{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:38:26Z","timestamp":1772120306385,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SR\/S2\/JCB-41\/2010"],"award-info":[{"award-number":["SR\/S2\/JCB-41\/2010"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008605","name":"Indian National Science Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bbrc.2022.12.018","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T19:59:02Z","timestamp":1670356742000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3"],"prefix":"10.1016","volume":"641","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-5974","authenticated-orcid":false,"given":"Akhouri Kishore","family":"Raghawan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-4650","authenticated-orcid":false,"given":"Rajashree","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-0509","authenticated-orcid":false,"given":"Ghanshyam","family":"Swarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.12.018_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41421-020-0167-x","article-title":"Inflammasome activation and regulation: toward a better understanding of complex mechanisms","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell Discovery"},{"key":"10.1016\/j.bbrc.2022.12.018_bib2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.12.018_bib3","series-title":"Inflammasomes in the pathophysiology of autoinflammatory syndromes","first-page":"379","volume":"107","author":"Tartey","year":"2020"},{"key":"10.1016\/j.bbrc.2022.12.018_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10875-019-00638-z","article-title":"CAPS and NLRP3","volume":"39","author":"Booshehri","year":"2019","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.bbrc.2022.12.018_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2022.12.018_bib6","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1086\/340786","article-title":"New mutations of CIAS1 that are responsible for muckle-wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes","volume":"70","author":"Dod\u00e9","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2022.12.018_bib7","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1002\/art.10509","article-title":"Association of mutations in the NALP3\/CIAS1\/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis","volume":"46","author":"Aganna","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2022.12.018_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00439-002-0860-x","article-title":"Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P","volume":"112","author":"Hoffman","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbrc.2022.12.018_bib9","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.4049\/jimmunol.175.4.2630","article-title":"IL-converting enzyme\/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients","volume":"175","author":"Stack","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2022.12.018_bib10","first-page":"2085","article-title":"Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease","volume":"33","author":"Metyas","year":"2006","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.bbrc.2022.12.018_bib11","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/art.22491","article-title":"The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model","volume":"56","author":"Aksentijevich","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2022.12.018_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/rheumatology\/kem318","article-title":"New CIAS1 mutation and anakinra efficacy in overlapping of Muckle-Wells and familial cold autoinflammatory syndromes","volume":"47","author":"Maksimovic","year":"2008","journal-title":"Rheumatology"},{"key":"10.1016\/j.bbrc.2022.12.018_bib13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jaci.2006.12.649","article-title":"Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia","volume":"119","author":"Rosengren","year":"2007","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2022.12.018_bib14","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/art.23620","article-title":"A\u00a0pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome","volume":"58","author":"Goldbach-Mansky","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2022.12.018_bib15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2009.05.005","article-title":"Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity","volume":"30","author":"Brydges","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2022.12.018_bib16","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/art.23687","article-title":"Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies","volume":"58","author":"Hoffman","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2022.12.018_bib17","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/archderm.142.12.1591","article-title":"Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1\/NALP3 mutations","volume":"142","author":"Leslie","year":"2006","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.bbrc.2022.12.018_bib18","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0140-6736(04)17401-1","article-title":"Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist","volume":"364","author":"Hoffman","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2022.12.018_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2310\/7750.2008.07050","article-title":"Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up","volume":"12","author":"Ross","year":"2008","journal-title":"J.\u00a0Cutan. Med. Surg."},{"key":"10.1016\/j.bbrc.2022.12.018_bib20","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1084\/jem.20082481","article-title":"In\u00a0vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes","volume":"206","author":"Lachmann","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2022.12.018_bib21","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1136\/ard.2011.152728","article-title":"Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes","volume":"70","author":"Kuemmerle-Deschner","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2022.12.018_bib22","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1002\/art.38811","article-title":"Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS)","volume":"66","author":"Chang","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2022.12.018_bib23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41419-019-1491-7","article-title":"HSP70 is a negative regulator of NLRP3 inflammasome activation","volume":"10","author":"Martine","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2022.12.018_bib24","doi-asserted-by":"crossref","first-page":"21694","DOI":"10.1073\/pnas.1905261116","article-title":"HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4","volume":"116","author":"Raghawan","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2022.12.018_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1379\/1466-1268(1996)001<0078:TAOTBH>2.3.CO;2","article-title":"Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer","volume":"1","author":"Leung","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.bbrc.2022.12.018_bib26","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1074\/jbc.M116.763979","article-title":"A\u00a0disease-associated mutant of NLRC4 shows enhanced interaction with SUG1 leading to constitutive FADD-dependent caspase-8 activation and cell death","volume":"292","author":"Raghawan","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.12.018_bib27","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4161\/auto.26448","article-title":"HSPA8\/HSC70 chaperone protein: structure, function, and chemical targeting","volume":"9","author":"Stricher","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2022.12.018_bib28","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1073\/pnas.1402911111","article-title":"Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex","volume":"111","author":"Man","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2022.12.018_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/srep36214","article-title":"Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis","volume":"6","author":"Chung","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2022.12.018_bib30","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.1074\/jbc.M100200200","article-title":"A\u00a0role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135)","volume":"276","author":"Akakura","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.12.018_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2022.12.018_bib32","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1073\/pnas.1217431110","article-title":"TRPM8 activation attenuates inflammatory responses in mouse models of colitis","volume":"110","author":"Ramachandran","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2022.12.018_bib33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.cellsig.2016.05.010","article-title":"Cool-temperature-mediated activation of phospholipase C-\u03b32 in the human hereditary disease PLAID","volume":"28","author":"Schade","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2022.12.018_bib34","series-title":"HSC70 as a Sensor of Low Temperature: Role in Cold-Triggered Autoinflammatory Disorders","author":"Raghawan","year":"2021"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:44:31Z","timestamp":1762094671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22016837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":34,"alternative-id":["S0006291X22016837"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.12.018","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.11.16.516705","asserted-by":"object"}]},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}