{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:13:46Z","timestamp":1790720026257,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2019JJ80037"],"award-info":[{"award-number":["2019JJ80037"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2020RC3065"],"award-info":[{"award-number":["2020RC3065"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bbrc.2022.09.063","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T10:46:59Z","timestamp":1664016419000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Comparison of the chronic unpredictable mild stress and the maternal separation in mice postpartum depression modeling"],"prefix":"10.1016","volume":"632","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhuang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishuo","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.09.063_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/da.22719","article-title":"A\u00a0longitudinal study of women's depression symptom profiles during and after the postpartum phase","volume":"35","author":"Fox","year":"2018","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.bbrc.2022.09.063_bib2","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20182382","article-title":"Neuroprotection of reduced thyroid hormone with increased estrogen and progestogen in postpartum depression","volume":"39","author":"Li","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbrc.2022.09.063_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tins.2016.11.009","article-title":"The neurobiology of postpartum anxiety and depression","volume":"40","author":"Pawluski","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2022.09.063_bib4","first-page":"133","article-title":"Research progress on animal models of postpartum depression and their behavior evaluation methods","volume":"26","author":"Tang","year":"2018","journal-title":"Acta Lab. Anim. Sci. Sin."},{"key":"10.1016\/j.bbrc.2022.09.063_bib5","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1038\/s41467-020-19931-2","article-title":"Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system","volume":"11","author":"Chevalier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2022.09.063_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s40168-019-0733-3","article-title":"Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2","volume":"7","author":"Zhang","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.bbrc.2022.09.063_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.physbeh.2016.12.003","article-title":"Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression","volume":"169","author":"Liu","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2022.09.063_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2017.02.006","article-title":"Behavioral effects in adolescence and early adulthood in two length models of maternal separation in male rats","volume":"324","author":"Banqueri","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2022.09.063_bib9","first-page":"234","article-title":"Effect of maternal deprivation on exploratory behavior and CR expression in hippocampus of rats","volume":"15","author":"Hao","year":"2016","journal-title":"Chin. J. Neurosurg. Dis. Res."},{"key":"10.1016\/j.bbrc.2022.09.063_bib10","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S1734-1140(13)71505-6","article-title":"Early maternal separation: a rodent model of depression and a prevailing human condition","volume":"65","author":"Vetulani","year":"2013","journal-title":"Pharmacol. Rep. : PR"},{"key":"10.1016\/j.bbrc.2022.09.063_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.psyneuen.2006.10.004","article-title":"Repeated long separations from pups produce depression-like behavior in rat mothers","volume":"32","author":"Boccia","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbrc.2022.09.063_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jad.2021.09.064","article-title":"T\u00a0cell responses in depressed mice induced by chronic unpredictable mild stress","volume":"296","author":"Shi","year":"2021","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.bbrc.2022.09.063_bib13","first-page":"321","article-title":"Research progress on animal models of depression and their evaluation methods","volume":"23","author":"Xue","year":"2015","journal-title":"Acta Lab. Anim. Sci. Sin."},{"key":"10.1016\/j.bbrc.2022.09.063_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-8994-2_4","article-title":"The elevated plus maze test for measuring anxiety-like behavior in rodents","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2022.09.063_bib15","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2022.09.063_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbr.2014.05.036","article-title":"Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats","volume":"271","author":"Arbabi","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2022.09.063_bib17","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ismej.2015.131","article-title":"Experimental insights into the importance of aquatic bacterial community composition to the degradation of dissolved organic matter","volume":"10","author":"Logue","year":"2016","journal-title":"ISME J."},{"key":"10.1016\/j.bbrc.2022.09.063_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbr.2006.06.025","article-title":"BALB\/c mice: low sociability and other phenotypes that may be relevant to autism","volume":"176","author":"Brodkin","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2022.09.063_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13041-018-0355-x","article-title":"Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression","volume":"11","author":"Li","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbrc.2022.09.063_bib20","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.3892\/etm.2017.4930","article-title":"Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity","volume":"14","author":"Zhang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbrc.2022.09.063_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbr.2015.11.011","article-title":"An investigation into the effects of antenatal stressors on the postpartum neuroimmune profile and depressive-like behaviors","volume":"298","author":"Posillico","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2022.09.063_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yfrne.2018.12.001","article-title":"Pathophysiological mechanisms implicated in postpartum depression","volume":"52","author":"Payne","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbrc.2022.09.063_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13041-020-00631-3","article-title":"The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice","volume":"13","author":"Liu","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbrc.2022.09.063_bib24","first-page":"6103","article-title":"Correlation of plasm orphanin level and monoamine neurotransmitters in patients with postpartum depression","author":"Hu","year":"2007","journal-title":"J.\u00a0Clin. Rehabilitative Tissue Eng. Res."},{"key":"10.1016\/j.bbrc.2022.09.063_bib25","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200672","article-title":"LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression","volume":"40","author":"Zhu","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbrc.2022.09.063_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41398-020-0704-2","article-title":"Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression","volume":"10","author":"Zoubovsky","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbrc.2022.09.063_bib27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.21037\/atm-20-4411","article-title":"Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice","volume":"9","author":"Qiu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bbrc.2022.09.063_bib28","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1039\/D0FO00373E","article-title":"Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota","volume":"11","author":"Gu","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.bbrc.2022.09.063_bib29","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41380-019-0380-x","article-title":"The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats","volume":"25","author":"Pearson-Leary","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbrc.2022.09.063_bib30","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3389\/fphar.2018.00967","article-title":"Antidepressant-like effects of Cistanche tubulosa extract on chronic unpredictable stress rats through restoration of gut microbiota homeostasis","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.09.063_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbi.2019.03.006","article-title":"Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner","volume":"80","author":"Rincel","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbrc.2022.09.063_bib32","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1038\/s41598-019-40140-5","article-title":"Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice","volume":"9","author":"McGaughey","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.09.063_bib33","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations","volume":"596","author":"van de Wouw","year":"2018","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2022.09.063_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150559","article-title":"Chronic psychological stress disrupted the composition of the murine colonic microbiota and accelerated a murine model of inflammatory bowel disease","volume":"11","author":"Watanabe","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2022.09.063_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.psyneuen.2015.10.001","article-title":"Structural & functional consequences of chronic psychosocial stress on the microbiome & host","volume":"63","author":"Bharwani","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbrc.2022.09.063_bib36","first-page":"229","article-title":"Diversity of intestinal flora in commonly used SPF mice and rats","volume":"27","author":"Huang","year":"2019","journal-title":"Acta Lab. Anim. Sci. Sin."},{"key":"10.1016\/j.bbrc.2022.09.063_bib37","article-title":"Xiaoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota","volume":"112","author":"Zhu","year":"2019","journal-title":"Biomed. Pharmacother.\u00a0= Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.bbrc.2022.09.063_bib38","first-page":"3316","article-title":"Study on establishment of anxiety type psychological stress-insomnia model in SD rats by electric shock","volume":"27","author":"Zhang","year":"2018","journal-title":"Modern J. Integrat. Tradl. Chin. Western Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22013195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22013195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:44:16Z","timestamp":1762094656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22013195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":38,"alternative-id":["S0006291X22013195"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.09.063","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the chronic unpredictable mild stress and the maternal separation in mice postpartum depression modeling","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.09.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}