{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:55:17Z","timestamp":1762095317904,"version":"build-2065373602"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8187020099","Z2FYFH12"],"award-info":[{"award-number":["8187020099","Z2FYFH12"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bbrc.2023.149391","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:09:01Z","timestamp":1703722141000},"page":"149391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Melatonin inhibits the formation of intraplaque neovessels in ApoE\u2212\/\u2212 mice via PPAR\u03b3- RhoA-ROCK pathway"],"prefix":"10.1016","volume":"696","author":[{"given":"YuFan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-4248","authenticated-orcid":false,"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-9375","authenticated-orcid":false,"given":"YunDai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2021","series-title":"Cardiovascular Diseases Fact Sheet","key":"10.1016\/j.bbrc.2023.149391_bib1"},{"key":"10.1016\/j.bbrc.2023.149391_bib2","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2023.149391_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbrc.2023.149391_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41569-023-00883-1","article-title":"Flow-induced reprogramming of endothelial cells in atherosclerosis","volume":"20","author":"Tamargo","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbrc.2023.149391_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.vph.2018.06.014","article-title":"Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis","volume":"112","author":"Perrotta","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2023.149391_bib6","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/S0021-9258(18)69351-2","article-title":"Isolation of melatonin and 5-Methoxyindole-3-acetic acid from bovine pineal glands","volume":"235","author":"Lerner","year":"1960","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2023.149391_bib7","article-title":"Relationship between melatonin and cardiovascular disease","volume":"13","author":"Ozkalayci","year":"2021","journal-title":"Cureus J. Med. Sci."},{"key":"10.1016\/j.bbrc.2023.149391_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12471","article-title":"Protective role of melatonin in cardiac ischemia-reperfusion injury: from pathogenesis to targeted therapy","volume":"64","author":"Zhou","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10456-019-09689-7","article-title":"Role of melatonin in controlling angiogenesis under physiological and pathological conditions","volume":"23","author":"Ma","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbrc.2023.149391_bib10","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1038\/s41467-021-24736-y","article-title":"S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo\/YAP-dependent diabetes-accelerated atherosclerosis","volume":"12","author":"Chao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2023.149391_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12581","article-title":"Melatonin stabilizes rupture\u2010prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor ROR\u03b1\u2010dependent manner","volume":"67","author":"Ding","year":"2019","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.826811","article-title":"The role of peroxisome proliferator-activated receptor gamma and atherosclerosis: post-translational modification and selective modulators","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2023.149391_bib13","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.3390\/cells9122658","article-title":"The interplay of WNT and PPAR\u03b3 signaling in vascular calcification","author":"Reinhold","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2023.149391_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2337\/diabetes.55.03.06.db05-0832","article-title":"The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of Rosiglitazone treatment","volume":"55","author":"Marfella","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2023.149391_bib15","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.2174\/0929867327666200716113136","article-title":"Role of peroxisome proliferated activated receptor gamma (PPARgamma) in different disease states: recent updates","volume":"28","author":"Mal","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2023.149391_bib16","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1517\/13543784.16.10.1561","article-title":"Peroxisome proliferator-activated receptor-\u03b3 ligands as investigational modulators of angiogenesis","volume":"16","author":"Giaginis","year":"2007","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.bbrc.2023.149391_bib17","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/ijms24032345","article-title":"Pharmacological utility of PPAR modulation for angiogenesis in cardiovascular disease","author":"Wagner","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.149391_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12438","article-title":"Melatonin suppresses platelet activation and function against cardiac ischemia\/reperfusion injury via PPAR\u03b3\/FUNDC1\/mitophagy pathways","volume":"63","author":"Zhou","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105191","article-title":"Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model","volume":"75","author":"Do\u011fanlar","year":"2021","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.bbrc.2023.149391_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.intimp.2015.11.011","article-title":"Protective effects of melatonin on lipopolysaccharide-induced mastitis in mice","volume":"29","author":"Shao","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bbrc.2023.149391_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113852118","article-title":"Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland","volume":"118","author":"Lee","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2023.149391_bib22","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1038\/emboj.2010.197","article-title":"The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites","volume":"29","author":"Waku","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2023.149391_bib23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/01.RES.0000201960.04223.3c","article-title":"Rho kinases in cardiovascular physiology and pathophysiology","volume":"98","author":"Loirand","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib24","doi-asserted-by":"crossref","first-page":"C661","DOI":"10.1152\/ajpcell.00459.2005","article-title":"Physiological role of ROCKs in the cardiovascular system","volume":"290","author":"Noma","year":"2006","journal-title":"Am. J. Physiol.