{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:57:01Z","timestamp":1758049021102,"version":"3.44.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bbrc.2022.04.030","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T20:53:42Z","timestamp":1649710422000},"page":"77-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats"],"prefix":"10.1016","volume":"610","author":[{"given":"Yasuhiro","family":"Shibata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Kumamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-925X","authenticated-orcid":false,"given":"Shinya","family":"Ugawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.04.030_bib1","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.3390\/ijms22094810","article-title":"Acid-sensing ion channels and mechanosensation","volume":"22","author":"Ruan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.04.030_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/febs.13840","article-title":"ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters","volume":"284","author":"Israel","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2022.04.030_bib3","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1074\/jbc.271.18.10433","article-title":"The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans","volume":"271","author":"Waldmann","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.04.030_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/35039512","article-title":"The mammalian sodium channel BNC1 is required for normal touch sensation","volume":"407","author":"Price","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.04.030_bib5","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1074\/jbc.M104748200","article-title":"The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons","volume":"277","author":"Duggan","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.04.030_bib6","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1073\/pnas.94.4.1459","article-title":"BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels","volume":"94","author":"Garc\u00eda-A\u00f1overos","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2022.04.030_bib7","doi-asserted-by":"crossref","first-page":"28819","DOI":"10.1074\/jbc.272.46.28819","article-title":"The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties","volume":"272","author":"Bassilana","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.04.030_bib8","doi-asserted-by":"crossref","first-page":"18296","DOI":"10.1074\/jbc.M312145200","article-title":"Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons","volume":"279","author":"Askwith","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.04.030_bib9","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.cgt.7700249","article-title":"A\u00a0novel strategy for cancer therapy by mutated mammalian degenerin gene transfer","volume":"7","author":"Horimoto","year":"2000","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bbrc.2022.04.030_bib10","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/mt.2009.33","article-title":"Mutant sodium channel for tumor therapy","volume":"17","author":"Tannous","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2022.04.030_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/345410a0","article-title":"The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans","volume":"345","author":"Chalfie","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.04.030_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/349588a0","article-title":"The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration","volume":"349","author":"Driscoll","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.04.030_bib13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/367467a0","article-title":"Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans","volume":"367","author":"Huang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.04.030_bib14","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1073\/pnas.0810599106","article-title":"A\u00a0point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice","volume":"106","author":"Becker","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2022.04.030_bib15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/jnc.14002","article-title":"Mechanisms of neuronal migration in the adult brain","volume":"141","author":"Kaneko","year":"2017","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2022.04.030_bib16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/00207454.2018.1545771","article-title":"Neurogenesis in the adult hippocampus: history, regulation, and prospective roles","volume":"129","author":"Fares","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.bbrc.2022.04.030_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41583-018-0002-7","article-title":"The basal ganglia and the cerebellum: nodes in an integrated network","volume":"19","author":"Bostan","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2022.04.030_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2018.06.055","article-title":"The cerebellum as a movement sensor","volume":"688","author":"Therrien","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2022.04.030_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/14734220601187741","article-title":"Mechanisms of cerebellar gait ataxia","volume":"6","author":"Morton","year":"2007","journal-title":"Cerebellum"},{"key":"10.1016\/j.bbrc.2022.04.030_bib20","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1152\/jn.00378.2006","article-title":"Acid-sensing ionic channels in the rat vestibular end organs and ganglia","volume":"96","author":"Mercado","year":"2006","journal-title":"J.\u00a0Neurophysiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22005538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22005538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:17:17Z","timestamp":1757765837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22005538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":20,"alternative-id":["S0006291X22005538"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.04.030","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}