{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:53:05Z","timestamp":1779897185168,"version":"3.53.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bbrc.2023.09.043","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T10:53:51Z","timestamp":1695466431000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Impact of antipsychotics and antidepressants drugs on long QT syndrome induction related to hERG channel dysfunction: A systematic review"],"prefix":"10.1016","volume":"681","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-0847","authenticated-orcid":false,"given":"Marzieh","family":"Nemati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Nemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2023.09.043_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.bjp.0706892","article-title":"Drug-induced long QT syndrome: hERG K + channel block and disruption of protein trafficking by fluoxetine and norfluoxetine","volume":"149","author":"Rajamani","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.bbrc.2023.09.043_bib2","first-page":"1895","article-title":"Cardiac safety evaluation of berberine combining with berberine-derived medicine","volume":"54","author":"Zhang","year":"2019","journal-title":"Acta Pharm. Sin."},{"issue":"3","key":"10.1016\/j.bbrc.2023.09.043_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/1091581809337261","article-title":"Cellular mechanism of the QT prolongation induced by sulpiride","volume":"28","author":"Lee","year":"2009","journal-title":"Int. J. Toxicol."},{"issue":"4","key":"10.1016\/j.bbrc.2023.09.043_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.bjp.0706744","article-title":"Blockade of HERG human K + channels and I (Kr) of Guinea-pig cardiomyocytes by the antipsychotic drug clozapine","volume":"148","author":"Lee","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2023.09.043_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/bdrb.21003","article-title":"Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro","volume":"95","author":"Ababneh","year":"2012","journal-title":"Birth Defects Res. Part B Dev. Reproductive Toxicol."},{"issue":"2","key":"10.1016\/j.bbrc.2023.09.043_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00210-004-0952-3","article-title":"Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone","volume":"370","author":"Zitron","year":"2004","journal-title":"N. Schmied. Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2023.09.043_bib7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjp.0705283","article-title":"The antipsychotic drug chlorpromazine inhibits HERG potassium channels","volume":"139","author":"Thomas","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2023.09.043_bib8","first-page":"1393","article-title":"hERG K+ channels: structure, function, and clinical significance","volume":"92","author":"Vandenberg","year":"2012","journal-title":"Asia Pac. J. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2023.09.043_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4196\/kjpp.2017.21.1.75","article-title":"Acepromazine inhibits hERG potassium ion channels expressed in human embryonic kidney 293 cells","volume":"21","author":"Joo","year":"2017","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.bbrc.2023.09.043_bib10","first-page":"2020","article-title":"LongevityThioridazine induces cardiotoxicity via reactive oxygen species-mediated hERG channel deficiency and L-type calcium channel activation","author":"Liu","year":"2020","journal-title":"Oxidative Medicine and Cellular"},{"issue":"6","key":"10.1016\/j.bbrc.2023.09.043_bib12","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00005344-200306000-00016","article-title":"Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current","volume":"41","author":"Drolet","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2023.09.043_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.vascn.2005.04.001","article-title":"Additive effects of ziprasidone and D,L-sotalol on the action potential in rabbit Purkinje fibres and on the hERG potassium current","volume":"52","author":"Ducroq","year":"2005","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"3","key":"10.1016\/j.bbrc.2023.09.043_bib15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1081\/DCT-200064482","article-title":"The phenothiazine drugs inhibit hERG potassium channels","volume":"28","author":"Kim","year":"2005","journal-title":"Drug Chem. Toxicol."},{"issue":"1\u20133","key":"10.1016\/j.bbrc.2023.09.043_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2006.06.009","article-title":"Blockade of HERG human K+ channel and IKr of Guinea pig cardiomyocytes by prochlorperazine","volume":"544","author":"Kim","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2023.09.043_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbrc.2006.10.039","article-title":"hERG K+ channel blockade by the antipsychotic drug thioridazine: an obligatory role for the S6 helix residue F656","volume":"351","author":"Milnes","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bbrc.2023.09.043_bib17","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-3565(24)37654-2","article-title":"The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG","volume":"286","author":"Rampe","year":"1998","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"1","key":"10.1016\/j.bbrc.2023.09.043_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.yjmcc.2003.10.017","article-title":"Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel","volume":"36","author":"Su","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.bbrc.2023.09.043_bib19","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/sj.bjp.0700989","article-title":"The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes","volume":"120","author":"Suessbrich","year":"1997","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2023.09.043_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.phrs.2012.03.008","article-title":"Iloperidone (Fanapt \u00ae), a novel atypical antipsychotic, is a potent HERG blocker and delays cardiac ventricular repolarization at clinically relevant concentration","volume":"66","author":"Vigneault","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"39","key":"10.1016\/j.bbrc.2023.09.043_bib23","doi-asserted-by":"crossref","first-page":"34413","DOI":"10.1074\/jbc.M111.254367","article-title":"Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG","volume":"286","author":"Dennis","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5\u20136","key":"10.1016\/j.bbrc.2023.09.043_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.lfs.2007.12.004","article-title":"Protriptyline block of the human ether-\u00e0-go-go-related gene (HERG) K+ channel","volume":"82","author":"Jo","year":"2008","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.bbrc.2023.09.043_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s00210-006-0068-z","article-title":"Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels","volume":"373","author":"Kiesecker","year":"2006","journal-title":"N. Schmied. Arch. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbrc.2023.09.043_bib14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0960327115595683","article-title":"Cellular mechanisms for trazodone-induced cardiotoxicity","volume":"35","author":"Lee","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"issue":"5","key":"10.1016\/j.bbrc.2023.09.043_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4196\/kjpp.2012.16.5.327","article-title":"Wide spectrum of inhibitory effects of sertraline on cardiac ion channels","volume":"16","author":"Lee","year":"2012","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"issue":"5","key":"10.1016\/j.bbrc.2023.09.043_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/sj.bjp.0706890","article-title":"Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology","volume":"149","author":"Hancox","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.bbrc.2023.09.043_bib11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11010-008-9914-2","article-title":"Effect of sibutramine HCl on cardiac hERG K+ channel","volume":"320","author":"Kim","year":"2009","journal-title":"Mol. Cell. Biochem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23010793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23010793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:33:31Z","timestamp":1757766811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23010793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":26,"alternative-id":["S0006291X23010793"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.09.043","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of antipsychotics and antidepressants drugs on long QT syndrome induction related to hERG channel dysfunction: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.09.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}