-Cell. Ph"},{"key":"10.1016\/j.bbrc.2023.149391_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2022.08.012","article-title":"Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: implications for vascular function","volume":"358","author":"Sawma","year":"2022","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbrc.2023.149391_bib26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3390\/ijms22010216","article-title":"Role of macrophages and RhoA pathway in atherosclerosis","volume":"22","author":"Kloc","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.149391_bib27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the endothelial barrier: identifying and reconciling controversies","volume":"27","author":"Claesson-Welsh","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2023.149391_bib28","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.7150\/thno.30305","article-title":"Rho-associated coiled-coil kinase (ROCK) in molecular regulation of angiogenesis","volume":"8","author":"Liu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2023.149391_bib29","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1161\/HYPERTENSIONAHA.120.16518","article-title":"EP3 (E-Prostanoid 3) receptor mediates impaired vasodilation in a mouse model of salt-sensitive hypertension","volume":"77","author":"Wu","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2023.149391_bib30","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3390\/biom11091301","article-title":"Repurposing small molecules to target PPAR-gamma as new therapies for peripheral nerve injuries","volume":"11","author":"Rayner","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbrc.2023.149391_bib31","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3390\/ijms22042004","article-title":"Deciphering the role of wnt and Rho signaling pathway in iPSC-derived ARVC cardiomyocytes by in silico mathematical modeling","volume":"22","author":"Parrotta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.149391_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/HYPERTENSIONAHA.117.10799","article-title":"Endothelial PPAR\u03b3 (peroxisome proliferator\u2013activated receptor-\u03b3) is essential for preventing endothelial dysfunction with aging","volume":"72","author":"De Silva","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2023.149391_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12778","article-title":"Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring","volume":"72","author":"Jia","year":"2022","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jpi.12270","article-title":"Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression","volume":"60","author":"Borin","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12660","article-title":"Melatonin attenuates choroidal neovascularization by regulating macrophage\/microglia polarization via inhibition of RhoA\/ROCK signaling pathway","volume":"69","author":"Xu","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib36","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1021\/acs.jafc.8b06217","article-title":"Melatonin inhibits in vitro smooth muscle cell inflammation and proliferation and atherosclerosis in apolipoprotein E-deficient mice","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2023.149391_bib37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fphar.2018.00464","article-title":"Ginsenoside Rg3 mitigates atherosclerosis progression in diabetic apoE\u2013\/\u2013 mice by skewing macrophages to the M2 phenotype","volume":"9","author":"Guo","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2023.149391_bib38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/CIRCRESAHA.113.301562","article-title":"A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic\/therapeutic discoveries using gene and MicroRNA expression profiling","volume":"113","author":"Chen","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117404","article-title":"Design and discovery of new selective and potent VEGF receptor 2 tyrosine kinase inhibitors","volume":"91","author":"Hou","year":"2023","journal-title":"Bioorgan. Med. Chem."},{"key":"10.1016\/j.bbrc.2023.149391_bib40","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.2147\/JIR.S329020","article-title":"Melatonin alleviates age-associated endothelial injury of atherosclerosis via regulating telomere function","volume":"14","author":"Xie","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib41","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphar.2020.00500","article-title":"Ginsenoside Rg3 alleviates ox-LDL induced endothelial dysfunction and prevents atherosclerosis in ApoE(-\/-) mice by regulating PPARgamma\/FAK signaling pathway","volume":"11","author":"Geng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2023.149391_bib42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ddr.21773","article-title":"Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA\/ROCK signaling pathway","volume":"82","author":"Chen","year":"2021","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib43","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1161\/CIRCULATIONAHA.109.887497","article-title":"Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome","volume":"121","author":"Hellings","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2023.149391_bib44","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/CIRCULATIONAHA.105.535294","article-title":"Role of angiogenesis in cardiovascular disease","volume":"112","author":"Khurana","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2023.149391_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12950-021-00269-5","article-title":"Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease","volume":"18","author":"Rahbarghazi","year":"2021","journal-title":"J. Inflamm."