{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:40:25Z","timestamp":1791578425192,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.bbrc.2022.03.001","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:53:13Z","timestamp":1646218393000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["SIRT3 improves bone regeneration and rescues diabetic fracture healing by regulating oxidative stress"],"prefix":"10.1016","volume":"604","author":[{"given":"Xiaowen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhen","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.03.001_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11914-015-0286-8","article-title":"Diabetes and its effect on bone and fracture healing","volume":"13","author":"Jiao","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbrc.2022.03.001_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s11914-015-0260-5","article-title":"Diabetes, diabetic complications, and fracture risk","volume":"13","author":"Oei","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbrc.2022.03.001_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11914-014-0202-7","article-title":"Diabetes, collagen, and bone quality","volume":"12","author":"Saito","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbrc.2022.03.001_bib4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1600-0501.2010.01923.x","article-title":"The effect of diabetes mellitus on osseous healing: the effect of diabetes mellitus on osseous healing","volume":"21","author":"Retzepi","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.bbrc.2022.03.001_bib5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"On behalf of the IOF Bone and Diabetes Working Group","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2022.03.001_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00011-010-0246-9","article-title":"Inflammation as death or life signal in diabetic fracture healing","volume":"60","author":"R\u0151szer","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2022.03.001_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/17453674.2012.747054","article-title":"Patient-related risk factors for fracture-healing complications in the United Kingdom general practice research database","volume":"83","author":"Hernandez","year":"2012","journal-title":"Acta Orthop."},{"key":"10.1016\/j.bbrc.2022.03.001_bib8","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.bone.2009.02.004","article-title":"Role of oxidative stress in diabetic bone disorder","volume":"45","author":"Hamada","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2022.03.001_bib9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"CIA"},{"key":"10.1016\/j.bbrc.2022.03.001_bib10","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2022.03.001_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00223-010-9393-9","article-title":"Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures","volume":"87","author":"Baek","year":"2010","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2022.03.001_bib12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41419-018-1057-0","article-title":"SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis","volume":"9","author":"Srivastava","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2022.03.001_bib13","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.bbadis.2016.10.021","article-title":"Sirt3 deficiency exacerbates diabetic cardiac dysfunction: role of Foxo3A-Parkin-mediated mitophagy","volume":"1863","author":"Yu","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbrc.2022.03.001_bib14","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.1002\/jcb.28033","article-title":"Targeting anti-aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis","volume":"120","author":"Shaikh","year":"2019","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2022.03.001_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/cdd.2017.144","article-title":"SIRT3\/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress","volume":"25","author":"Gao","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2022.03.001_bib16","doi-asserted-by":"crossref","first-page":"116061","DOI":"10.1016\/j.bone.2021.116061","article-title":"Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice","volume":"151","author":"Zhang","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2022.03.001_bib17","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00125-017-4269-4","article-title":"Diabetes, bone and glucose-lowering agents: basic biology","volume":"60","author":"Lecka-Czernik","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2022.03.001_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2013.00130","article-title":"Neuro-modulating effects of Honokiol: a review","volume":"4","author":"Woodbury","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbrc.2022.03.001_bib19","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1089\/ars.2009.2440","article-title":"Honokiol, a multifunctional antiangiogenic and antitumor agent","volume":"11","author":"Fried","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2022.03.001_bib20","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1038\/ncomms7656","article-title":"Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3","volume":"6","author":"Pillai","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2022.03.001_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2022.03.001_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00223-019-00576-3","article-title":"Role of Nrf2 in fracture healing: clinical aspects of oxidative stress","volume":"105","author":"Kubo","year":"2019","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2022.03.001_bib23","first-page":"1","article-title":"Mesenchymal stem cells attenuate diabetic lung fibrosis via adjusting Sirt3-mediated stress responses in rats","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2022.03.001_bib24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2022.03.001_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6354787","article-title":"Molecular modulation of osteoblasts and osteoclasts in type 2 diabetes","volume":"2018","author":"Rathinavelu","year":"2018","journal-title":"J.\u00a0Diabetes Res."},{"key":"10.1016\/j.bbrc.2022.03.001_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jbmr.2974","article-title":"SOD2 and Sirt3 control osteoclastogenesis by regulating mitochondrial ROS: role OF SOD2 and SIRT3 IN osteoclastogenesis","volume":"32","author":"Kim","year":"2017","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2022.03.001_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20120030","article-title":"SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging","volume":"444","author":"Giralt","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2022.03.001_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2019.01.035","article-title":"NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia","volume":"142","author":"Ward","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2022.03.001_bib29","first-page":"1","article-title":"Melatonin increases bone mass around the prostheses of OVX rats by ameliorating mitochondrial oxidative stress via the SIRT3\/SOD2 signaling pathway","volume":"2019","author":"Zhou","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2022.03.001_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146728","article-title":"Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency","volume":"6","author":"Ling","year":"2021","journal-title":"JCI Insight"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22003205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22003205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:16:29Z","timestamp":1757765789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22003205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":30,"alternative-id":["S0006291X22003205"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.03.001","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT3 improves bone regeneration and rescues diabetic fracture healing by regulating oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}