{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:43:07Z","timestamp":1781610187711,"version":"3.54.5"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K19666"],"award-info":[{"award-number":["JP17K19666"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H05767A02"],"award-info":[{"award-number":["JP19H05767A02"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20FC1049"],"award-info":[{"award-number":["20FC1049"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","award":["5-4"],"award-info":[{"award-number":["5-4"]}],"id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","award":["2021A3117"],"award-info":[{"award-number":["2021A3117"]}],"id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bbrc.2022.11.106","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T01:08:36Z","timestamp":1670202516000},"page":"21-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Role of phosphate transporter PiT-2 in the pathogenesis of primary brain calcification"],"prefix":"10.1016","volume":"640","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-4920","authenticated-orcid":false,"given":"Masatoshi","family":"Inden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Nishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Masaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Takase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Ohuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaka","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Hozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.11.106_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ng.1077","article-title":"Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis","volume":"44","author":"Wang","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2022.11.106_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jphs.2021.11.004","article-title":"Characteristics and therapeutic potential of sodium-dependent phosphate cotransporters in relation to idiopathic basal ganglia calcification","volume":"148","author":"Inden","year":"2022","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2022.11.106_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12031-016-0868-7","article-title":"Primary brain calcification causal PiT2 transport-knockout variants can exert dominant negative effects on wild-type PiT2 transport function in mammalian cells","volume":"61","author":"Larsen","year":"2017","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2022.11.106_bib4","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1002\/jcp.26104","article-title":"Primary familial brain calcification with a novel SLC20A2 mutation: analysis of PiT-2 expression and localization","volume":"233","author":"Taglia","year":"2018","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2022.11.106_bib5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1212\/WNL.0000000000000143","article-title":"Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in Japan","volume":"82","author":"Yamada","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2022.11.106_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2019.01.096","article-title":"SLC20A2 variants cause dysfunctional phosphate transport activity in endothelial cells induced from Idiopathic Basal Ganglia Calcification patients-derived iPSCs","volume":"510","author":"Sekine","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.11.106_bib7","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1128\/JVI.76.9.4304-4311.2002","article-title":"Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration","volume":"76","author":"Sala\u00fcn","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2022.11.106_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53401-0","article-title":"Partial reduced Pi transport function of PiT-2 might not be sufficient to induce brain calcification of idiopathic basal ganglia calcification","volume":"9","author":"Nishii","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.11.106_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-06406-6","article-title":"Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells","volume":"7","author":"Takase","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.11.106_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79189-y","article-title":"The neuroprotective effects of activated \u03b17 nicotinic acetylcholine receptor against mutant copper\u2013zinc superoxide dismutase 1-mediated toxicity","volume":"10","author":"Ito","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.11.106_bib11","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1074\/jbc.M117.807339","article-title":"Phosphate (pi)-regulated heterodimerization of the high affinity sodium-dependent pi transporters pit1\/slc20a1 and pit2\/slc20a2 underlies extracellular pi sensing independently of pi uptake","volume":"293","author":"Bon","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.11.106_bib12","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/mds.28090","article-title":"Haploinsufficiency of the primary familial brain calcification gene SLC20A2 mediated by disruption of a regulatory element","volume":"35","author":"Cassinari","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbrc.2022.11.106_bib13","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11910-014-0490-4","article-title":"The genetics of primary familial brain calcifications","volume":"14","author":"Westenberger","year":"2014","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.bbrc.2022.11.106_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/humu.22778","article-title":"Update and mutational analysis of SLC20A2: a major cause of primary familial brain calcification","volume":"36","author":"Lemos","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrc.2022.11.106_bib15","doi-asserted-by":"crossref","first-page":"C1377","DOI":"10.1152\/ajpcell.00015.2006","article-title":"Characterization of transport mechanisms and determinants critical for Na\u00a0+ -dependent P i symport of the PiT family paralogs human PiT1 and PiT2","volume":"291","author":"B\u00f8ttger","year":"2006","journal-title":"Am. J. Physiol. Physiol."},{"key":"10.1016\/j.bbrc.2022.11.106_bib16","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.1128\/JVI.75.12.5584-5592.2001","article-title":"Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor","volume":"75","author":"Salaun","year":"2002","journal-title":"J.\u00a0Virol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:23:40Z","timestamp":1757766220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22016631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":16,"alternative-id":["S0006291X22016631"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.11.106","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of phosphate transporter PiT-2 in the pathogenesis of primary brain calcification","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.11.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}