},{"key":"10.1016\/j.bbrc.2023.149391_bib46","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.3390\/cancers13133263","article-title":"Melatonin as an adjuvant to antiangiogenic cancer treatments","volume":"13","author":"Gonz\u00e1lez","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2023.149391_bib47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.taap.2017.09.022","article-title":"Melatonin as an angiogenesis inhibitor to combat cancer: mechanistic evidence","volume":"335","author":"Goradel","year":"2017","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.bbrc.2023.149391_bib48","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2174\/1871520614666140812110246","article-title":"Molecular markers of angiogenesis and metastasis in lines of oral carcinoma after treatment with melatonin","volume":"14","author":"Goncalves","year":"2014","journal-title":"Anti-Cancer Agent Me"},{"key":"10.1016\/j.bbrc.2023.149391_bib49","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.3892\/mmr.2017.7836","article-title":"Melatonin inhibits colon cancer RKO cell migration by downregulating Rhoassociated protein kinase expression via the p38\/MAPK signaling pathway","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2023.149391_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.theriogenology.2022.02.029","article-title":"Melatonin supplementation preserves testicular function by attenuating lactate production and oxidative stress in high fat diet-induced obese rat model","volume":"187","author":"Saidi","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.bbrc.2023.149391_bib51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1631\/jzus.B2200136","article-title":"Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus","volume":"24","author":"Wei","year":"2023","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.bbrc.2023.149391_bib52","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1089\/ars.2008.2280","article-title":"PPARs and the cardiovascular system","volume":"11","author":"Hamblin","year":"2009","journal-title":"Antioxid Redox Sign"},{"key":"10.1016\/j.bbrc.2023.149391_bib53","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1517\/14728222.2010.512917","article-title":"PPARs as therapeutic targets in cardiovascular disease","volume":"14","author":"van Bilsen","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbrc.2023.149391_bib54","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.3390\/ijms21165723","article-title":"PPARs and angiogenesis\u2014implications in pathology","volume":"21","author":"Wagner","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2023.149391_bib55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/B:AGEN.0000021377.13669.c0","article-title":"Peroxisome proliferator activated receptor-gamma (PPAR-gamma) ligands and angiogenesis","volume":"6","author":"Margeli","year":"2003","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbrc.2023.149391_bib56","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCRESAHA.110.221317","article-title":"Short communication: PPAR\u03b3 mediates a direct antiangiogenic effect of \u03c93-PUFAs in proliferative retinopathy","volume":"107","author":"Stahl","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2023.149391_bib57","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3390\/biom11091301","article-title":"Repurposing small molecules to target PPAR-\u03b3 as new therapies for peripheral nerve injuries","volume":"11","author":"Rayner","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbrc.2023.149391_bib58","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.21037\/atm-20-1974","article-title":"Carotid intraplaque haemorrhage: pathogenesis, histological classification, imaging methods and clinical value","volume":"8","author":"Mura","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bbrc.2023.149391_bib59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10557-020-07052-3","article-title":"Clinical application of melatonin in the treatment of cardiovascular diseases: current evidence and new insights into the cardioprotective and cardiotherapeutic properties","volume":"36","author":"Pourhanifeh","year":"2022","journal-title":"Cardiovasc. Drug Ther."},{"key":"10.1016\/j.bbrc.2023.149391_bib60","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41569-021-00569-6","article-title":"PPAR control of metabolism and cardiovascular functions","volume":"18","author":"Montaigne","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbrc.2023.149391_bib61","article-title":"Enhanced efficiency of melatonin by stepwise-targeting strategy for acute lung injury","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Bioeng. Biotech."},{"key":"10.1016\/j.bbrc.2023.149391_bib62","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.7150\/thno.59759","article-title":"Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque","volume":"11","author":"Song","year":"2021","journal-title":"THERANOSTICS"},{"key":"10.1016\/j.bbrc.2023.149391_bib63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1124\/jpet.122.001384","article-title":"Endothelial-specific targeting of RhoA signaling via CD31 antibody-conjugated nanoparticles","volume":"385","author":"Behnaz","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23014857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23014857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:50:29Z","timestamp":1762095029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23014857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":63,"alternative-id":["S0006291X23014857"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.149391","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin inhibits the formation of intraplaque neovessels in ApoE\u2212\/\u2212 mice via PPAR\u03b3- RhoA-ROCK pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.149391","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149391"}}