{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:02:33Z","timestamp":1790650953707,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20200265"],"award-info":[{"award-number":["BK20200265"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF22H030017"],"award-info":[{"award-number":["LGF22H030017"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bbrc.2023.05.027","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T22:50:54Z","timestamp":1684191054000},"page":"120-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["CerS5 deficiency promotes liver fibrosis development in non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"667","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-2780","authenticated-orcid":false,"given":"Jin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjie","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2023.05.027_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"16","key":"10.1016\/j.bbrc.2023.05.027_bib2","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.3748\/wjg.v22.i16.4079","article-title":"Nonalcoholic fatty liver disease as a multi-systemic disease","volume":"22","author":"Fotbolcu","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"21","key":"10.1016\/j.bbrc.2023.05.027_bib3","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1503519","article-title":"Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis","volume":"377","author":"Diehl","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bbrc.2023.05.027_bib4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","article-title":"Current and future pharmacological therapies for NAFLD\/NASH","volume":"53","author":"Sumida","year":"2018","journal-title":"J.\u00a0Gastroenterol."},{"issue":"2","key":"10.1016\/j.bbrc.2023.05.027_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J.\u00a0Hepatol."},{"issue":"6451","key":"10.1016\/j.bbrc.2023.05.027_bib6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.aav3722","article-title":"Targeting a ceramide double bond improves insulin resistance and hepatic steatosis","volume":"365","author":"Chaurasia","year":"2019","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bbrc.2023.05.027_bib7","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jhep.2014.06.009","article-title":"ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis","volume":"61","author":"Fucho","year":"2014","journal-title":"J.\u00a0Hepatol."},{"issue":"38","key":"10.1016\/j.bbrc.2023.05.027_bib8","doi-asserted-by":"crossref","first-page":"23282","DOI":"10.1074\/jbc.M115.677542","article-title":"Sphingosine kinase 1 protects hepatocytes from lipotoxicity via down-regulation of IRE1\u03b1 protein expression","volume":"290","author":"Qi","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2023.05.027_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2021.09.060","article-title":"The alleviating effect of sphingosine kinases 2 inhibitor K145 on nonalcoholic fatty liver","volume":"580","author":"Shi","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbrc.2023.05.027_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/iub.319","article-title":"Mammalian ceramide synthases","volume":"62","author":"Levy","year":"2010","journal-title":"IUBMB Life"},{"issue":"6","key":"10.1016\/j.bbrc.2023.05.027_bib11","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.cell.2019.05.008","article-title":"CerS6-Derived sphingolipids interact with Mff and promote mitochondrial fragmentation in obesity","volume":"177","author":"Hammerschmidt","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2023.05.027_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175536","article-title":"Evaluating the effect of basic fibroblast growth factor on the progression of NASH disease by inhibiting ceramide synthesis and ER stress-related pathways","volume":"942","author":"Rahimi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"13","key":"10.1016\/j.bbrc.2023.05.027_bib13","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1074\/jbc.M115.691212","article-title":"Ceramide synthase 5 is essential to maintain C16:0-ceramide pools and contributes to the development of diet-induced obesity","volume":"291","author":"Gosejacob","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbrc.2023.05.027_bib14","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/1566524016666160607090012","article-title":"LASS5 interacts with SDHB and synergistically represses p53 and p21 activity","volume":"16","author":"Jiang","year":"2016","journal-title":"Curr. Mol. Med."},{"issue":"9","key":"10.1016\/j.bbrc.2023.05.027_bib15","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.7150\/thno.49054","article-title":"SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-\u03baB signaling","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bbrc.2023.05.027_bib16","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1038\/s41467-022-32169-4","article-title":"Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a","volume":"13","author":"Xu","year":"2022","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbrc.2023.05.027_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J.\u00a0Hepatol."},{"issue":"1","key":"10.1016\/j.bbrc.2023.05.027_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12915-017-0462-7","article-title":"Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice","volume":"15","author":"Zheng","year":"2017","journal-title":"BMC Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2023.05.027_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metabol."},{"issue":"2","key":"10.1016\/j.bbrc.2023.05.027_bib20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.gastro.2018.06.031","article-title":"Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis","volume":"155","author":"Musso","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2023.05.027_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103290","article-title":"Conjugated secondary 12\u03b1-hydroxylated bile acids promote liver fibrogenesis","volume":"66","author":"Xie","year":"2021","journal-title":"EBioMedicine"},{"issue":"30","key":"10.1016\/j.bbrc.2023.05.027_bib22","doi-asserted-by":"crossref","first-page":"27879","DOI":"10.1074\/jbc.M503002200","article-title":"Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha","volume":"280","author":"Osawa","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbrc.2023.05.027_bib23","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1074\/jbc.M008732200","article-title":"Natural ceramide reverses Fas resistance of acid sphingomyelinase(-\/-) hepatocytes","volume":"276","author":"Paris","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbrc.2023.05.027_bib24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13238-020-00804-9","article-title":"Targeting the alternative bile acid synthetic pathway for metabolic diseases","volume":"12","author":"Jia","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.bbrc.2023.05.027_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/164_2019_241","article-title":"UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications","volume":"256","author":"Cabrera","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbrc.2023.05.027_bib26","first-page":"1209","article-title":"Effect of ursodeoxycholic acid on TGF beta1\/Smad signaling pathway in rat hepatic stellate cells","volume":"122","author":"Liang","year":"2009","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbrc.2023.05.027_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117175","article-title":"Ursodeoxycholic acid alleviates experimental liver fibrosis involving inhibition of autophagy","volume":"242","author":"Ye","year":"2020","journal-title":"Life Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23005831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23005831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:46:39Z","timestamp":1762094799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23005831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":27,"alternative-id":["S0006291X23005831"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.027","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CerS5 deficiency promotes liver fibrosis development in non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}