{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:12:06Z","timestamp":1787587926538,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["3221"],"award-info":[{"award-number":["3221"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.bbrc.2023.03.011","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T19:43:37Z","timestamp":1678131817000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effects of pharmacological primary cilium disturbance in the context of in\u00a0vitro 2D and 3D malignant pleura mesothelioma"],"prefix":"10.1016","volume":"654","author":[{"given":"Rajesh M.","family":"Jagirdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-1041","authenticated-orcid":false,"given":"Eleanna","family":"Pitaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania S.","family":"Kotsiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-4510","authenticated-orcid":false,"given":"Erasmia","family":"Rouka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-260X","authenticated-orcid":false,"given":"Sotirios I.","family":"Sinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Varsamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Marnas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elpiniki","family":"Stergiopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Giannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrissi","family":"Hatzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos I.","family":"Gourgoulianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios G.","family":"Zarogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2023.03.011_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.physiol.69.040705.141236","article-title":"Overview of structure and function of mammalian cilia","volume":"69","author":"Satir","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/jcs.050377","article-title":"The primary cilium at a glance","volume":"123","author":"Satir","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2023.03.011_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2046-2530-2-6","article-title":"Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis","volume":"2","author":"Basten","year":"2013","journal-title":"Cilia"},{"key":"10.1016\/j.bbrc.2023.03.011_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-679X(08)94007-3","article-title":"Primary cilia and the cell cycle","volume":"94","author":"Plotnikova","year":"2009","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib5","doi-asserted-by":"crossref","unstructured":"Cao, H.T.: Liu, M.M.: Shao, Q.N.: Jiao, Z.Y. The role of the primary cilium in cancer. Neoplasma. 202, 68, 899-906.","DOI":"10.4149\/neo_2021_210210N204"},{"key":"10.1016\/j.bbrc.2023.03.011_bib6","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1002\/jcp.30117","article-title":"Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer","volume":"236","author":"Wang","year":"2021","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cellbi.2003.11.010","article-title":"Mesothelial primary cilia of peritoneal and other serosal surfaces","volume":"28","author":"Bird","year":"2004","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2023.03.011_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cellbi.2003.11.014","article-title":"Cultured peritoneal mesothelial cells exhibit apical primary cilia","volume":"28","author":"Bird","year":"2004","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2023.03.011_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1042\/CBI20100593","article-title":"Thiols stabilize cobblestone morphology of cultured mesothelial cells","volume":"35","author":"Bird","year":"2011","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2023.03.011_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.resp.2007.07.002","article-title":"Pleural liquid and its exchanges","volume":"159","author":"Agostoni","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/MCP.0000000000000170","article-title":"Can pharmacologic agents speed the rate of resorption of pleural fluid?","volume":"21","author":"Zarogiannis","year":"2015","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.bbrc.2023.03.011_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2020.103581","article-title":"Pleural effusion osmolality correlation with pH and glucose level of pleural fluid and its effects on the pleural membrane permeability","volume":"285","author":"Peppa","year":"2021","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1152\/ajplung.00051.2015","article-title":"Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma","volume":"309","author":"Vavougios","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib14","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ncb2560","article-title":"The BBSome controls IFT assembly and turnaround in cilia","volume":"14","author":"Wei","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1091\/mbc.e08-07-0741","article-title":"Deciliation is associated with dramatic remodeling of epithelial cell junctions and surface domains","volume":"20","author":"Overgaard","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2023.03.011_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00795-014-0076-x","article-title":"The elongation of primary cilia via the acetylation of \u03b1-tubulin by the treatment with lithium chloride in human fibroblast KD cells","volume":"48","author":"Nakakura","year":"2015","journal-title":"Med. Mol. Morphol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1096\/fj.15-274944","article-title":"Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling","volume":"30","author":"Thompson","year":"2016","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2023.03.011_bib18","article-title":"Changes in global gene expression associated with 3D structure of tumors: an ex\u00a0vivo matrix-free mesothelioma spheroid model","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2023.03.011_bib19","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1007\/s10753-019-01070-6","article-title":"Pleural effusion IL-33\/sST2 levels and effects of low and high IL-33\/sST2 levels on human mesothelial cell adhesion and migration","volume":"42","author":"Kotsiou","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2023.03.011_bib20","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3390\/ijms20061336","article-title":"Primary cilium in cancer hallmarks","volume":"20","author":"Fabbri","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.03.011_bib21","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.3390\/cancers14215216","article-title":"Analysis of primary cilium expression and hedgehog pathway activation in mesothelioma throws back its complex biology","volume":"14","author":"Barbarino","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2023.03.011_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/jdb10040052","article-title":"Life-saver or undertaker: the relationship between primary cilia and cell death in vertebrate embryonic development","volume":"10","author":"Pfirrmann","year":"2022","journal-title":"J.\u00a0Dev. Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41420-022-01272-2","article-title":"Primary cilia suppress Ripk3-mediated necroptosis","volume":"8","author":"Kieckh\u00f6fer","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2023.03.011_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/ajprenal.00672.2020","article-title":"IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy","volume":"321","author":"Wang","year":"2021","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib25","doi-asserted-by":"crossref","first-page":"10445","DOI":"10.1002\/jcp.27712","article-title":"Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by down-regulating p150glued","volume":"234","author":"Chen","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib26","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ceb.2012.06.002","article-title":"The extracellular matrix and ciliary signaling","volume":"24","author":"Seeger-Nukpezah","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/ajplung.00410.2015","article-title":"Influence of AQP1 on cell adhesion, migration, and tumor sphere formation in malignant pleural mesothelioma is substratum- and histological-type dependent","volume":"310","author":"Jagirdar","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004593","article-title":"Mechanism of focal adhesion kinase mechanosensing","volume":"11","author":"Zhou","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4161\/org.28910","article-title":"The primary cilium: guardian of organ development and homeostasis","volume":"10","author":"Fry","year":"2014","journal-title":"Organogenesis"},{"key":"10.1016\/j.bbrc.2023.03.011_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155469","article-title":"H\u039cGB1\/sRAGE levels differ significantly between transudates and exudates","volume":"141","author":"Kotsiou","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.bbrc.2023.03.011_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0070-2153(08)00810-7","article-title":"The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair","volume":"85","author":"Christensen","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.101799","article-title":"The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation","volume":"45","author":"Lee","year":"2020","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbrc.2023.03.011_bib33","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ncb2819","article-title":"Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton","volume":"15","author":"Ezan","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.fct.2017.07.055","article-title":"Reactive carbonyl compounds impair wound healing by vimentin collapse and loss of the primary cilium","volume":"108","author":"Rodr\u00edguez-Ribera","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/medicina55060267","article-title":"In silico transcriptomic analysis of wound-healing-associated genes in malignant pleural mesothelioma","volume":"55","author":"Rouka","year":"2019","journal-title":"Medicina (Kaunas)."},{"key":"10.1016\/j.bbrc.2023.03.011_bib36","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/1440-1681.13446","article-title":"Cell and extracellular matrix interaction models in benign mesothelial and malignant pleural mesothelioma cells in 2D and 3D in-vitro","volume":"48","author":"Jagirdar","year":"2021","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/jcp.22704","article-title":"Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization","volume":"227","author":"Jones","year":"2012","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib38","article-title":"Changes in global gene expression associated with 3D structure of tumors: an ex\u00a0vivo matrix-free mesothelioma spheroid model","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2023.03.011_bib39","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/cancers11101446","article-title":"In\u00a0vitro characterization of cisplatin and pemetrexed effects in malignant pleural mesothelioma 3D culture phenotypes","volume":"11","author":"Papazoglou","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2023.03.011_bib40","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ceb.2003.10.016","article-title":"Tissue architecture: the ultimate regulator of breast epithelial function","volume":"15","author":"Bissell","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib41","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.cellbio.22.010305.104315","article-title":"Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer","volume":"22","author":"Nelson","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib42","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/(SICI)1097-0339(199710)17:4<272::AID-DC7>3.0.CO;2-E","article-title":"Confocal laser scanning microscopy and three-dimensional reconstruction of cell clusters in serous fluids","volume":"17","author":"Michael","year":"1997","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib43","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.21873\/anticanres.13530","article-title":"2-Deoxy-glucose enhances the effect of cisplatin and pemetrexed in reducing malignant pleural mesothelioma cell proliferation but not spheroid growth","volume":"39","author":"Gerogianni","year":"2019","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2023.03.011_bib44","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/modpathol.2011.144","article-title":"Epithelial-mesenchymal transition in malignant mesothelioma","volume":"25","author":"Fassina","year":"2012","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib45","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.ajpath.2013.07.029","article-title":"Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-\u03b1 signaling","volume":"183","author":"Qi","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2023.03.011_bib46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/ijms20010150","article-title":"Epithelial to mesenchymal transition in human mesothelial cells exposed to asbestos fibers: role of TGF-\u03b2 as mediator of malignant mesothelioma development or metastasis via EMT event","volume":"20","author":"Turini","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.03.011_bib47","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/thoraxjnl-2020-216602","article-title":"Use of preclinical models for malignant pleural mesothelioma","volume":"76","author":"Shamseddin","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.bbrc.2023.03.011_bib48","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.3390\/cancers13153701","article-title":"Cancer organoids in basic science and translational medicine","volume":"13","author":"Memeo","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2023.03.011_bib49","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.3390\/cancers14153758","article-title":"Organoids as a model for precision medicine in malignant pleural mesothelioma: where are we today?","volume":"14","author":"Gao","year":"2022","journal-title":"Cancers"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23002875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23002875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:28:23Z","timestamp":1757766503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23002875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":49,"alternative-id":["S0006291X23002875"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.03.011","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of pharmacological primary cilium disturbance in the context of in\u00a0vitro 2D and 3D malignant pleura mesothelioma","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}