{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:17:43Z","timestamp":1769926663701,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81625015"],"award-info":[{"award-number":["81625015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991510"],"award-info":[{"award-number":["81991510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991511"],"award-info":[{"award-number":["81991511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.bbrc.2022.09.042","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:34:32Z","timestamp":1663209272000},"page":"101-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice \u2013 Implications for postmenopausal obesity"],"prefix":"10.1016","volume":"630","author":[{"given":"Yanyan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongdong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meichen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozhi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-4781","authenticated-orcid":false,"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2022.09.042_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Collaborators","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"16","key":"10.1016\/j.bbrc.2022.09.042_bib2","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.2018.3060","article-title":"Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007-2008 to 2015-2016","volume":"319","author":"Hales","year":"2018","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.bbrc.2022.09.042_bib3","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.cell.2021.02.012","article-title":"Metabolic consequences of obesity and type 2 diabetes: balancing genes and environment for personalized care","volume":"184","author":"Pillon","year":"2021","journal-title":"Cell"},{"issue":"7755","key":"10.1016\/j.bbrc.2022.09.042_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41586-019-1171-x","article-title":"Rising rural body-mass index is the main driver of the global obesity epidemic in adults","volume":"569","author":"Bixby","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMra1514009","article-title":"Mechanisms, pathophysiology, and management of obesity","volume":"376","author":"Heymsfield","year":"2017","journal-title":"New Engl J Med"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.maturitas.2009.11.004","article-title":"Menopause is an independent predictor of metabolic syndrome in Iranian women","volume":"65","author":"Eshtiaghi","year":"2010","journal-title":"Maturitas"},{"issue":"10","key":"10.1016\/j.bbrc.2022.09.042_bib7","article-title":"Menopausal status and abdominal obesity are significant determinants of hepatic lipid metabolism in women","volume":"4","author":"Hodson","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"12","key":"10.1016\/j.bbrc.2022.09.042_bib8","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1210\/me.2012-1284","article-title":"Minireview: the year in review of estrogen regulation of metabolism","volume":"26","author":"Clegg","year":"2012","journal-title":"Mol Endocrinol"},{"issue":"2","key":"10.1016\/j.bbrc.2022.09.042_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/er.2001-0031","article-title":"Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone","volume":"24","author":"Labrie","year":"2003","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.bbrc.2022.09.042_bib10","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa219","article-title":"Insight on the intracrinology of menopause: androgen production within the human vagina","volume":"162","author":"Cellai","year":"2021","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bbrc.2022.09.042_bib11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/GME.0000000000000808","article-title":"Science of intracrinology in postmenopausal women","volume":"24","author":"Labrie","year":"2017","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.bbrc.2022.09.042_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1353\/pbm.1980.0064","article-title":"The adrenal functional unit: a hypothesis","volume":"23","author":"Carballeira","year":"1980","journal-title":"Perspect Biol Med"},{"issue":"20","key":"10.1016\/j.bbrc.2022.09.042_bib13","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.bbrc.2022.09.042_bib14","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1210\/en.2003-0126","article-title":"Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor","volume":"144","author":"Bielinska","year":"2003","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.bbrc.2022.09.042_bib15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1081\/ERC-200044147","article-title":"Nude mice as a model for gonadotropin-induced adrenocortical neoplasia","volume":"30","author":"Bielinska","year":"2004","journal-title":"Endocr Res"},{"issue":"4","key":"10.1016\/j.bbrc.2022.09.042_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jtemb.2012.03.002","article-title":"Excessive zinc in diet induces leptin resistance in Wistar rat through increased uptake of nutrients at intestinal level","volume":"26","author":"Taneja","year":"2012","journal-title":"J\u00a0Trace Elem Med Bio"},{"issue":"10108","key":"10.1016\/j.bbrc.2022.09.042_bib17","article-title":"Congenital adrenal hyperplasia (vol 390, pg 2194, 2017)","volume":"390","author":"El-Maouche","year":"2017","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.bbrc.2022.09.042_bib18","doi-asserted-by":"crossref","first-page":"11540","DOI":"10.1073\/pnas.94.21.11540","article-title":"Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia","volume":"94","author":"Caron","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbrc.2022.09.042_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jsbmb.2014.11.026","article-title":"The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)","volume":"151","author":"Yoshimoto","year":"2015","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"Pt A","key":"10.1016\/j.bbrc.2022.09.042_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jsbmb.2016.02.002","article-title":"Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic","volume":"165","author":"Auchus","year":"2017","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.bbrc.2022.09.042_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1677\/JOE-08-0353","article-title":"Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents","volume":"202","author":"Missaghian","year":"2009","journal-title":"J\u00a0Endocrinol"},{"issue":"1","key":"10.1016\/j.bbrc.2022.09.042_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1677\/joe.1.06972","article-title":"Adrenarche in the rat","volume":"191","author":"Pignatelli","year":"2006","journal-title":"J\u00a0Endocrinol"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1210\/en.2012-1953","article-title":"Ontogeny