{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:41:08Z","timestamp":1790653268561,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","award":["C57BL\/6"],"award-info":[{"award-number":["C57BL\/6"]}],"id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bbrc.2022.08.033","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T10:10:36Z","timestamp":1660558236000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12\/TREM2 pathway"],"prefix":"10.1016","volume":"627","author":[{"given":"Rui","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.08.033_bib1","article-title":"The biology of normal bone remodelling","volume":"26","author":"Katsimbri","year":"2017","journal-title":"Eur. J. Cancer Care"},{"key":"10.1016\/j.bbrc.2022.08.033_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cyto.2018.06.013","article-title":"From macrophage to osteoclast \u2013 how metabolism determines function and activity","volume":"112","author":"Kubatzky","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.bbrc.2022.08.033_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21176001","article-title":"Learning from monocyte-macrophage fusion and multinucleation: potential therapeutic targets for osteoporosis and rheumatoid arthritis","volume":"21","author":"Gambari","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3389\/fimmu.2019.01408","article-title":"Immune function and diversity of osteoclasts in normal and pathological conditions","volume":"10","author":"Madel","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib5","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1210\/jc.2012-4113","article-title":"Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity","volume":"98","author":"Sowers","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2022.08.033_bib6","article-title":"Estrogen and bones after menopause: a reappraisal of data and future perspectives","volume":"2020","author":"Anagnostis","year":"2020","journal-title":"Hormones (Basel)"},{"key":"10.1016\/j.bbrc.2022.08.033_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11914-019-00549-3","article-title":"Update on menopausal hormone therapy for fracture prevention","volume":"17","author":"Stepan","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbrc.2022.08.033_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21207623","article-title":"Molecular mechanisms and emerging therapeutics for osteoporosis","volume":"21","author":"Noh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/MED.0000000000000507","article-title":"Combination therapies in the treatment of osteoporosis","volume":"26","author":"Kelly","year":"2019","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.bbrc.2022.08.033_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1196\/annals.1346.014","article-title":"M-CSF, c-Fms, and signaling in osteoclasts and their precursors","volume":"1068","author":"Ross","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib11","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol. Cell."},{"key":"10.1016\/j.bbrc.2022.08.033_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00774-020-01191-1","article-title":"RANKL as the master regulator of osteoclast differentiation","volume":"39","author":"Takayanagi","year":"2021","journal-title":"J.\u00a0Bone Miner. Metabol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172550","article-title":"Glycyrrhizic acid suppresses osteoclast differentiation and postmenopausal osteoporosis by modulating the NF-\u03baB, ERK, and JNK signaling pathways","volume":"859","author":"Yin","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib14","article-title":"Role of sirtuins in bone biology: potential implications for novel therapeutic strategies for osteoporosis","volume":"2021","author":"Li","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2022.08.033_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22020625","article-title":"Mechanisms of bone fragility: from osteogenesis imperfecta to secondary osteoporosis","volume":"22","author":"El-Gazzar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib16","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3390\/ijms19040984","article-title":"The sealing zone in osteoclasts: a self-organized structure on the bone","volume":"19","author":"Takito","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.scr.2015.06.009","article-title":"Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells","volume":"15","author":"Chen","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbrc.2022.08.033_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bonr.2015.10.003","article-title":"Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement","volume":"3","author":"Kim","year":"2015","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.bbrc.2022.08.033_bib19","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s40520-015-0509-y","article-title":"Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling","volume":"28","author":"Ma","year":"2016","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.bbrc.2022.08.033_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065297","article-title":"DAP12 overexpression induces osteopenia and impaired early hematopoiesis","volume":"8","author":"Despars","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.08.033_bib21","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.humimm.2013.02.003","article-title":"Structure, expression pattern and biological activity of molecular complex TREM-2\/DAP12","volume":"74","author":"Paradowska-Gorycka","year":"2013","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1359\/JBMR.051016","article-title":"TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function","volume":"21","author":"Humphrey","year":"2006","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2022.08.033_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20030027","article-title":"DAP12\/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features","volume":"198","author":"Paloneva","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2022.08.033_bib24","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1002\/jbmr.3205","article-title":"DOK3 modulates bone remodeling by negatively regulating osteoclastogenesis and positively regulating