{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:16:03Z","timestamp":1784664963491,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2021JJ70059"],"award-info":[{"award-number":["2021JJ70059"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2022JJ70047"],"award-info":[{"award-number":["2022JJ70047"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bbrc.2023.05.117","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T19:03:07Z","timestamp":1685818987000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Hesperidin inhibits methylation and autophagy in LPS and high glucose-induced human villous trophoblasts"],"prefix":"10.1016","volume":"671","author":[{"given":"Qiuling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2023.05.117_bib1","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1097\/CM9.0000000000002160","article-title":"Molecular biomarkers for gestational diabetes mellitus and postpartum diabetes","volume":"135","author":"Lu","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbrc.2023.05.117_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102926","article-title":"Molecular biomarkers for gestational diabetes mellitus","volume":"19","author":"Dias","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.05.117_bib3","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1007\/s43032-020-00456-4","article-title":"Maternal DNA methylation during pregnancy: a review","volume":"28","author":"Das","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bbrc.2023.05.117_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2337\/dc19-0524","article-title":"Maternal gestational diabetes mellitus and newborn DNA methylation: findings from the pregnancy and childhood epigenetics consortium","volume":"43","author":"Howe","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2023.05.117_bib5","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ije\/dyv048","article-title":"DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring","volume":"44","author":"K\u00fcpers","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbrc.2023.05.117_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/1471-0528.13700","article-title":"Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescent offspring: a prospective cohort study","volume":"123","author":"Gaillard","year":"2016","journal-title":"Bjog"},{"key":"10.1016\/j.bbrc.2023.05.117_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10408363.2017.1422109","article-title":"Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring","volume":"55","author":"Agarwal","year":"2018","journal-title":"Crit. Rev. Clin. Lab Sci."},{"key":"10.1016\/j.bbrc.2023.05.117_bib8","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s00125-019-4951-9","article-title":"Intrauterine programming of obesity and type 2 diabetes","volume":"62","author":"Fernandez-Twinn","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2023.05.117_bib9","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.1111\/jcmm.15984","article-title":"Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus","volume":"24","author":"Zhu","year":"2020","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2023.05.117_bib10","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","article-title":"m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7","volume":"16","author":"Wang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2023.05.117_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/annrheumdis-2021-221091","article-title":"METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression","volume":"81","author":"Chen","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2023.05.117_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00894-022-05407-1","article-title":"Amentoflavone and methyl hesperidin, novel lead molecules targeting epitranscriptomic modulator in acute myeloid leukemia: in silico drug screening and molecular dynamics simulation approach","volume":"29","author":"Manna","year":"2022","journal-title":"J.\u00a0Mol. Model."},{"key":"10.1016\/j.bbrc.2023.05.117_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13098-021-00664-1","article-title":"Hesperidin alleviates insulin resistance by improving HG-induced oxidative stress and mitochondrial dysfunction by restoring miR-149","volume":"13","author":"Tian","year":"2021","journal-title":"Diabetol. Metab. Syndrome"},{"key":"10.1016\/j.bbrc.2023.05.117_bib14","article-title":"Correlation analysis of umbilical cord blood metabolic phenotype and inflammation in patients with gestational diabetes mellitus complicated with overweight and obesity","author":"Chen","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.bbrc.2023.05.117_bib15","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1210\/clinem\/dgaa466","article-title":"Exposure to gestational diabetes enriches immune-related pathways in the transcriptome and methylome of human amniocytes","volume":"105","author":"Pinney","year":"2020","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2023.05.117_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2014.06.037","article-title":"Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation","volume":"211","author":"Lesseur","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2023.05.117_bib17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/HYPERTENSIONAHA.119.12634","article-title":"Hypertensive disorders of pregnancy and DNA methylation in newborns","volume":"74","author":"Kazmi","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2023.05.117_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.705263","article-title":"Novel role of gestational hydralazine in limiting maternal and dietary obesity-related chronic kidney disease","volume":"9","author":"Larkin","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2023.05.117_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248854","article-title":"Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet","volume":"16","author":"Larkin","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2023.05.117_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jri.2018.05.005","article-title":"Soluble inflammatory mediators induce transcriptional re-organization that is independent of dna methylation changes in cultured human chorionic villous trophoblasts","volume":"128","author":"Jiang","year":"2018","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.bbrc.2023.05.117_bib21","article-title":"Prenatal exposure to lipopolysaccharide alters renal DNA methyltransferase expression in rat offspring","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2023.05.117_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.placenta.2021.12.022","article-title":"High glucose increases IGF-2\/H19 expression by changing DNA methylation in HTR8\/SVneo trophoblast cells","volume":"118","author":"Zhang","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.bbrc.2023.05.117_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104629","article-title":"Flavonoids and type 2 diabetes: evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy","volume":"152","author":"Hussain","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2023.05.117_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/nu12102907","article-title":"Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: a systematic review of in\u00a0vitro and in\u00a0vivo studies","volume":"12","author":"Gandhi","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2023.05.117_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5484138","article-title":"Beneficial effects of citrus flavonoids on cardiovascular and metabolic health","author":"Mahmoud","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2023.05.117_bib26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.foodchem.2018.08.036","article-title":"Antioxidative effects of flavonoids and their metabolites against hypoxia\/reoxygenation-induced oxidative stress in a human first trimester trophoblast cell line","volume":"272","author":"Ebegboni","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2023.05.117_bib27","first-page":"241","article-title":"The relationship of flavonoid intake during pregnancy with excess body weight and gestational diabetes mellitus","volume":"63","author":"Balbi","year":"2019","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.bbrc.2023.05.117_bib28","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3945\/ajcn.116.136960","article-title":"Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals","volume":"104","author":"Salden","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2023.05.117_bib29","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ptr.6046","article-title":"Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial","volume":"32","author":"Homayouni","year":"2018","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2023.05.117_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105824","article-title":"Defective insulin receptor signaling in patients with gestational diabetes is related to dysregulated miR-140 which can be improved by naringenin","volume":"128","author":"Zhao","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2023.05.117_bib31","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/mc.22621","article-title":"Demethylating and anti-hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices","volume":"56","author":"Fern\u00e1ndez-Bedmar","year":"2017","journal-title":"Mol. Carcinog."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23007064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23007064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:48:19Z","timestamp":1762094899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23007064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":31,"alternative-id":["S0006291X23007064"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.117","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hesperidin inhibits methylation and autophagy in LPS and high glucose-induced human villous trophoblasts","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.05.117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}