrocytic lipid metabolism determines susceptibility to diet-induced obesity","volume":"7","author":"Varela","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2022.02.042_bib28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2016.07.028","article-title":"Astrocytic insulin signaling couples brain glucose uptake with nutrient availability","volume":"166","author":"Garcia-Caceres","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2022.02.042_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01846-w","article-title":"Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation","volume":"17","author":"Jin","year":"2020","journal-title":"J.\u00a0Neuroinflammation"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22002315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22002315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:16:06Z","timestamp":1757765766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22002315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":29,"alternative-id":["S0006291X22002315"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.02.042","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic profiling in the hypothalamus of aged mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.02.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}