{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:17:15Z","timestamp":1773976635347,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03578"],"award-info":[{"award-number":["20H03578"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024233","name":"Natural Science Center for Basic Research and Development, Hiroshima University","doi-asserted-by":"publisher","award":["NBARD-00014"],"award-info":[{"award-number":["NBARD-00014"]}],"id":[{"id":"10.13039\/501100024233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019471","name":"Mitsubishi Chemical Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bbrc.2023.10.038","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:51:54Z","timestamp":1696917114000},"page":"149106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Apolipoprotein E genotype-dependent accumulation of amyloid \u03b2 in APP-knock-in mouse model of Alzheimer's disease"],"prefix":"10.1016","volume":"683","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-5553","authenticated-orcid":false,"given":"Yoshiko","family":"Takebayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-0646","authenticated-orcid":false,"given":"Hidetada","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Yazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-5538","authenticated-orcid":false,"given":"Masahiro","family":"Nakamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-5979","authenticated-orcid":false,"given":"Takashi","family":"Kurashige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Morino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-0842","authenticated-orcid":false,"given":"Tetsuya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sotomaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-8717","authenticated-orcid":false,"given":"Hirofumi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2023.10.038_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41582-019-0228-7","article-title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","volume":"15","author":"Yamazaki","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbrc.2023.10.038_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120861","article-title":"Alzheimer's disease failed clinical trials","volume":"306","author":"Asher","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2023.10.038_bib3","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2023.10.038_bib4","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2023.10.038_bib5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2023.10.038_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/hmg\/9.3.353","article-title":"Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice","volume":"9","author":"Hamanaka","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2023.10.038_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/jnen\/62.3.280","article-title":"Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice","volume":"62","author":"Mori","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbrc.2023.10.038_bib8","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1177\/0271678X16668889","article-title":"Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - hyperphosphorylation and cleavage of 4- and 3-repeat tau","volume":"37","author":"Fujii","year":"2017","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.bbrc.2023.10.038_bib9","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1523\/JNEUROSCI.4792-03.2004","article-title":"Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain","volume":"24","author":"Iwata","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2023.10.038_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100654","article-title":"Protocols for assessing neurodegenerative phenotypes in Alzheimer's mouse models","volume":"2","author":"Kang","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.bbrc.2023.10.038_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neurobiolaging.2004.09.003","article-title":"Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease","volume":"26","author":"Poirier","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2023.10.038_bib12","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1523\/JNEUROSCI.0887-09.2009","article-title":"Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice","volume":"29","author":"Bales","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2023.10.038_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jneumeth.2010.12.025","article-title":"Amyloid-\u03b242 alters apolipoprotein E solubility in brains of mice with five familial AD mutations","volume":"196","author":"Youmans","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbrc.2023.10.038_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1460-9568.2005.04551.x","article-title":"Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1","volume":"23","author":"Ohno","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2023.10.038_bib15","doi-asserted-by":"crossref","first-page":"15938","DOI":"10.1073\/pnas.0908176106","article-title":"Reelin signaling antagonizes beta-amyloid at the synapse","volume":"106","author":"Durakoglugil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2023.10.038_bib16","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.neuron.2020.11.019","article-title":"Vascular ApoE4 impairs behavior by modulating gliovascular function","volume":"109","author":"Yamazaki","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2023.10.038_bib17","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1534\/genetics.105.051912","article-title":"Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL\/6 and C3H mice carrying the mutant apolipoprotein E gene","volume":"172","author":"Su","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2023.10.038_bib18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.neurobiolaging.2007.11.014","article-title":"APOE genotype-specific differences in the innate immune response","volume":"30","author":"Vitek","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2023.10.038_bib19","doi-asserted-by":"crossref","first-page":"41774","DOI":"10.1074\/jbc.M112.407957","article-title":"APOE4-specific changes in A\u03b2 accumulation in a new transgenic mouse model of Alzheimer disease","volume":"287","author":"Youmans","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2023.10.038_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neurobiolaging.2015.10.010","article-title":"The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice","volume":"37","author":"Cacciottolo","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2023.10.038_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1742-2094-11-111","article-title":"Human APOE4 increases microglia reactivity at A\u03b2 plaques in a mouse model of A\u03b2 deposition","volume":"11","author":"Rodriguez","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2023.10.038_bib22","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2023.10.038_bib23","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1056\/NEJM199511093331902","article-title":"Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein","volume":"333","author":"Polvikoski","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2023.10.038_bib24","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1172\/JCI124853","article-title":"APOE4-mediated amyloid-\u03b2 pathology depends on its neuronal receptor LRP1","volume":"129","author":"Tachibana","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2023.10.038_bib25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/NEN.0b013e3182933788","article-title":"Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease","volume":"72","author":"Serrano-Pozo","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23011907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23011907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:48:32Z","timestamp":1762094912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23011907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":25,"alternative-id":["S0006291X23011907"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.10.038","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apolipoprotein E genotype-dependent accumulation of amyloid \u03b2 in APP-knock-in mouse model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.10.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149106"}}