of the adrenal gland in the spiny mouse, with particular reference to production of the steroids cortisol and dehydroepiandrosterone","volume":"154","author":"Quinn","year":"2013","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.bbrc.2022.09.042_bib24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.cell.2014.01.007","article-title":"Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis","volume":"156","author":"Kim","year":"2014","journal-title":"Cell"},{"issue":"34","key":"10.1016\/j.bbrc.2022.09.042_bib25","doi-asserted-by":"crossref","first-page":"24085","DOI":"10.1074\/jbc.R600011200","article-title":"Mammalian zinc transport, trafficking, and signals","volume":"281","author":"Cousins","year":"2006","journal-title":"J\u00a0Biol Chem"},{"issue":"9","key":"10.1016\/j.bbrc.2022.09.042_bib26","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ni1373","article-title":"Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function","volume":"7","author":"Kitamura","year":"2006","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.bbrc.2022.09.042_bib27","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.numecd.2011.09.002","article-title":"The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project","volume":"23","author":"Wietlisbach","year":"2013","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends in obesity among US adults, 1999-2008","volume":"303","author":"Flegal","year":"2010","journal-title":"Jama-J Am Med Assoc"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/oby.21733","article-title":"Hair cortisol and adiposity in a population-based sample of 2,527 men and women aged 54 to 87 years","volume":"25","author":"Jackson","year":"2017","journal-title":"Obesity"},{"issue":"4","key":"10.1016\/j.bbrc.2022.09.042_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/gme.0b013e318271a640","article-title":"Association of estrogen with glucocorticoid levels in visceral fat in postmenopausal women","volume":"20","author":"Yamatani","year":"2013","journal-title":"Menopause"},{"issue":"11\u201312","key":"10.1016\/j.bbrc.2022.09.042_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1055\/s-2007-978680","article-title":"The abdominal obesity phenotype and insulin resistance are associated with abnormalities of the hypothalamic-pituitary-adrenal axis in humans","volume":"32","author":"Pasquali","year":"2000","journal-title":"Horm Metab Res"},{"issue":"8","key":"10.1016\/j.bbrc.2022.09.042_bib32","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1007\/s00394-018-1876-x","article-title":"The association between serum zinc level and overweight\/obesity: a meta-analysis","volume":"58","author":"Gu","year":"2019","journal-title":"Eur J Nutr"},{"issue":"1","key":"10.1016\/j.bbrc.2022.09.042_bib33","first-page":"57","article-title":"Influence of cortisol on zinc metabolism in morbidly obese women","volume":"29","author":"Martins","year":"2014","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.bbrc.2022.09.042_bib34","first-page":"339","article-title":"Serum trace elements in obese women with or without diabetes","volume":"137","author":"Yerlikaya","year":"2013","journal-title":"Indian J Med Res"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1442-200X.1997.tb03748.x","article-title":"Serum zinc, copper, and magnesium levels in obese children","volume":"39","author":"Yakinci","year":"1997","journal-title":"Acta Paediatr Jpn"},{"issue":"5","key":"10.1016\/j.bbrc.2022.09.042_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ramb.2013.03.003","article-title":"Plasma concentration of IL-6 and TNF-alpha and its relationship with zincemia in obese women","volume":"59","author":"Feitosa","year":"2013","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"8","key":"10.1016\/j.bbrc.2022.09.042_bib37","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s00394-015-1048-1","article-title":"Increased risk of iron deficiency and reduced iron absorption but no difference in zinc, vitamin A or B-vitamin status in obese women in India","volume":"55","author":"Herter-Aeberli","year":"2016","journal-title":"Eur J Nutr"},{"issue":"1","key":"10.1016\/j.bbrc.2022.09.042_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s13098-019-0497-8","article-title":"Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial","volume":"11","author":"Khorsandi","year":"2019","journal-title":"Diabetol Metab Syndr"},{"issue":"10","key":"10.1016\/j.bbrc.2022.09.042_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101138","article-title":"Chronic high dose zinc supplementation induces visceral adipose tissue hypertrophy without altering body weight in mice","volume":"9","author":"Huang","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.bbrc.2022.09.042_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12011-016-0835-8","article-title":"The effect of zinc supplementation on insulin resistance in obese subjects: a systematic review","volume":"176","author":"Cruz","year":"2017","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"10.1016\/j.bbrc.2022.09.042_bib41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02789454","article-title":"Zinc supplementation aggravates body fat accumulation in genetically obese mice and dietary-obese mice","volume":"52","author":"Chen","year":"1996","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"10.1016\/j.bbrc.2022.09.042_bib42","doi-asserted-by":"crossref","first-page":"E465","DOI":"10.1210\/jc.2011-2413","article-title":"A\u00a0missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency","volume":"97","author":"Idkowiak","year":"2012","journal-title":"J\u00a0Clin Endocr Metab"},{"issue":"6","key":"10.1016\/j.bbrc.2022.09.042_bib43","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1210\/jc.2010-2888","article-title":"Clinical review: DHEA replacement for postmenopausal women","volume":"96","author":"Davis","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.bbrc.2022.09.042_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2019.108507","article-title":"Pharmacological activities of dehydroepiandrosterone: a review","volume":"153","author":"Sahu","year":"2020","journal-title":"Steroids"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2201292X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2201292X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:22:17Z","timestamp":1757766137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2201292X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":44,"alternative-id":["S0006291X2201292X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.09.042","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice \u2013 Implications for postmenopausal obesity","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.09.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}