osteoblastogenesis","volume":"32","author":"Cai","year":"2017","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2022.08.033_bib25","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ajhg.2011.09.001","article-title":"Mutations in CSTA, encoding cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion","volume":"89","author":"Blaydon","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2022.08.033_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110701","article-title":"Interplay of ER\u03b1 binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells","volume":"504","author":"John Mary","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0361-9230(94)90071-X","article-title":"Cystatin a-like immunoreactivity is widely distributed in human brain and accumulates in neuritic plaques of alzheimer disease subjects","volume":"33","author":"Bernstein","year":"1994","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2022.08.033_bib28","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.7150\/ijbs.41867","article-title":"F2r negatively regulates osteoclastogenesis through inhibiting the AKT and NF\u039aB signaling pathways","volume":"16","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib29","doi-asserted-by":"crossref","first-page":"ra31","DOI":"10.1126\/scisignal.2005835","article-title":"DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis","volume":"8","author":"Zhang","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrc.2022.08.033_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110494","article-title":"Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt\/GSK3\u03b2\/NFATc1 signalling pathway","volume":"494","author":"Lin","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib31","first-page":"666","article-title":"Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation","volume":"123","author":"Lotinun","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2022.08.033_bib32","first-page":"154","article-title":"Economic burden of osteoporosis in the world: a systematic review","volume":"34","author":"Rashki Kemmak","year":"2020","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"10.1016\/j.bbrc.2022.08.033_bib33","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/jcm10030530","article-title":"Testosterone and bone health in men: a narrative review","volume":"10","author":"Shigehara","year":"2021","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.bbrc.2022.08.033_bib34","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-020-00798-w","article-title":"Bariatric surgery and osteoporosis","author":"Paccou","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2022.08.033_bib35","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1586\/17512433.2015.1099432","article-title":"The safety and tolerability profile of therapies for the prevention and treatment of osteoporosis in postmenopausal women","volume":"8","author":"Komm","year":"2015","journal-title":"Expet Rev. Clin. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib36","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.omtm.2020.04.010","article-title":"Bone-targeting AAV-mediated gene silencing in osteoclasts for osteoporosis therapy","volume":"17","author":"Yang","year":"2020","journal-title":"Mol Ther - Methods Clin Dev"},{"key":"10.1016\/j.bbrc.2022.08.033_bib37","article-title":"A\u00a0reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region","author":"Ibach","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.bbrc.2022.08.033_bib38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12016-015-8521-8","article-title":"A\u00a0comprehensive review of immunoreceptor regulation of osteoclasts","volume":"51","author":"Humphrey","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib39","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2022.08.033_bib40","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.20022220","article-title":"Impaired differentiation of osteoclasts in TREM-2-deficient individuals","volume":"198","author":"Cella","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2022.08.033_bib41","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnagi.2017.00204","article-title":"TREM2\/DAP12 complex regulates inflammatory responses in microglia via the JNK signaling pathway","volume":"9","author":"Zhong","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbrc.2022.08.033_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainresbull.2020.10.006","article-title":"Mechanism of TREM2\/DAP12 complex affecting \u03b2-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response","volume":"166","author":"Cui","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2022.08.033_bib43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1600-0765.1997.tb00935.x","article-title":"Cystatin A in gingival crevicular fluid of periodontal patients","volume":"32","author":"Blankenvoorde","year":"1997","journal-title":"J.\u00a0Periodontal. Res."},{"key":"10.1016\/j.bbrc.2022.08.033_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101849","article-title":"Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment","volume":"40","author":"Weng","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2022.08.033_bib45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.2009.00821.x","article-title":"Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation","volume":"231","author":"Negishi-Koga","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2022.08.033_bib46","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1073\/pnas.0401602101","article-title":"The immunomodulatory adapter proteins DAP12 and Fc receptor \u03b3-chain (FcR\u03b3) regulate development of functional osteoclasts through the Syk tyrosine kinase","volume":"101","author":"M\u00f3csai","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22011524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22011524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:14:18Z","timestamp":1777392858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22011524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":46,"alternative-id":["S0006291X22011524"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.08.033","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12\/TREM2 pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}