{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:26:21Z","timestamp":1769275581642,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014424","name":"Meiji University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bbrc.2022.07.110","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T01:43:00Z","timestamp":1660009380000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells"],"prefix":"10.1016","volume":"626","author":[{"given":"Masahito","family":"Deai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rin","family":"Oya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naosi","family":"Saso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Tachihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miku","family":"Otsugu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Mine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-4014","authenticated-orcid":false,"given":"Koichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-9772","authenticated-orcid":false,"given":"Hideaki","family":"Tomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.07.110_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0022-3476(05)80750-4","article-title":"Need for the lead mobilization test in children with lead poisoning","volume":"119","author":"Markowitz","year":"1991","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.bbrc.2022.07.110_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11886-015-0690-9","article-title":"Edetate disodium-based treatment for secondary prevention in post-myocardial infarction patients","volume":"18","author":"Lamas","year":"2016","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.bbrc.2022.07.110_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051019","article-title":"EDTA chelation therapy for the treatment of neurotoxicity","volume":"20","author":"Fulgenzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.07.110_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tvjl.2003.09.009","article-title":"The effects of different anticoagulants on routine canine plasma biochemistry","volume":"167","author":"Ceron","year":"2004","journal-title":"Vet. J."},{"key":"10.1016\/j.bbrc.2022.07.110_bib5","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1073\/pnas.0409415102","article-title":"Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells","volume":"102","author":"Radu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbrc.2022.07.110_bib6","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.1074\/jbc.M407832200","article-title":"Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor","volume":"280","author":"Ishii","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.07.110_bib7","doi-asserted-by":"crossref","first-page":"45626","DOI":"10.1074\/jbc.M406966200","article-title":"TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor","volume":"279","author":"Wang","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.07.110_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature01905","article-title":"Proton-sensing G-protein-coupled receptors","volume":"425","author":"Ludwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.07.110_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030559","article-title":"GPR68: an emerging drug target in cancer","volume":"20","author":"Wiley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.07.110_bib10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/MCB.26.2.668-677.2006","article-title":"Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor","volume":"26","author":"Radu","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2022.07.110_bib11","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.4049\/jimmunol.0803466","article-title":"Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages","volume":"182","author":"Mogi","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2022.07.110_bib12","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41590-018-0226-8","article-title":"Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages","volume":"19","author":"Bohn","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2022.07.110_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2012.03.007","article-title":"Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in\u00a0vitro","volume":"683","author":"Onozawa","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.07.110_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/ecco-jcc\/jjy152","article-title":"Lack of the pH-sensing receptor TDAG8 [GPR65] in macrophages plays a detrimental role in murine models of inflammatory bowel disease","volume":"13","author":"Tcymbarevich","year":"2019","journal-title":"J.\u00a0Crohns Colitis"},{"key":"10.1016\/j.bbrc.2022.07.110_bib15","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1182\/blood-2009-05-220681","article-title":"Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner","volume":"114","author":"Kottyan","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2022.07.110_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079985","article-title":"Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model","volume":"8","author":"Aoki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.07.110_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/onc.2012.566","article-title":"Role of OGR1 in myeloid-derived cells in prostate cancer","volume":"33","author":"Yan","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2022.07.110_bib18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3109\/10799893.2015.1015736","article-title":"Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists","volume":"35","author":"Abe-Ohya","year":"2015","journal-title":"J.\u00a0Recept. Signal Transduct. Res."},{"key":"10.1016\/j.bbrc.2022.07.110_bib19","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.cellsig.2007.03.009","article-title":"Previously postulated \"ligand-independent\" signaling of GPR4 is mediated through proton-sensing mechanisms","volume":"19","author":"Tobo","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2022.07.110_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.phrs.2010.02.013","article-title":"Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways","volume":"61","author":"Liu","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2022.07.110_bib21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1262\/jrd.2018-153","article-title":"Increased luminescence of the GloSensor cAMP assay in LbetaT2 cells does not correlate with cAMP accumulation under low pH conditions","volume":"65","author":"Musha","year":"2019","journal-title":"J.\u00a0Reprod. Dev."},{"key":"10.1016\/j.bbrc.2022.07.110_bib22","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1021\/acs.biochem.0c00576","article-title":"Differential roles of extracellular histidine residues of GPR68 for proton-sensing and allosteric modulation by divalent metal ions","volume":"59","author":"Huang","year":"2020","journal-title":"Biochemistry"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22010968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22010968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:42:47Z","timestamp":1762094567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22010968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":22,"alternative-id":["S0006291X22010968"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.07.110","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.07.110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}