{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:24:20Z","timestamp":1760711060490,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bbrc.2022.08.035","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T10:10:36Z","timestamp":1660558236000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage"],"prefix":"10.1016","volume":"626","author":[{"given":"Dan","family":"Stratton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-1945","authenticated-orcid":false,"given":"Memory","family":"Malibha-Pinchbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-0363","authenticated-orcid":false,"given":"Jameel","family":"Inal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.08.035_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bbrc.2022.08.035_bib2","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1021\/cr900208x","article-title":"Introduction to cancer chemotherapeutics","volume":"109","author":"Shewach","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbrc.2022.08.035_bib3","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1158\/1078-0432.CCR-16-3083","article-title":"Clinically relevant concentrations of anticancer drugs: a guide for nonclinical studies","volume":"14","author":"Liston","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2022.08.035_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/B978-0-12-416020-0.00012-7","article-title":"Nanoparticles in cancer chemotherapy","volume":"104","author":"Banerjee","year":"2011","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.bbrc.2022.08.035_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3892\/ijo.2018.4661","article-title":"From chemotherapy to biological therapy: a review of novel concepts to reduce the side effects of systemic cancer treatment (Review)","volume":"54","author":"Schirrmacher","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2022.08.035_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117060","article-title":"Understanding the biology and advent of physics of cancer with perspicacity in current treatment therapy","volume":"239","author":"Korgaonkar","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2022.08.035_bib7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bbrc.2012.12.012","article-title":"Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells","volume":"430","author":"Stratton","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.08.035_bib8","article-title":"Acceleration of DNA melting kinetics using alternating electric fields","volume":"149","author":"Sensale","year":"2018","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.bbrc.2022.08.035_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1107\/S0108768109008271","article-title":"Charge density and electrostatic potential analyses in paracetamol","volume":"65","author":"Bouhmaida","year":"2009","journal-title":"Acta Crystallogr. B"},{"key":"10.1016\/j.bbrc.2022.08.035_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13628-014-0016-0","article-title":"Vesicle biomechanics in a time-varying magnetic field","volume":"8","author":"Ye","year":"2015","journal-title":"BMC Biophys."},{"key":"10.1016\/j.bbrc.2022.08.035_bib11","article-title":"Electromagnetic-field effects on structure and dynamics of amyloidogenic peptides","volume":"144","author":"Todorova","year":"2016","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.bbrc.2022.08.035_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/15368370701878820","article-title":"Protein and DNA reactions stimulated by electromagnetic fields","volume":"27","author":"Blank","year":"2008","journal-title":"Electromagn. Biol. Med."},{"key":"10.1016\/j.bbrc.2022.08.035_bib13","first-page":"817","article-title":"Effects of exposure of CHO-K1 cells to a 10-T static magnetic field","volume":"3","author":"Nakahara","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.bbrc.2022.08.035_bib14","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1096\/fj.04-3549fje","article-title":"Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells","volume":"12","author":"Nikolova","year":"2005","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2022.08.035_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/S0008-6363(99)00408-3","article-title":"Elf-pulsed magnetic fields modulate opioid peptide gene expression in myocardial cells","volume":"45","author":"Ventura","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2022.08.035_bib16","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1258\/ebm.2010.010122","article-title":"The influence of a 6 mT static magnetic field on apoptotic cell phagocytosis depends on monocyte\/macrophage differentiation","volume":"235","author":"Dini","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.bbrc.2022.08.035_bib17","first-page":"102","article-title":"Biological responses to permeability in liposome vesicles","volume":"108","author":"Lacy-Hulbert","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbrc.2022.08.035_bib18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/09553002.2011.538130","article-title":"DNA is a fractal antenna in electromagnetic fields","volume":"87","author":"Blank","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbrc.2022.08.035_bib19","first-page":"25","article-title":"Induction of chromosomal aberrations in human primary fibroblasts and immortalized cancer cells exposed to extremely-low-frequency electromagnetic fields, Iran","volume":"8","author":"Seyyedi","year":"2010","journal-title":"J.