{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:18:24Z","timestamp":1791695904284,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbrc.2022.05.025","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T03:03:09Z","timestamp":1652238189000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["LXR activation ameliorates high glucose stress-induced aberrant mitochondrial dynamics via downregulation of Calpain1 expression in H9c2 cardiomyoblasts"],"prefix":"10.1016","volume":"614","author":[{"given":"Jiejin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengdan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-1581","authenticated-orcid":false,"given":"Ge","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-350X","authenticated-orcid":false,"given":"Qing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.05.025_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/CIRCRESAHA.118.311371","article-title":"Heart failure in type 2 diabetes mellitus","volume":"124","author":"Kenny","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2022.05.025_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-018-0711-0","article-title":"Of mice and men: models and mechanisms of diabetic cardiomyopathy","volume":"114","author":"Riehle","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib3","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2022.05.025_bib4","first-page":"637","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications, Redox","volume":"11","author":"Rovira-Llopis","year":"2017","journal-title":"Biol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib5","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00011-012-0529-4","article-title":"Liver X receptor activation attenuates plaque formation and improves vasomotor function of the aortic artery in atherosclerotic ApoE(-\/-) mice","volume":"61","author":"Chen","year":"2012","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2022.05.025_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00395-012-0323-z","article-title":"Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury","volume":"108","author":"Lei","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib7","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s10753-010-9281-5","article-title":"Elevated expression of liver X receptor alpha (LXR\u03b1) in myocardium of streptozotocin-induced diabetic rats","volume":"34","author":"Cheng","year":"2011","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2022.05.025_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/cvr\/cvp180","article-title":"Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling","volume":"84","author":"Wu","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2022.05.025_bib9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.acthis.2013.07.007","article-title":"Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes","volume":"116","author":"Cheng","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bbrc.2022.05.025_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12933-014-0149-0","article-title":"Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db\/db mice","volume":"13","author":"He","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib11","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bbrc.2018.07.050","article-title":"Differential effects of and mechanisms underlying the protection of cardiomyocytes by liver-X-receptor subtypes against high glucose stress-induced injury","volume":"503","author":"He","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.05.025_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2337\/db15-0963","article-title":"Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy","volume":"65","author":"Ni","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2022.05.025_bib13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1074\/jbc.M114.617167","article-title":"MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons","volume":"290","author":"Wang","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.05.025_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mito.2016.07.009","volume":"30","author":"Tangmansakulchai","year":"2016","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbrc.2022.05.025_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1750-3639.2011.00517.x","article-title":"Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells","volume":"22","author":"ElAli","year":"2012","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib16","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/eurheartj\/ehs011","article-title":"Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia\/reperfusion injury","volume":"34","author":"Pu","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2022.05.025_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/cells8030263","article-title":"Inhibition of mitochondrial complex function-the hepatotoxicity mechanism of emodin based on quantitative proteomic analyses","volume":"8","author":"Lin","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2022.05.025_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2019.09.033","article-title":"Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing","volume":"145","author":"Wang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2022.05.025_bib19","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1074\/jbc.RA118.002066","article-title":"Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function","volume":"293","author":"Suarez","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.05.025_bib20","first-page":"637","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications, Redox","volume":"11","author":"Rovira-Llopis","year":"2017","journal-title":"Biol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib21","doi-asserted-by":"crossref","first-page":"C190","DOI":"10.1152\/ajpcell.00298.2016","article-title":"Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy","volume":"312","author":"Jarosz","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.redox.2017.12.019","article-title":"Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission","volume":"15","author":"Zhou","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2337\/db16-0915","article-title":"Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of drp1-mediated mitochondrial fission","volume":"66","author":"Wang","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2022.05.025_bib24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/CIRCULATIONAHA.113.008476","article-title":"Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients","volume":"130","author":"Montaigne","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2022.05.025_bib25","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.7150\/thno.33684","article-title":"Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy","volume":"9","author":"Hu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2022.05.025_bib26","first-page":"e13428","article-title":"Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way","author":"Ding","year":"2019","journal-title":"Acta Physiol."},{"key":"10.1016\/j.bbrc.2022.05.025_bib27","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/CIRCHEARTFAILURE.114.001260","article-title":"Activation of liver-X-receptor alpha but not liver-X-receptor beta protects against myocardial ischemia\/reperfusion injury","volume":"7","author":"He","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.bbrc.2022.05.025_bib28","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/CIRCRESAHA.118.314607","article-title":"Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy","volume":"124","author":"Tong","year":"2019","journal-title":"Circ. Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22007215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22007215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:18:47Z","timestamp":1757765927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22007215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":28,"alternative-id":["S0006291X22007215"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.05.025","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LXR activation ameliorates high glucose stress-induced aberrant mitochondrial dynamics via downregulation of Calpain1 expression in H9c2 cardiomyoblasts","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}