{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:45:53Z","timestamp":1770461153070,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773710"],"award-info":[{"award-number":["81773710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030112"],"award-info":[{"award-number":["82030112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1468200"],"award-info":[{"award-number":["20ZR1468200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbrc.2022.04.083","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T03:43:10Z","timestamp":1651808590000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Antinociceptive activities and mechanism of action of Cepharanthine"],"prefix":"10.1016","volume":"614","author":[{"given":"Xiang-Yan","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dong","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Rui","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Gen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.04.083_bib1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3389\/fpsyg.2017.00664","article-title":"Chronic pain as a hypothetical construct: a practical and philosophical consideration","volume":"8","author":"Doleys","year":"2017","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib2","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s12264-020-00515-5","article-title":"Mu-Opioid receptors expressed in Glutamatergic neurons are essential for morphine withdrawal","volume":"36","author":"Zhang","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbrc.2022.04.083_bib3","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.14309\/ajg.0000000000001384","article-title":"Considerations of comorbidity and codes related to opioid prescriptions for gastrointestinal diseases","volume":"116","author":"Liu","year":"2021","journal-title":"Off. J. Am. College Gastroenterol. ACG"},{"key":"10.1016\/j.bbrc.2022.04.083_bib4","article-title":"Strategies towards safer opioid analgesics-a review of old and upcoming targets","author":"Varga","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108673","article-title":"A\u00a0promising chemical series of positive allosteric modulators of the \u03bc-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects","volume":"195","author":"Pryce","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2022.04.083_bib6","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3389\/fphys.2019.01407","article-title":"Presynaptic mechanisms and KCNQ potassium channels modulate opioid depression of respiratory drive","volume":"10","author":"Wei","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s40264-018-0660-4","article-title":"Comparative rates of mortality and serious adverse effects among commonly prescribed opioid analgesics","volume":"41","author":"Murphy","year":"2018","journal-title":"Drug Saf."},{"key":"10.1016\/j.bbrc.2022.04.083_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1734-1140(11)70500-X","article-title":"Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions","volume":"63","author":"Rogosnitzky","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbrc.2022.04.083_bib9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cyto.2015.09.008","article-title":"Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock\/resuscitation in rats","volume":"76","author":"Kao","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.bbrc.2022.04.083_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jep.2014.04.024","article-title":"Ethnobotany, phytochemistry and pharmacology of Stephania rotunda Lour","volume":"154","author":"Desgrouas","year":"2014","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0006-2952(01)00692-X","article-title":"Suppression of cytokine production and neural cell death by the anti-inflammatory alkaloid cepharanthine: a potential agent against HIV-1 encephalopathy","volume":"62","author":"Okamoto","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152956","article-title":"Cepharanthine: an update of its mode of action, pharmacological properties and medical applications","volume":"62","author":"Bailly","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2022.04.083_bib13","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3390\/biom9110696","article-title":"Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC-5 human lung cells","volume":"9","author":"Kim","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbrc.2022.04.083_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105143","article-title":"Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING\/TBK1\/P62 pathway","volume":"193","author":"Liu","year":"2021","journal-title":"Antivir. Res."},{"key":"10.1016\/j.bbrc.2022.04.083_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.canlet.2017.09.009","article-title":"Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth","volume":"409","author":"Lyu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2022.04.083_bib16","first-page":"1","article-title":"A\u00a0case of improvement of clozapine-induced low leukocyte counts by adenine, cepharanthin and ninjin-yoei-to in a patient with treatment-resistant schizophrenia","volume":"7","author":"Kamei","year":"2021","journal-title":"J.\u00a0Pharm. Healthc. Sci."},{"key":"10.1016\/j.bbrc.2022.04.083_bib17","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.intimp.2012.04.015","article-title":"Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma","volume":"13","author":"Tabata","year":"2012","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2022.04.083_bib18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.lfs.2006.12.001","article-title":"The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases","volume":"80","author":"Furusawa","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2022.04.083_bib19","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/bib\/bbaa387","article-title":"Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus","volume":"22","author":"Li","year":"2021","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.bbrc.2022.04.083_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102367","article-title":"Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment","volume":"24","author":"Ohashi","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.bbrc.2022.04.083_bib21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2008.02.028","article-title":"LPK-26, a novel \u03ba-opioid receptor agonist with potent antinociceptive effects and low dependence potential","volume":"584","author":"Tao","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/aps.2014.145","article-title":"Novel \u03ba-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation","volume":"36","author":"Zhang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2022.04.083_bib23","first-page":"1","article-title":"Pharmacological characterization of dezocine, a potent analgesic acting as a \u03ba partial agonist and \u03bc partial agonist","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.04.083_bib24","article-title":"Antidiarrhoeal properties of Syzygium guineense leaf extract and identification of chemical constituents in its active column fractions","volume":"16","author":"Ezenyi","year":"2019","journal-title":"J.\u00a0Compl. Integr. Med."},{"key":"10.1016\/j.bbrc.2022.04.083_bib25","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s43440-020-00132-z","article-title":"Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19","volume":"72","author":"Rogosnitzky","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbrc.2022.04.083_bib26","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1017\/erm.2012.5","article-title":"Opioid receptor heteromers in analgesia","volume":"14","author":"Costantino","year":"2012","journal-title":"Expet Rev. Mol. Med."},{"key":"10.1016\/j.bbrc.2022.04.083_bib27","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00204-021-03068-2","article-title":"Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity","volume":"95","author":"Baldo","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrc.2022.04.083_bib28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s43440-021-00251-1","article-title":"Influence of G protein-biased agonists of \u03bc-opioid receptor on addiction-related behaviors","volume":"73","author":"Kudla","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbrc.2022.04.083_bib29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2147\/DDDT.S221278","article-title":"The use of peripheral \u03bc-opioid receptor antagonists (PAMORA) in the management of opioid-induced constipation: an update on their efficacy and safety","volume":"14","author":"Pergolizzi","year":"2020","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22006180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22006180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:19:29Z","timestamp":1757765969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22006180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":29,"alternative-id":["S0006291X22006180"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.04.083","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive activities and mechanism of action of Cepharanthine","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.04.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}