\u00a0Radiat. Res."},{"key":"10.1016\/j.bbrc.2022.08.035_bib20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.biopha.2017.10.090","article-title":"Corin protects H2O2-induced apoptosis through PI3K\/AKT and NF-\u03baB pathway in cardiomyocytes","volume":"97","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2022.08.035_bib21","first-page":"369","article-title":"Modification of membrane permeability measured by Texas-Red during cell cycle progression and differentiation","volume":"10","author":"Leonce","year":"1990","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2022.08.035_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2307\/3576974","article-title":"Magnetic field-induced drug permeability in liposome vesicles","volume":"108","author":"Liburdy","year":"1986","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbrc.2022.08.035_bib23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbrc.2012.08.078","article-title":"Electromagnetic fields instantaneously modulate nitric oxide signalling in challenged biological systems","volume":"426","author":"Pilla","year":"2012","journal-title":"BBRC (Biochem. Biophys. Res. Commun.)"},{"key":"10.1016\/j.bbrc.2022.08.035_bib24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1109\/TBME.2007.912636","article-title":"Effects of 900-MHz radio frequencies on the chemotaxis of human neutrophils in\u00a0vitro","volume":"55","author":"Aly","year":"2008","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.bbrc.2022.08.035_bib25","first-page":"672","article-title":"The electroporation effects of high power pulse microwave and electromagnetic pulse irradiation on the membranes of cardiomyocyte cells and the mechanism therein involved","volume":"22","author":"Deng","year":"2005","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"key":"10.1016\/j.bbrc.2022.08.035_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jcb.20198","article-title":"Extremely low fequency electromagnetic fields as effectors of cellular responses in\u00a0vitro: possible immune cell activation","volume":"93","author":"Simko","year":"2004","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2022.08.035_bib27","article-title":"Exposure to 1950-MHz TD-SCDMA electromagnetic fields affects the apoptosis of astrocytes via caspase-3-dependent pathway","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.08.035_bib28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/bem.21747","article-title":"Effects of low frequency electromagnetic field on proliferation of human epidermal stem cells: an in\u00a0vitro study","volume":"34","author":"Zhang","year":"2013","journal-title":"Bioelectromagnets"},{"key":"10.1016\/j.bbrc.2022.08.035_bib29","first-page":"1194","article-title":"FTIR spectra investigation of rat sensitive tissues explore exposure to ELF-EMF","volume":"32","author":"Li","year":"2012","journal-title":"Guang Pu Yu Guang Pu Fen Xi"},{"key":"10.1016\/j.bbrc.2022.08.035_bib30","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M211873200","article-title":"ERK and PhoA differentially regulate pseudopodia growth and retraction during chemotaxis","volume":"278","author":"Brahmbhatt","year":"2003","journal-title":"JBC"},{"key":"10.1016\/j.bbrc.2022.08.035_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/ajpheart.00728.2006","article-title":"Hic-5 promotes endothelial cell migration to lysophosphatic acid","volume":"293","author":"Avraamides","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2022.08.035_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/15368378.2011.566774","article-title":"Effects of a low-intensity electromagnetic field on fibroblast migration and proliferation","volume":"30","author":"Sunkari","year":"2011","journal-title":"Electromagn. Biol. Med."},{"key":"10.1016\/j.bbrc.2022.08.035_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2011.06.026","article-title":"Effects of 50 Hz sinusoidal electromagnetic fields of different intensities on proliferation, differentiation and mineralization potentials of rat osteoblasts","volume":"49","author":"Zhou","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2022.08.035_bib34","doi-asserted-by":"crossref","first-page":"936","DOI":"10.2174\/187152711799219325","article-title":"Kinetic study on the effects of extremely low frequency electromagnetic field on catalase, cytochrome P450 and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines","volume":"10","author":"Patruno","year":"2011","journal-title":"CNS Neurol. Disord.: Drug Targets"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22011548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22011548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:22:10Z","timestamp":1757766130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22011548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":34,"alternative-id":["S0006291X22011548"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.08.035","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}