{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:59:21Z","timestamp":1770148761639,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013277","name":"National Clinical Key Specialty Project Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013277","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bbrc.2022.12.010","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T03:34:06Z","timestamp":1670470446000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["LIPUS accelerates bone regeneration via HDAC6-mediated ciliogenesis"],"prefix":"10.1016","volume":"641","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-4559","authenticated-orcid":false,"given":"Han","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.12.010_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15122845","article-title":"Incidence, costs and predictors of non-union, delayed union and mal-union following long bone fracture","volume":"15","author":"Ekegren","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.bbrc.2022.12.010_bib2","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.O.00027","article-title":"Enhancement of bone-healing by low-intensity pulsed ultrasound: a systematic review","volume":"4","author":"Rutten","year":"2016","journal-title":"JBJS Rev"},{"key":"10.1016\/j.bbrc.2022.12.010_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17071057","article-title":"Effects and mechanisms of low-intensity pulsed ultrasound for chronic prostatitis and chronic pelvic pain syndrome","volume":"17","author":"Lin","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.12.010_bib4","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1109\/TBME.2018.2889669","article-title":"A\u00a0review of low-intensity pulsed ultrasound for therapeutic applications","volume":"66","author":"Jiang","year":"2019","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.bbrc.2022.12.010_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldr006","article-title":"The evidence of low-intensity pulsed ultrasound for in\u00a0vitro, animal and human fracture healing","volume":"100","author":"Martinez de Albornoz","year":"2011","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbrc.2022.12.010_bib6","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1002\/jcb.26418","article-title":"Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling","volume":"119","author":"Matsumoto","year":"2018","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2022.12.010_bib7","series-title":"Low-Intensity Pulsed Ultrasound Stimulates Osteogenic Differentiation of Periosteal Cells in\u00a0Vitro, Tissue Eng Part A","author":"Maung","year":"2020"},{"key":"10.1016\/j.bbrc.2022.12.010_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/ten.tea.2019.0331","article-title":"Low-intensity pulsed ultrasound stimulates osteogenic differentiation of periosteal cells in\u00a0vitro","volume":"27","author":"Maung","year":"2021","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bbrc.2022.12.010_bib9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00774-013-0429-x","article-title":"Periosteal cells are a major source of soft callus in bone fracture","volume":"31","author":"Murao","year":"2013","journal-title":"J.\u00a0Bone Miner. Metabol."},{"key":"10.1016\/j.bbrc.2022.12.010_bib10","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.217828","article-title":"Primary cilia are necessary for Prx1-expressing cells to contribute to postnatal skeletogenesis","volume":"131","author":"Moore","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2022.12.010_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13287-018-0930-1","article-title":"Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation","volume":"9","author":"Moore","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2022.12.010_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112272","article-title":"Primary cilium-dependent signaling mechanisms","volume":"18","author":"Pala","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2022.12.010_bib13","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10439-015-1274-y","article-title":"Low-intensity pulsed ultrasound in dentofacial tissue engineering","volume":"43","author":"Tanaka","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bbrc.2022.12.010_bib14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.celrep.2018.06.083","article-title":"Differential HDAC6 activity modulates ciliogenesis and subsequent mechanosensing of endothelial cells derived from pluripotent stem cells","volume":"24","author":"Smith","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2022.12.010_bib15","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1111\/jcmm.15891","article-title":"Periosteum progenitors could stimulate bone regeneration in aged murine bone defect model","volume":"24","author":"Xiao","year":"2020","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2022.12.010_bib16","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.injury.2016.09.023","article-title":"Heal rate of metatarsal fractures: a propensity-matching study of patients treated with low-intensity pulsed ultrasound (LIPUS) vs. surgical and other treatments","volume":"47","author":"Nolte","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.bbrc.2022.12.010_bib17","doi-asserted-by":"crossref","first-page":"j576","DOI":"10.1136\/bmj.j576","article-title":"Low intensity pulsed ultrasound (LIPUS) for bone healing: a clinical practice guideline","volume":"356","author":"Poolman","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.bbrc.2022.12.010_bib18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/0019-5413.50847","article-title":"Low-intensity pulsed ultrasound: fracture healing","volume":"43","author":"Mundi","year":"2009","journal-title":"Indian J. Orthop."},{"key":"10.1016\/j.bbrc.2022.12.010_bib19","article-title":"LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.12.010_bib20","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1080\/21691401.2019.1657878","article-title":"Low intensity pulsed ultrasound promotes the migration of bone marrow- derived mesenchymal stem cells via activating FAK-ERK1\/2 signalling pathway","volume":"47","author":"Chen","year":"2019","journal-title":"Artif. Cell Nanomed. Biotechnol."},{"key":"10.1016\/j.bbrc.2022.12.010_bib21","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/01.bot.0000489982.40329.52","article-title":"9. Effects of low-intensity pulsed ultrasound (LIPUS) on osteoclasts and osteoblasts: analysis using an assay system with fish scale as a model of bone","volume":"30","author":"Suzuki","year":"2016","journal-title":"J.\u00a0Orthop. Trauma"},{"key":"10.1016\/j.bbrc.2022.12.010_bib22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbrc.2009.06.059","article-title":"Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum","volume":"386","author":"Kawanami","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.12.010_bib23","article-title":"Prx1-Expressing progenitor primary cilia mediate bone formation in response to mechanical loading in mice","volume":"2019","author":"Moore","year":"2019","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.bbrc.2022.12.010_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pbiomolbio.2006.07.005","article-title":"Therapeutic applications of ultrasound","volume":"93","author":"ter Haar","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bbrc.2022.12.010_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-397944-5.00001-8","article-title":"Non-motile primary cilia as fluid shear stress mechanosensors","volume":"525","author":"Nauli","year":"2013","journal-title":"Methods Enzymol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:44:20Z","timestamp":1762094660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22016783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":25,"alternative-id":["S0006291X22016783"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.12.010","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LIPUS accelerates bone regeneration via HDAC6-mediated ciliogenesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}