{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:41Z","timestamp":1792789661061,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100022108","name":"Universit\u00e9 de Poitiers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bbrc.2022.12.027","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T01:54:14Z","timestamp":1671242054000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Pro-inflammatory cytokine secretion induced by amyloid transthyretin in human cardiac fibroblasts"],"prefix":"10.1016","volume":"642","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-1880","authenticated-orcid":false,"given":"Christophe","family":"Magaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Harnois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6966-9437","authenticated-orcid":false,"given":"Stephane","family":"Sebille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-1182","authenticated-orcid":false,"given":"Aurelien","family":"Chatelier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Faivre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guylene","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnabas","family":"Gellen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2022.12.027_bib1","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/01.CIR.0000034511.06350.DF","article-title":"Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation","volume":"106","author":"R\u00f6cken","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2022.12.027_bib2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.amjcard.2015.05.021","article-title":"Characterization of cardiac amyloidosis by atrial late gadolinium enhancement using contrast enhanced cardiac magnetic resonance imaging and correlation with left atrial conduit and contractile function","volume":"116","author":"Kwong","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib3","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/eurheartj\/ehv338","article-title":"Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction","volume":"36","author":"Gonz\u00e1lez-L\u00f3pez","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2022.12.027_bib4","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.jacc.2019.04.003","article-title":"Transthyretin amyloid cardiomyopathy","volume":"73","author":"Ruberg","year":"2019","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/jcp.25624","article-title":"Basic signaling in cardiac fibroblasts: basic signaling in cardiac fibroblasts","volume":"232","author":"Chacar","year":"2017","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib6","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00763.2004","article-title":"Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol","volume":"288","author":"Olson","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.vph.2012.07.003","article-title":"The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction","volume":"58","author":"van Nieuwenhoven","year":"2013","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0008-6363(00)00030-4","article-title":"Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis","volume":"46","author":"MacKenna","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2022.12.027_bib9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yjmcc.2007.05.006","article-title":"Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms","volume":"43","author":"Turner","year":"2007","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.biocel.2011.06.008","article-title":"Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation","volume":"43","author":"Turner","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1009806403194","article-title":"Extracellular matrix and growth factors during heart growth","volume":"5","author":"Corda","year":"2000","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.bbrc.2022.12.027_bib12","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00073.2021","article-title":"Transthyretin amyloid fibrils alter primary fibroblast structure, function, and inflammatory gene expression","volume":"321","author":"Dittloff","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib13","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M602302200","article-title":"Endoplasmic reticulum stress associated with extracellular aggregates. Evidence from transthyretin deposition in familial amyloid polyneuropathy","volume":"281","author":"Teixeira","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2022.12.027_bib14","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1113\/jphysiol.2012.233593","article-title":"A\u00a0distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts","volume":"590","author":"Chatelier","year":"2012","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbrc.2005.12.038","article-title":"A\u00a0voltage-activated proton current in human cardiac fibroblasts","volume":"340","author":"El Chemaly","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2022.12.027_bib16","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.bbamem.2008.04.005","article-title":"Implication of connexins 40 and 43 in functional coupling between mouse cardiac fibroblasts in primary culture","volume":"1778","author":"Louault","year":"2008","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbrc.2022.12.027_bib17","article-title":"Cytokine-mediated alterations of human cardiac fibroblast's secretome","volume":"22","author":"Br\u00e4uninger","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.bbrc.2022.12.027_bib18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/paa.1999.111.5.406","article-title":"The natriuretic peptides in heart failure: diagnostic and therapeutic potentials","volume":"111","author":"Chen","year":"1999","journal-title":"Proc. Assoc. Am. Phys."},{"key":"10.1016\/j.bbrc.2022.12.027_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejheart.2003.12.015","article-title":"Essential biochemistry and physiology of (NT-pro)BNP","volume":"6","author":"Hall","year":"2004","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbrc.2022.12.027_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/13506129.2013.844122","article-title":"Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy","volume":"20","author":"Usuku","year":"2013","journal-title":"Amyloid"},{"key":"10.1016\/j.bbrc.2022.12.027_bib21","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.smim.2014.01.009","article-title":"A\u00a0new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy","volume":"26","author":"Tanaka","year":"2014","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cardiores.2004.01.027","article-title":"Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction","volume":"62","author":"Camelliti","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2022.12.027_bib24","doi-asserted-by":"crossref","first-page":"H1694","DOI":"10.1152\/ajpheart.00908.2008","article-title":"IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart","volume":"296","author":"Banerjee","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jcp.20307","article-title":"Role of interleukin-6 in cardiomyocyte\/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation","volume":"204","author":"Fredj","year":"2005","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/14397595.2018.1515145","article-title":"AA amyloidosis \u2013 benefits and prospects of IL-6 inhibitors","volume":"29","author":"Okuda","year":"2019","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.bbrc.2022.12.027_bib27","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.2169\/internalmedicine.1099-18","article-title":"First nationwide survey of 199 patients with amyloid A amyloidosis in Japan","volume":"57","author":"Okuda","year":"2018","journal-title":"Intern. Med."},{"key":"10.1016\/j.bbrc.2022.12.027_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107424","article-title":"Role of neutrophils in ischemic heart failure","volume":"205","author":"Kain","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2022.12.027_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.bbrc.2022.12.027_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.005868","article-title":"Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis","volume":"2","author":"Tanaka","year":"2013","journal-title":"JAHA"},{"key":"10.1016\/j.bbrc.2022.12.027_bib31","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/labinvest.2013.83","article-title":"Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis","volume":"93","author":"Misumi","year":"2013","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbrc.2022.12.027_bib32","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.bpj.2016.09.010","article-title":"Biochemical and electrophysiological modification of amyloid transthyretin on cardiomyocytes","volume":"111","author":"Sartiani","year":"2016","journal-title":"Biophys. J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X22016928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:45:27Z","timestamp":1762094727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X22016928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":32,"alternative-id":["S0006291X22016928"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.12.027","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pro-inflammatory cytokine secretion induced by amyloid transthyretin in human cardiac fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2022.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}